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Signoretti Lab

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We are looking for a JUNIOR PATHOLOGIST (at least 1 year of residency training) to join our group and lead one of our translational efforts in kidney cancer. Please contact us if you are interested and willing to spend at least 2 years in the lab.


Many congratulations Berkay Simsek for being a recipient of the KCRS 2025 Merit Awards for Translational Research @simsek_berkay_ @kidneycan @MassGenBrigham #KCRS25 #kidneycancer

LabSignoretti's tweet image. Many congratulations Berkay Simsek for being a recipient of the KCRS 2025 Merit Awards for Translational Research @simsek_berkay_ @kidneycan @MassGenBrigham   #KCRS25  #kidneycancer

Signoretti Lab 已轉發

The #KCRS2025@kidneycan⁩ is also about ART!

DrChoueiri's tweet image. The #KCRS2025 ⁦@kidneycan⁩ is also about ART!

Signoretti Lab 已轉發

#KCRS25 Oral Abstract: @simsek_berkay_ @BrighamWomens links CD163+ macrophages in RCC tumors to better outcomes with nivolumab. A potential new target for immunotherapy. Read all the abstracts: bit.ly/AbstractsKCRS25 Register: bit.ly/RegisterKCRS25 #AcceleratingCures

kidneycan's tweet image. #KCRS25 Oral Abstract: @simsek_berkay_ @BrighamWomens links CD163+ macrophages in RCC tumors to better outcomes with nivolumab. A potential new target for immunotherapy.

Read all the abstracts: bit.ly/AbstractsKCRS25
Register: bit.ly/RegisterKCRS25

#AcceleratingCures

Signoretti Lab 已轉發

Pathologist representation at this year’s #KCRS25, one of my most important and favorite meetings each year. 🔬🩺🩻 #gupathology #workingtogethertofightRCC @PayalKapur5 @Unclassified1 @drmehrarohit @kidneycan @OncoAlert @urotoday

MichelleDunno17's tweet image. Pathologist representation at this year’s #KCRS25, one of my most important and favorite meetings each year. 🔬🩺🩻 #gupathology #workingtogethertofightRCC @PayalKapur5 @Unclassified1 @drmehrarohit @kidneycan @OncoAlert @urotoday

Signoretti Lab 已轉發

So proud to be part of this incredible research team! #KCRS25 #pathology #kidneycancer @kidneycan

Gabriel_Pathol's tweet image. So proud to be part of this incredible research team! #KCRS25 #pathology #kidneycancer @kidneycan

Signoretti Lab 已轉發

We are looking for a JUNIOR PATHOLOGIST (at least 1 year of residency training) to join our group and lead one of our translational efforts in kidney cancer. Please contact us if you are interested and willing to spend at least 2 years in the lab.


Signoretti Lab 已轉發

Thanks to our friends at Cure Today for letting me share some advice for new patients. 👊👊 ⁦@DanaFarber⁩ ⁦@DrChoueiri⁩ ⁦@DanaFarber_GU⁩ ⁦@kidneycan⁩ ⁦@TheJimmyFund⁩ ⁦@DanaFarberNewscuretoday.com/view/finding-s…


Signoretti Lab 已轉發

Celebrating Dr Sabina Signoretti @BrighamWomens work and dedication over the years to @DanaFarber @BrighamWomens @df_hcc Pathology! cc: @LabSignoretti @kaelin_lab @harvardmed

DrChoueiri's tweet image. Celebrating Dr Sabina Signoretti @BrighamWomens work and dedication over the years to @DanaFarber @BrighamWomens @df_hcc Pathology! 

cc: @LabSignoretti @kaelin_lab @harvardmed

Signoretti Lab 已轉發

Phase 1/2 Design of the HIF2a inhibitor NKT2152-101 showed response rate of 20% with an ‘in class’ toxicity profile #ESMO24 . The long half like makes it distinct and there in now a dose to take to randomised trials. Advantages over belzurifan are unclear. 2 doses being pursued.

tompowles1's tweet image. Phase 1/2 Design of the HIF2a inhibitor NKT2152-101 showed response rate of 20% with an ‘in class’ toxicity profile #ESMO24 . The long half like makes it distinct and there in now a dose to take to randomised trials. Advantages over belzurifan are unclear. 2 doses being pursued.
tompowles1's tweet image. Phase 1/2 Design of the HIF2a inhibitor NKT2152-101 showed response rate of 20% with an ‘in class’ toxicity profile #ESMO24 . The long half like makes it distinct and there in now a dose to take to randomised trials. Advantages over belzurifan are unclear. 2 doses being pursued.
tompowles1's tweet image. Phase 1/2 Design of the HIF2a inhibitor NKT2152-101 showed response rate of 20% with an ‘in class’ toxicity profile #ESMO24 . The long half like makes it distinct and there in now a dose to take to randomised trials. Advantages over belzurifan are unclear. 2 doses being pursued.
tompowles1's tweet image. Phase 1/2 Design of the HIF2a inhibitor NKT2152-101 showed response rate of 20% with an ‘in class’ toxicity profile #ESMO24 . The long half like makes it distinct and there in now a dose to take to randomised trials. Advantages over belzurifan are unclear. 2 doses being pursued.

Signoretti Lab 已轉發

Sarcomatoid RCC #kidneycancer : Diagnostic Updates and Therapeutic Implications. Comprehensive talk by @SabinaSign16728 @BrighamWomens 👉epigenomics, genetics and inflammed phenotype of Sarcomatoid RCC & Rx implications #KCRS24 @kidneycan @DrChoueiri @TalalZarif1 @OncoAlert

neerajaiims's tweet image. Sarcomatoid RCC #kidneycancer : Diagnostic Updates and Therapeutic Implications. Comprehensive talk by @SabinaSign16728 @BrighamWomens 👉epigenomics, genetics and inflammed phenotype of Sarcomatoid RCC & Rx implications #KCRS24 @kidneycan @DrChoueiri @TalalZarif1 @OncoAlert
neerajaiims's tweet image. Sarcomatoid RCC #kidneycancer : Diagnostic Updates and Therapeutic Implications. Comprehensive talk by @SabinaSign16728 @BrighamWomens 👉epigenomics, genetics and inflammed phenotype of Sarcomatoid RCC & Rx implications #KCRS24 @kidneycan @DrChoueiri @TalalZarif1 @OncoAlert
neerajaiims's tweet image. Sarcomatoid RCC #kidneycancer : Diagnostic Updates and Therapeutic Implications. Comprehensive talk by @SabinaSign16728 @BrighamWomens 👉epigenomics, genetics and inflammed phenotype of Sarcomatoid RCC & Rx implications #KCRS24 @kidneycan @DrChoueiri @TalalZarif1 @OncoAlert
neerajaiims's tweet image. Sarcomatoid RCC #kidneycancer : Diagnostic Updates and Therapeutic Implications. Comprehensive talk by @SabinaSign16728 @BrighamWomens 👉epigenomics, genetics and inflammed phenotype of Sarcomatoid RCC & Rx implications #KCRS24 @kidneycan @DrChoueiri @TalalZarif1 @OncoAlert

Signoretti Lab 已轉發

Kicking off the Trials in Progress session with #ARCITECT evaluating Botensilimab+Balstilimab for pts with mRCC A trial that aims to "raise the tail" and a fantastic presentation by @MikeSerzanMD #KCRS24 @kidneycan @OncoAlert

ReneeSaliby's tweet image. Kicking off the Trials in Progress session with #ARCITECT evaluating Botensilimab+Balstilimab for pts with mRCC

A trial that aims to "raise the tail" and a fantastic presentation by @MikeSerzanMD 

#KCRS24 @kidneycan @OncoAlert
ReneeSaliby's tweet image. Kicking off the Trials in Progress session with #ARCITECT evaluating Botensilimab+Balstilimab for pts with mRCC

A trial that aims to "raise the tail" and a fantastic presentation by @MikeSerzanMD 

#KCRS24 @kidneycan @OncoAlert
ReneeSaliby's tweet image. Kicking off the Trials in Progress session with #ARCITECT evaluating Botensilimab+Balstilimab for pts with mRCC

A trial that aims to "raise the tail" and a fantastic presentation by @MikeSerzanMD 

#KCRS24 @kidneycan @OncoAlert

Signoretti Lab 已轉發

Great work from these presenters!

Wonderful Pathology session on KCRS - State of the Science. “This is an Exciting and a Fantastic time to be a Pathologist!” @kidneycan

Gabriel_Pathol's tweet image. Wonderful Pathology session on KCRS - State of the Science. “This is an Exciting and a Fantastic time to be a Pathologist!” @kidneycan


Signoretti Lab 已轉發

The #INTerpath-004 trial explores the combination of pembro + personalized mRNA #vaccine for the adjuvant treatment of pts with RCC. Inspiring talk by @DrChoueiri at #KCRS24! @kidneycan @DanaFarber_GU @OncLive

MarcMachaalani's tweet image. The #INTerpath-004 trial explores the combination of pembro + personalized mRNA #vaccine for the adjuvant treatment of pts with RCC. Inspiring talk by @DrChoueiri at #KCRS24!

@kidneycan @DanaFarber_GU @OncLive
MarcMachaalani's tweet image. The #INTerpath-004 trial explores the combination of pembro + personalized mRNA #vaccine for the adjuvant treatment of pts with RCC. Inspiring talk by @DrChoueiri at #KCRS24!

@kidneycan @DanaFarber_GU @OncLive
MarcMachaalani's tweet image. The #INTerpath-004 trial explores the combination of pembro + personalized mRNA #vaccine for the adjuvant treatment of pts with RCC. Inspiring talk by @DrChoueiri at #KCRS24!

@kidneycan @DanaFarber_GU @OncLive

Signoretti Lab 已轉發

🟢 Outstanding presentation at #KCRS24 @drmehrarohit 🟠 Role of Pathologist in Kidney Cancer Diagnostics and Research 🟠 Highlighting the morphologic diversity in renal tumors and its diagnostic implications. 🟠 Emphasis on understanding mechanisms to improve patient care.…

DrYukselUrun's tweet image. 🟢 Outstanding presentation at #KCRS24 @drmehrarohit 
🟠 Role of Pathologist in Kidney Cancer Diagnostics and Research
🟠 Highlighting the morphologic diversity in renal tumors and its diagnostic implications.
🟠 Emphasis on understanding mechanisms to improve patient care.…
DrYukselUrun's tweet image. 🟢 Outstanding presentation at #KCRS24 @drmehrarohit 
🟠 Role of Pathologist in Kidney Cancer Diagnostics and Research
🟠 Highlighting the morphologic diversity in renal tumors and its diagnostic implications.
🟠 Emphasis on understanding mechanisms to improve patient care.…
DrYukselUrun's tweet image. 🟢 Outstanding presentation at #KCRS24 @drmehrarohit 
🟠 Role of Pathologist in Kidney Cancer Diagnostics and Research
🟠 Highlighting the morphologic diversity in renal tumors and its diagnostic implications.
🟠 Emphasis on understanding mechanisms to improve patient care.…
DrYukselUrun's tweet image. 🟢 Outstanding presentation at #KCRS24 @drmehrarohit 
🟠 Role of Pathologist in Kidney Cancer Diagnostics and Research
🟠 Highlighting the morphologic diversity in renal tumors and its diagnostic implications.
🟠 Emphasis on understanding mechanisms to improve patient care.…

Signoretti Lab 已轉發

We are super interested in the IVC thrombus @UTSWUrology @utswcancer @UTSWHemeOnc! @PayalKapur5 shows IVC correlates and Angioscore for as a biomarker for angiogenic driven tumor. @KCPUTSW #KCRS24 @kidneycan

TiansterZhang's tweet image. We are super interested in the IVC thrombus @UTSWUrology @utswcancer @UTSWHemeOnc! @PayalKapur5 shows IVC correlates and Angioscore for as a biomarker for angiogenic driven tumor. @KCPUTSW #KCRS24 @kidneycan
TiansterZhang's tweet image. We are super interested in the IVC thrombus @UTSWUrology @utswcancer @UTSWHemeOnc! @PayalKapur5 shows IVC correlates and Angioscore for as a biomarker for angiogenic driven tumor. @KCPUTSW #KCRS24 @kidneycan
TiansterZhang's tweet image. We are super interested in the IVC thrombus @UTSWUrology @utswcancer @UTSWHemeOnc! @PayalKapur5 shows IVC correlates and Angioscore for as a biomarker for angiogenic driven tumor. @KCPUTSW #KCRS24 @kidneycan

Prognostic and Predictive Biomarkers in #kidneycancer Very insightful talk by @PayalKapur5 @UTSWMedCenter 👉Tumor thrombus grading predicts metastasis free survival better than primary RCc grading & more👇#KCRS24 @kidneycan @DrChoueiri @JBrugarolas @HHammersMD

neerajaiims's tweet image. Prognostic and Predictive Biomarkers in #kidneycancer Very insightful talk by @PayalKapur5 @UTSWMedCenter 👉Tumor thrombus grading predicts metastasis free survival better than primary RCc grading & more👇#KCRS24 @kidneycan @DrChoueiri @JBrugarolas @HHammersMD
neerajaiims's tweet image. Prognostic and Predictive Biomarkers in #kidneycancer Very insightful talk by @PayalKapur5 @UTSWMedCenter 👉Tumor thrombus grading predicts metastasis free survival better than primary RCc grading & more👇#KCRS24 @kidneycan @DrChoueiri @JBrugarolas @HHammersMD
neerajaiims's tweet image. Prognostic and Predictive Biomarkers in #kidneycancer Very insightful talk by @PayalKapur5 @UTSWMedCenter 👉Tumor thrombus grading predicts metastasis free survival better than primary RCc grading & more👇#KCRS24 @kidneycan @DrChoueiri @JBrugarolas @HHammersMD
neerajaiims's tweet image. Prognostic and Predictive Biomarkers in #kidneycancer Very insightful talk by @PayalKapur5 @UTSWMedCenter 👉Tumor thrombus grading predicts metastasis free survival better than primary RCc grading & more👇#KCRS24 @kidneycan @DrChoueiri @JBrugarolas @HHammersMD


Signoretti Lab 已轉發

Thank you Chuck for sharing! It’s very inspiring! Advocacy, research, and patient care unite to accelerate the cure! We can’t do it alone – we need each other! @kidneycan @DrChoueiri @advocatekidneys #KCRS24 @OncoAlert @CJSTRAV3 #Advocate @HHammersMD @neerajaiims @yekeduz_emre


Signoretti Lab 已轉發

Brilliant insights from @tompowles1 @QMBCI. Excellent use of Twitter polls to reconcile tough clinical scenarios (eg IO rechallenge following adj pembro). Shocking to hear rates of IO receipt in real world series - great point from Tom - use the best tx first. @DrChoueiri

montypal's tweet image. Brilliant insights from @tompowles1 @QMBCI. Excellent use of Twitter polls to reconcile tough clinical scenarios (eg IO rechallenge following adj pembro). Shocking to hear rates of IO receipt in real world series - great point from Tom - use the best tx first. @DrChoueiri…
montypal's tweet image. Brilliant insights from @tompowles1 @QMBCI. Excellent use of Twitter polls to reconcile tough clinical scenarios (eg IO rechallenge following adj pembro). Shocking to hear rates of IO receipt in real world series - great point from Tom - use the best tx first. @DrChoueiri…
montypal's tweet image. Brilliant insights from @tompowles1 @QMBCI. Excellent use of Twitter polls to reconcile tough clinical scenarios (eg IO rechallenge following adj pembro). Shocking to hear rates of IO receipt in real world series - great point from Tom - use the best tx first. @DrChoueiri…
montypal's tweet image. Brilliant insights from @tompowles1 @QMBCI. Excellent use of Twitter polls to reconcile tough clinical scenarios (eg IO rechallenge following adj pembro). Shocking to hear rates of IO receipt in real world series - great point from Tom - use the best tx first. @DrChoueiri…

Signoretti Lab 已轉發

#KCRS24 Session 8: Rapid Abstract Presentations are underway! Tertiary Lymphoid Structures in Sarcomatoid RCC @NickSalgia Brain-Specific Tropism in mRCC @rmelias2 Latino Ethnicity & Gut Microbiome in mRCC @ReginaBarCar #KidneyCancer #AcceleratingCures

kidneycan's tweet image. #KCRS24 Session 8: Rapid Abstract Presentations are underway!

Tertiary Lymphoid Structures in Sarcomatoid RCC @NickSalgia 
Brain-Specific Tropism in mRCC @rmelias2 
Latino Ethnicity & Gut Microbiome in mRCC @ReginaBarCar 

#KidneyCancer #AcceleratingCures
kidneycan's tweet image. #KCRS24 Session 8: Rapid Abstract Presentations are underway!

Tertiary Lymphoid Structures in Sarcomatoid RCC @NickSalgia 
Brain-Specific Tropism in mRCC @rmelias2 
Latino Ethnicity & Gut Microbiome in mRCC @ReginaBarCar 

#KidneyCancer #AcceleratingCures

Signoretti Lab 已轉發

Wrapping #kcrs24! Started my day with rock the run 5k and finished it with insightful discussions and inspiring moments. So glad to be part of kidney cancer research but also part of a great team along the way of curing this cancer!

Rzn_Mh's tweet image. Wrapping #kcrs24! 
Started my day with rock the run 5k and finished it with insightful discussions and inspiring moments. So glad to be part of kidney cancer research but also part of a great team along the way of curing this cancer!
Rzn_Mh's tweet image. Wrapping #kcrs24! 
Started my day with rock the run 5k and finished it with insightful discussions and inspiring moments. So glad to be part of kidney cancer research but also part of a great team along the way of curing this cancer!
Rzn_Mh's tweet image. Wrapping #kcrs24! 
Started my day with rock the run 5k and finished it with insightful discussions and inspiring moments. So glad to be part of kidney cancer research but also part of a great team along the way of curing this cancer!
Rzn_Mh's tweet image. Wrapping #kcrs24! 
Started my day with rock the run 5k and finished it with insightful discussions and inspiring moments. So glad to be part of kidney cancer research but also part of a great team along the way of curing this cancer!

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