Matrix_Science's profile picture. Mascot: The trusted reference standard for protein identification by mass spectrometry for 25 years

Matrix Science (@matrixscience.bsky.social)

@Matrix_Science

Mascot: The trusted reference standard for protein identification by mass spectrometry for 25 years

The DDoS attack on matrixscience.com appears to be over. Functionality has been resumed and we will continue monitoring the system.


The free Mascot service at matrixscience.com is currently being hammered by a distributed denial of service (DDoS) attack. The incident started around 11:00 GMT. We have mitigated the attack, which means some Mascot functionality is unavailable for now.


Mascot Newsletter, October 2025: Spectrum-centric DIA scoring. Molecular mechanisms of SBK2 kinase on the heart. Windows update issue with IIS (resolved). matrixscience.com/nl/202510/news… #proteomics #massspec

Matrix_Science's tweet image. Mascot Newsletter, October 2025:

Spectrum-centric DIA scoring.

Molecular mechanisms of SBK2 kinase on the heart.

Windows update issue with IIS (resolved).

matrixscience.com/nl/202510/news…

#proteomics #massspec

Mascot Daemon can export protein level quant intensities for replicate LFQ, SILAC and iTRAQ/TMT. The latest version can also export intensity values calculated using the "Top-3" method, illustrated here with DDA-PASEF data. matrixscience.com/blog/top-3-qua… #proteomics #massspec


We are pleased to announce a new distributor for Matrix Science products! Customers in India can now buy Mascot Server through BioInnovations, who provide products and services for life sciences and analytical and clinical labs. #proteomics #massspec matrixscience.com/whats_new/new-…


Probabilistic scoring of DIA matches without spectral deconvolution? Not only is it possible, we're working on implementing it in Mascot DIA. matrixscience.com/blog/probabili… #proteomics #massspec

Matrix_Science's tweet image. Probabilistic scoring of DIA matches without spectral deconvolution? Not only is it possible, we're working on implementing it in Mascot DIA.

matrixscience.com/blog/probabili…

#proteomics #massspec

Mascot Newsletter, August 2025: Precursor detection for spectrum-centric DIA. Reconstructing mediaeval monastic diets. Microsoft has announced the end of Windows 10 support; your Mascot Server may be affected. matrixscience.com/nl/202508/news… #proteomics #massspec

Matrix_Science's tweet image. Mascot Newsletter, August 2025:

Precursor detection for spectrum-centric DIA.

Reconstructing mediaeval monastic diets.

Microsoft has announced the end of Windows 10 support; your Mascot Server may be affected.

matrixscience.com/nl/202508/news…

#proteomics #massspec

Peptide identification in spectrum-centric DIA depends on accurate precursor mass. The upcoming version of Mascot Distiller includes a novel algorithm that deduces precursor masses from MS/MS scans. #proteomics #massspec matrixscience.com/blog/youve-got…

Matrix_Science's tweet image. Peptide identification in spectrum-centric DIA depends on accurate precursor mass. The upcoming version of Mascot Distiller includes a novel algorithm that deduces precursor masses from MS/MS scans.

#proteomics #massspec

matrixscience.com/blog/youve-got…

Mascot Newsletter, July 2025: Overview of spectrum-centric DIA and Mascot DIA. Metaproteomics of bacterioplankton communities. New pricing tiers for Mascot Server, and price reduction when updating from an old version. matrixscience.com/nl/202507/news… #proteomics #massspec

Matrix_Science's tweet image. Mascot Newsletter, July 2025:

Overview of spectrum-centric DIA and Mascot DIA.

Metaproteomics of bacterioplankton communities.

New pricing tiers for Mascot Server, and price reduction when updating from an old version.

matrixscience.com/nl/202507/news…

#proteomics #massspec

We are working on Mascot DIA, which is a universal spectrum-centric solution for DIA analysis. What is spectrum-centric searching meant to solve? Find out in our blog: matrixscience.com/blog/the-promi… #proteomics #massspec

Matrix_Science's tweet image. We are working on Mascot DIA, which is a universal spectrum-centric solution for DIA analysis. What is spectrum-centric searching meant to solve? Find out in our blog:

matrixscience.com/blog/the-promi…

#proteomics #massspec

Mascot Newsletter, June 2025: Annual user meeting summary and preview of Mascot DIA. ASMS posters using Mascot: forensics, cancer research, food science, fish, ... Matrix Science posters on LFQ and machine learning. matrixscience.com/nl/202506/news… #proteomics #massspec

Matrix_Science's tweet image. Mascot Newsletter, June 2025:

Annual user meeting summary and preview of Mascot DIA.

ASMS posters using Mascot: forensics, cancer research, food science, fish, ...

Matrix Science posters on LFQ and machine learning.

matrixscience.com/nl/202506/news…

#proteomics #massspec

Come see our poster ThP 265 today at #ASMS2025: Machine learning-enabled Mascot Server API improves LFQ in client software like Thermo Proteome Discoverer


Pick up a free Matrix Science pen, bag or notebook from #ASMS2025 booth #334 -- while stocks last!

Matrix_Science's tweet image. Pick up a free Matrix Science pen, bag or notebook from #ASMS2025 booth #334 -- while stocks last!

Come see our poster TP 505 today at #ASMS2025 : Customizable machine learning adapter improves LFQ in Mascot Distiller


Register now for the Matrix Science Breakfast Meeting at #ASMS2025 on 2nd June: matrixscience.com/workshop.html There is no charge for attending the meeting, but advance registration is required. #proteomics #MassSpec

Matrix_Science's tweet image. Register now for the Matrix Science Breakfast Meeting at #ASMS2025 on 2nd June: matrixscience.com/workshop.html

There is no charge for attending the meeting, but advance registration is required. #proteomics #MassSpec

When you refine results with Mascot Server and import into Thermo Proteome Discoverer, you should disable MudPIT scoring. This makes the Protein FDR Validator node much happier. matrixscience.com/blog/identify-… #proteomics #MassSpec

Matrix_Science's tweet image. When you refine results with Mascot Server and import into Thermo Proteome Discoverer, you should disable MudPIT scoring. This makes the Protein FDR Validator node much happier.

matrixscience.com/blog/identify-…

#proteomics #MassSpec

Register now for the Matrix Science Breakfast Meeting at #ASMS2025 on 2nd June: matrixscience.com/workshop.html There is no charge for attending the meeting, but advance registration is required. #proteomics #MassSpec

Matrix_Science's tweet image. Register now for the Matrix Science Breakfast Meeting at #ASMS2025 on 2nd June: matrixscience.com/workshop.html

There is no charge for attending the meeting, but advance registration is required. #proteomics #MassSpec

Mascot newsletter, May 2025: ASMS User Meeting registration is open. Oxygen metabolism in horses. Big databases and large peak lists. matrixscience.com/nl/202505/news… #proteomics #massspec

Matrix_Science's tweet image. Mascot newsletter, May 2025:

ASMS User Meeting registration is open.

Oxygen metabolism in horses.

Big databases and large peak lists.

matrixscience.com/nl/202505/news…

#proteomics #massspec

Register now for the Matrix Science Breakfast Meeting at #ASMS2025 on 2nd June: matrixscience.com/workshop.html There is no charge for attending the meeting, but advance registration is required. #proteomics #MassSpec

Matrix_Science's tweet image. Register now for the Matrix Science Breakfast Meeting at #ASMS2025 on 2nd June: matrixscience.com/workshop.html

There is no charge for attending the meeting, but advance registration is required. #proteomics #MassSpec

Mascot Server ships with MS2Rescore, which is one of many predictive ML tools for proteomics. Follow this new tutorial if you want to add an integration to a different AI/ML system. matrixscience.com/blog/adding-a-… #proteomics #MassSpec

Matrix_Science's tweet image. Mascot Server ships with MS2Rescore, which is one of many predictive ML tools for proteomics. Follow this new tutorial if you want to add an integration to a different AI/ML system.

matrixscience.com/blog/adding-a-…

#proteomics #MassSpec

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