Pascoal Lab
@LabPascoal
Lab based at University of Pittsburgh interested in diagnostic and therapeutic approaches in neurodegeneration | PI: @TharickAPascoal
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In our new study @NatureComms, Dr Soares et al show that CSF total tau, often used as a marker of neurodegeneration, is more strongly linked to synaptic degeneration than axonal or neuronal loss in Alzheimer’s disease. Check our paper here🔗doi.org/10.1038/s41467…
We were very happy to receive Etienne Vachon-Presseau @evp82, Associate Professor at McGill, for a lab visit today! Etienne presented findings from analysis of UK Biobank data on prediction of chronic pain, including results from his group's recent papers…
I’m proud to share our systematic review & meta-analysis of plasma p-tau diagnostic accuracy studies :) thelancet.com/journals/laneu… Some highlights:
Paper 4: Insights into the use of biomarkers in clinical trials in Alzheimer's disease by @TharickAPascoal and colleagues: thelancet.com/journals/ebiom…
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Paper 4: Insights into the use of biomarkers in clinical trials in Alzheimer's disease by @TharickAPascoal and colleagues: thelancet.com/journals/ebiom…
We thank Dr Eric Siemers for his insightful comment on our recent publication, “Utility of Plasma GFAP as a Secondary Endpoint in AD Trials,” highlighting the growing potential of plasma GFAP in AD trials @LabPascoal @TharickAPascoal 👇👇👇 sciencedirect.com/science/articl…
Excellent presentation by #MarcoDeBastiani on a promising novel microglial biomarker linked to brain glucose metabolism at #AAIC25! @zimmerneurolab
Heading to #AAIC2025? We’re excited to share 9 oral presentations and 16 posters at this year’s conference! Come find us - we’d love to connect, discuss, and explore opportunities for collaboration.👇
New paper alert🚨 Our new study led by Dr @FrancieliRohden @NatureComms showed glial reactivity correlates with synaptic dysfunction in aging and AD, revealing how astrocyte and microglial activation influence synaptic degeneration. Check it now: nature.com/articles/s4146…
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