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Does vitamin B12 play a role in Parkinson’s disease risk? What do the genes tell us? Vitamin B12 metabolism refers to how the body absorbs, transports and uses vitamin B12, which is essential for nerve function and energy production. Dering and colleagues describe in a new paper
Left: #valsartan vs placebo in HFrEF (truncated y axis ) Right: #enalapril vs placebo in HFrEF Same primary outcome Enalapril/ACEi then considered gold standard in HFrEF Therefore, appropriate comparator for a new RAASi+ in a #HFrEF RCT in 2009 would be.. ?? #TrialDesign
👉 Residual lipid risk in atherosclerotic cardiovascular disease 🙌 MUST READ 1️⃣ Why this matters (still underestimated): Even with optimal LDL-C lowering → residual lipid risk persists. Explains recurrent ASCVD despite “guideline-at-goal” LDL. 2️⃣ Three causal lipid players
New autoantibodies in Sjögren's disease #Rheumatology #MedTwitter These findings strongly suggest that a multi-marker panel approach is the most promising strategy for developing a new diagnostic test for seronegative SjD…
Does cancer screening increase lifespan? open.substack.com/pub/breakinggr… via @DrSamuelBHume @susan_bewley @MichaelBaum11 @naserturabi
Very high lipoprotein(a) levels are associated with increased 30-year risk of major #cardiovascular events, coronary heart disease, ischemic #stroke, and cardiovascular death among healthy women. ja.ma/4kcZvAm
In this study, nebivolol offers better BP control and lower cardiovascular risk than other beta-blockers. ahajrnls.org/4azyWB7
🧬Gene Editing Therapies Targeting Lipid Metabolism for Cardiovascular Disease: Tools, Delivery Strategies, and Clinical Progress 1️⃣ PCSK9 LDL-C ↓ via sustained LDLR recycling Proof-of-concept strongest (human genetics → drugs → editing) 2️⃣ ANGPTL3 TG ↓ + LDL-C ↓ (LPL
Our new article on Lp(a) lowering is just published @MeralKayikcoglu @ProfKausikRay @TKDsosyal @DrMarthaGulati @EugeniaGianos Lipoprotein(a)-lowering therapies: a promising future academic.oup.com/eurheartj/arti…
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Mineralocorticoid Receptor Antagonist Use in Hypertension to Prevent Heart Failure MRAs may be undervalued for the treatment of hypertension and prevention of HF. The implementation of MRA therapy in earlier phases of hypertension may prevent the incidence of HF by addressing
🫀 Treat-to-Plaque Starts with Seeing Plaque Why Photon-Counting CT + High-Iodine Contrast Are Enabling a New Preventive Strategy TRUE Ultra-High spatial resolution TRUE Ultra-High temporal resolution TRUE Ultra-High contrast resolution For decades, we treated numbers: LDL,
Quadruple vs triple therapy for resistant hypertension: the QUADRO trial The first full-dose quadruple antihypertensive SPC (perindopril/indapamide/amlodipine/bisoprolol) demonstrated superiority over perindopril/indapamide/amlodipine, offering an effective alternative therapy
Valacyclovir was associated with greater cognitive decline and did not improve disease markers in patients with symptomatic #AlzheimerDisease and HSV seropositivity. bit.ly/3O6Er2w
MiniMax just dropped M2.5: - 80.2% SWE-Bench (beats Opus 4.6) - 37% faster than M2.1 - $1/hr at 100 tokens/sec - cheaper than Opus 4.6 - it’s open source.
Introducing M2.5, an open-source frontier model designed for real-world productivity. - SOTA performance at coding (SWE-Bench Verified 80.2%), search (BrowseComp 76.3%), agentic tool-calling (BFCL 76.8%) & office work. - Optimized for efficient execution, 37% faster at complex
What’s the lowest LDL you’ve seen? For everyone shouting that “statins are harmful” and spreading half-baked misinformation… Here’s mine. Yes u read it right MY lipid profile LDL: 9 mg/dL. Yes ! single digit. On a Rosuvastatin for last 3 years. Intermediate ASCVD risk.
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