The Janda Lab
@LabJanda
Student run Twitter account for the lab of Prof. Kim Janda @ScrippsResearch. Follow for updates on current research in our group!
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Earlier this year we published our approach using a catalytic antibody to not only sequester carfentanil, but inactivate it. Ming will be presenting this paper along with other great work he has done at his defense in September! pubs.acs.org/doi/10.1021/ac…
#Hybridoma screening, #pharmacokinetics and #pain tests enabled Kim Janda’s team at @scrippsresearch develop a monoclonal #antibody against #heroin in mice. genengnews.com/topics/drug-di…
Our latest work showcasing a promising opioid immunopharmacotherapy and how it can help shift trends in vaccine development.
NEW #ASAP Therapeutic monoclonal antibody for heroin abuse/overdose by @LabJanda shows vaccines have been mistargeting heroin’s metabolites for decades and should refocus efforts on heroin itself. Read here: go.acs.org/2tG
Collaboration with Prof. Andrianov at the University of Maryland showed PCEP to be a promising adjuvant for anti-drug vaccines. When hapten design is already optimized, finding new adjuvants for intranasal immunization is the way to go. Check it out here: pubs.acs.org/doi/10.1021/ac…
pubs.acs.org
Polyphosphazene: A New Adjuvant Platform for Cocaine Vaccine Development
Cocaine is a highly addictive drug that has seen a steady uptrend causing severe health problems worldwide. Currently, there are no approved therapeutics for treating cocaine use disorder; hence,...
Check out our latest paper: Identification of Slow-Binding Inhibitors of the Botulinum Neurotoxin Protease pubs.acs.org/doi/10.1021/ac… Congrats Ealin!
Our most recent publication in JMC: A Vaccine against Benzimidazole-Derived New Psychoactive Substances That Are More Potent Than Fentanyl pubs.acs.org/doi/10.1021/ac… Congrats Jinny and Hyeri!
pubs.acs.org
A Vaccine against Benzimidazole-Derived New Psychoactive Substances That Are More Potent Than...
New psychoactive substance (NPS) opioids have proliferated within the international drug market. While synthetic opioids are traditionally composed of fentanyl analogues, benzimidazole-derived...
During National Immunization Awareness Month (August 2021), we congratulate Dr. Kim D Janda of Scripps Clinic and Research Institute -- Recognized as an Expertscape Expert in Synthetic Vaccines. expertscape.com/ex/vaccines%2C…
Our lab recently published a potential therapeutic for the synthetic cannabinoid PB-22. Congrats Ming! pubs.acs.org/doi/10.1021/ac…
Salicylanilides as a promising therapeutic for COVID-19? Check out our latest paper to read more about it! pubs.acs.org/doi/10.1021/ac…
Check out a synthetic fluorescent MYC probe we found and how we developed a high-throughput screening assay that found a promising lead compound. sciencedirect.com/science/articl…
A new paper from our lab is out on Chemrxiv that used structure-based drug design as a way to develop inhibitors of botulinum neurotoxin A protease. Congrats @LewisTu52514415 and @alexanderln91! doi.org/10.26434/chemr…
Check out our latest work on an improved dual hapten vaccine for fentanyl-contaminated heroin! sciencedirect.com/science/articl…
Congrats to Lisa on the paper published today on two synthetic opioid vaccines! It not only elicits high-affinity antibodies against carfentanil and fentanyl, but also offers protection against opioid-induced respiratory depression. pubs.acs.org/doi/10.1021/ac…
We're excited to share our latest work on the first broadly neutralizing vaccine for synthetic cannabinoids in JACS Au! pubs.acs.org/doi/10.1021/ja…
Happy to share our latest work on bifunctional covalent inhibitors of Botulinum Neurotoxin in JMedChem! pubs.acs.org/doi/10.1021/ac…
pubs.acs.org
Catch and Anchor Approach To Combat Both Toxicity and Longevity of Botulinum Toxin A
Botulinum neurotoxins have remarkable persistence (∼weeks to months in cells), outlasting the small-molecule inhibitors designed to target them. To address this disconnect, inhibitors bearing two...
We are features in the latest issue of Newsweek.
"The complexity of brain chemistry involved is extremely difficult to target with a drug. But if you have a good enough #antibody, it acts like a vacuum cleaner to suck the drug out of the brain." Prof. Kim Janda's immunopharmacotherapy for #addiction newsweek.com/2020/08/14/how…
"The complexity of brain chemistry involved is extremely difficult to target with a drug. But if you have a good enough #antibody, it acts like a vacuum cleaner to suck the drug out of the brain." Prof. Kim Janda's immunopharmacotherapy for #addiction newsweek.com/2020/08/14/how…
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