Michael Ewers
@MichaelEwers12
Researcher at the ISD, Ludwig Maximilian University. Interested in cognitive resilience/reserve, tau spreading and neuroinflammation in Alzheimer's
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Carolina Valentim presented our exciting finding of synaptic pathway-specific polygenic risk scores that enhance amyloid related tau-PET increases in AD - today at ADPD. #ADPD2025
Clearly a setback for patients and the research community in Europe. We need to encourage a well-informed decision process by doctors and patients rather than blocking access. Leqembi | European Medicines Agency ema.europa.eu/en/medicines/h…
ema.europa.eu
Leqembi | European Medicines Agency (EMA)
Leqembi | European Medicines Agency (EMA)
Please join this phantastic work shop in Philly before AAIC. There a still spots left!
New paper on connectomics, MAPT gene expression and amyoid PET to explain regional tau PET! tinyurl.com/22papw8x. Dovetails with our proposed model in @NatRevNeurosci tinyurl.com/2vs8ah23. Special thanks to @zhenglukai, @nfranzme, @biofinder_study, and @EliLillyandCo
Great start of AIC by year-in-review presented by Indira Turney. Shows importance of sex and racial differences in imaging markers of AD.#AAIC2023
My hunch is this new lesion connectome-predictive modeling approach by @jfjiang published yesterday in @NatureComms will become the next generation of lesion network mapping. Seems very promising at this early stage. nature.com/articles/s4146…
It's time for de Leon prizes for neuroimaging papers! (Self-)Nominate papers and/or join the voting committee! Deadline: March 13 Submit the best neuroimaging papers from 2022: alz.surveymonkey.com/r/JM5JPPK Join the voting committe: alz.surveymonkey.com/r/3XB6VLP
We welcome @US_FDA’s accelerated approval of lecanemab for treatment of the early stages of Alzheimer’s with confirmation of amyloid beta, and strongly renew our call for @CMSgov to cover FDA-approved Alzheimer’s treatments. Read our full statement:alz.org/news/2023/leca…
alz.org
Alzheimer’s Association Welcomes U.S. FDA Approval of Lecanemab
The Alzheimer's Association welcomes the news that Lecanemab (Leqembi) received accelerated approval from the FDA as a treatment for Alzheimer's disease.
Our new paper shows polygenic risk score comprising 85 lead AD-risk SNPs to be associated with enhanced effect of amyloid on the rate of tau PET accumulation, and cognitive decline. Thanks to lead author @AnnaRubinski & @rainermpg, Simon Frerich @nfranzme tinyurl.com/576vd4um
We are hiring!! PhD/Post-doc in -Multimodal neuroimaging in Alzheimer’s disease -European consortium on imaging & blood markers -Collaboration on AI based image analysis. -Neurogenetics Check out isd-research.de/ewers-lab and apply now!
Please join this exciting session. We will start in about 30 min at 5.30 pm MEZ.
Still time to sign up for our upcoming webinar on Dec. 7 on fMRI and FDG-PET!
In this study published in @NatureAging: nature.com/articles/s4358… we measured sTREM2 and the DAM2 markers AXL, MERTK, GAS6, LPL, CST7, SPP1 and CSF1 in the CSF of non-demented individuals, who underwent longitudinal amyloid-PET, tau-PET and cognitive assessment.
We are happy to present our new article by @JoanaBPereira1 et al. published in @NatureAging: nature.com/articles/s4358… showing that disease-associated microglial stage 2 (DAM2) markers predict slower tau accumulation and cognitive decline.
Just out in @NatRevNeurol! With @mmonje, @ankitakbatra, @hjxu1992. We review key discoveries & remaining questions to understand how myelin plasticity supports normal function & becomes dysregulated in neurological diseases. Check it out! @Stanford_Neuro nature.com/articles/s4158…
Very happy that our paper is now out in @AlzheimersRes where we show that higher levels of #myelin are associated with higher resistance against #tau pathology in #AlzheimersDisease. Many thanks to @MichaelEwers12 @nfranzme @biofinder_study and others! alzres.biomedcentral.com/articles/10.11…
The Alzheimer's Association appropriate use recommendations for blood biomarkers in AD were published today, and presented at #AAIC2022. They outline how BBMs can be used already today in the clinic and trials, and what additional studies are needed. bit.ly/3ONYhdJ
Join our virtual session on "Myelin changes and associated microglia activation as drivers of Alzheimer’s disease" today at 11.15 am PDT #AAIC2022 . Talks by A. Kohli from @BendlinLab @ConstanzeDepp Oskar Harari @omharari and twitterless Mikael Simons @DZNE_en
Very excited about these results. Congrats to @AnnaRubinski and many thanks to @biofinder_study for the great collaboration.
Very happy to share our latest preprint, showing that higher levels of #myelin are associated with higher resistance against #tau pathology in #Alzheimers disease. Many thanks to @MichaelEwers12 @nfranzme @biofinder_study and others! tinyurl.com/bdd455xv
Very happy to share our latest preprint, showing that higher levels of #myelin are associated with higher resistance against #tau pathology in #Alzheimers disease. Many thanks to @MichaelEwers12 @nfranzme @biofinder_study and others! tinyurl.com/bdd455xv
Happy to share our new work out in @NatureComms: Tau deposition patterns are associated with functional connectivity in 4R tauopathies, using PET and post-mortem data. Thanks to co-first author @matbrendel, @MichaelEwers12 @GunterHoglinger and many others! rdcu.be/cI029
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