The Goldstein Lab@UM
@LabGoldstein
Our lab investigates novel pathways by which aging enhances inflammation and disease
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How does #aging increase mortality to #influenza? Our study by brilliant grad student @merpJC at @LabGoldstein @UMMicroImmuno @UMIntMed @umichCVC @UMichResearch @UMichCardiology provides an answer: doi.org/10.1038/s41467… PDF nature.com/articles/s4146….
Check out our paper @JCI_insight on nanotherapeutics to improve outcomes during #influenza with aging @umichmedicine @UMMicroImmuno @umichCVC @UMIntMed @LabGoldstein @UMichCardiology @UMichResearch @UMichImmunology insight.jci.org/articles/view/…
So proud of you! Fantastic work at @LabGoldstein @umichmedicine @umichCVC wishing you all the best!
Check out the preprint from Grad Student Judy Chen working in @LabGoldstein showing PGE2 regulates flu susceptibility in aged mice biorxiv.org/content/10.110…
Want to know a mechanism by which #aging impairs #influenza infection? Check out👇 by super grad student @merpJC @UMichImmunology @umichCVC @UMMicroImmuno @umichmedicine biorxiv.org/content/10.110…
Great job! Judy Chen @merpJC and Billy Kelley of @LabGoldstein @UMichImmunology @UMMicroImmuno - their #COVID19 and #aging review is top 10 read March'21 at The Journal Immunology @ImmunologyAAI mailchi.mp/aai/the-journa…
V honored to be elected to the AAP aap-online.org Thanks to all who supported me. Thanks also to @umichCVC @umichmedicine @UMIntMed for allowing my research to flourish. Thanks to @LabGoldstein for working so hard! Go Blue! @UMich
Looking for post docs esp recent grads @LabGoldstein sites.google.com/umich.edu/gold… @UMMicroImmuno @UmichCVC @UmichImmunology #mitochondrial function in age assoc conditions: #respiratory viral infections + #vascular inflammation careers.umich.edu/job_detail/193…
Happy Holidays + Merry Xmas! #Senolytics - being evaluated in multiple conditions. Would they work in acute respiratory viral infections? Not clear: check our perspective at @ERSpublications @umichCVC @UMIntMed @UMichImmunology erj.ersjournals.com/content/56/6/2…
Jan'21 Issue of @TheJHLT of @ISHLT online now! Great science: #lungtransplantation #MCS #pediatric heart transplantation. Look for tweets from @YasMoayedi + @amansidhuMD Thanks: @MRMehraMD 10 yrs of leadership + ongoing advice jhltonline.org/current
Our @TheJHLT Jan podcast will feature this study: Donor ventilation parameters and lung transplantation. Podcast contributed by Dr. Erika Lease @UW Stay tuned! @YasMoayedi @amansidhuMD @ISHLT @umichCVC jhltonline.org/article/S1053-…
Our Jan'21 podcast @TheJHLT @ISHLT will feature this study: thrombosis events + LVADS. Contributed by @MartyTamMD @tonkhueMdPhd Stay tuned! @YasMoayedi @amansidhuMD @umichCVC jhltonline.org/article/S1053-…
Congrats to Dan Tyrrell @dantyrr well deserved after working so hard to revise paper during the shutdown from #COVID19!
Congrats! @dantyrr @michCVC @umichmedicine @UmichImmunology @UMichCardiology @UMichResearch Just published @JAHA_AHA novel pathway by which aging may predispose the cerebral vasculature to stroke ahajournals.org/doi/suppl/10.1…
Join us tomorrow for our symposium "Mechanisms of declining protective immunity despite heightened chronic inflammation during aging" Chaired by @DrEmilyGoldberg! Speakers Dawn Bowdish, Mladen Jergovic, Elsa Bou Ghanem, and Dan Winer! Links at lamminglab.org/agingscitalks.…
Senescence associates with fibrotic lung diseases. Emerging therapies to reduce senescence may treat chronic lung diseases, but the impact of senescence during acute respiratory viral infections is unclear and requires future investigation. erj.ersjournals.com/content/early/…
Great job Billy!
Please check out our perspective @ERSpublications on senescence and respiratory viral infections, is it good or bad? And impact for #COVID19? Congrats to Billy 1st author! @UMichResearch @UMichImmunology @umichCVC @umichmedicine erj.ersjournals.com/content/early/…
New Review online! Tyrrell and Goldstein discuss vascular intrinsic and extrinsic mechanisms by which #aging promotes #atherosclerosis rdcu.be/b64Qy @Gracedan10_99 @dantyrr @LabGoldstein @umichmedicine @umichCVC
Dysregulation of self-renewal contributes to alterations in alveolar macrophages. Penke et al identify PGE2 as a suppressor of AM proliferation whose divergent bioavailability in aged & cigarette smoke-exposed mice could explain opposite effects on AM #'s. bit.ly/3bbLrDA
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