PCF_SELECT
@PCF_select
Multidisciplinary team working together to develop, validate, and implement liquid biopsies to improve the lives of patients with prostate cancer.
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.@PCF_SELECT #cfDNA assay detects #allelicimbalance (e.g. BRCA2, ATM, PTEN) in #prostatecancer plasma with high sensitivity. Consortium of @FrancescaBZNY @AttardLab @mishabeltran @ResearchWyatt @MarkARubin1 labs and teams! @PCF_Science @AIRC_it @CR_UK academic.oup.com/narcancer/arti…
Understanding ctDNA technology applications for cancer detection and characterization. @ResearchWyatt @VanProstateCtr joins @UroDocAsh @MDAndersonNews to break down the fundamentals of cell-free DNA and how ctDNA represents the tumor-derived portion of these fragments in the…
Intraindividual epigenetic heterogeneity underlying phenotypic subtypes of advanced prostate cancer @NatureComms rdcu.be/euijO Team science led by Kei Mizuno #BeltranLab @DanaFarber_GU @PCF_Science
Favorite study! Germline-somatic tandems dictate cancer subtypes, provide clinical insights, and fuel molecularly informed studies. Kudos: Blerta Stringa, @Paola_Gasperini, Alessandro Alaimo, and @LunardiLabCIBIO (co-last a!) @NimaSharifiMD doi.org/10.1158/2159-8… @UniTrento
Stunning research from @EdmondMKwan on ctDNA in theranostics: 🧬Low ctDNA predicts better response with ¹⁷⁷Lu-PSMA-617 vs. cabazitaxel chemotherapy ⚠️PTEN alterations linked to worse outcomes on cabazitaxel 🧪ATM defects tied to favorable PSMA-617 results 🩻PET quantitative…
Elegant presentation from @ResearchWyatt on the evolution of ctDNA detection and characterization! Session chaired by @DanaFarber_GU's @OncoBellmunt and @BartsECMC 's @b_szabados #GU25 @ASCO @OncoAlert @OncLive
Exciting work ahead on Large #Oncosomes at the @UniTrento @CIBIO_UniTrento with our team #DemichelisLab, Dolores Di Vizio @doldivizio at @CedarsSinai and Shannon Stott @svploeg at @MGH_RI funded by the @theNCI #PLUS
@doldivizio is the lead PI on the NCI grant ‘Phenotyping Large #Oncosomes for Ultimate Evaluation of Patients Status’ (PLUS) to develop a #prostatecancer liquid biopsy assay with co-PIs @FrancescaBZNY & @svploeg. Congratulations Dr. Di Vizio & team! @theNCI
Proud of our LIG1 loss/PARP inhibition #SL study in @jclinicalinvest by @GiuliaFracassi_ an @AIRC_it fellowship awardee and @FraLo05 a @PCF_Science YIA Collaborators: @quimmateo @FdAdF66 Relevant to #prostatecancer and beyond. Download it! jci.org/articles/view/…
🚨 New Preprint Alert! 🚨 I’m thrilled to share our latest study now online on JCI: CRISPR/Cas9 screens identify LIG1 as a sensitizer of PARP inhibitors in castration-resistant prostate cancer. 🔬 Check out the preprint here: doi.org/10.1172/JCI179… Huge thanks to…
PROSTATE Paper 2 Franseschini et al. developed a targeted DNA methylation assay for the detection of neuroendocrine prostate cancer using plasma cell-free DNA with an AUC > 0.93. Their assay also quantifies tumor content and offers a phenotype evidence score, which reflects…
💔😞 RIP, my friend @felixfengmd Please consider donating to the @AmericanCancer @ASTRO_org Felix Feng MD Clinician Scientist Grant Award. Let his incredible legacy live on. donate.cancer.org/g/tjjfqwdnrxrl…
A man who deserved the two standing ovations regardless of his own cancer journey. @felixfengmd: “I just want to thank my friends” and “Behind every clinical trial is a patient like me. Thank you.” #PCFRetreat24
Heartbroken💔we lost Dr. Felix Feng— close friend, selfless collaborator, brilliant scientist & a man who saved many prostate cancer lives with a triad of generosity, kindness, & teamwork. We miss you @felixfengmd --too early my friend. To all: please consider supporting this…
Felix was the best of us. I'm heartbroken by his passing.💔His spirit of generosity, kindness, humility, his humor, intelligence & scientific acumen - you made us better scientists & better people, Felix. Love & miss you always. My deepest condolences to @MaryFengMD & family.🙏♥️
Tonight we sit with the cherished memories of a truly unforgettable individual who changed the lives of so many fighting cancer. Tomorrow we stand and get back to the fight against the terrible disease that took one of our best, brightest, and kindest. Love you forever, Felix.
The last time Felix stood on our stage, after a beautiful talk by @mishabeltran & intro by @AminaZoubeidi 💔💔💔 vimeo.com/1037583309/b7d…
vimeo.com
Vimeo
Dr. Felix Feng Special Lecture: Science and Friendship
Felix was the best of us. I'm heartbroken by his passing.💔His spirit of generosity, kindness, humility, his humor, intelligence & scientific acumen - you made us better scientists & better people, Felix. Love & miss you always. My deepest condolences to @MaryFengMD & family.🙏♥️
A tremendous loss for the cancer scientific community. @felixfengmd truly was one of the very best. I feel fortunate to have had the chance to meet him. This is heartbreaking but I want to remember him with the smile that always lit up his face 💔@MaryFengMD 💔
Tonight we sit with the cherished memories of a truly unforgettable individual who changed the lives of so many fighting cancer. Tomorrow we stand and get back to the fight against the terrible disease that took one of our best, brightest, and kindest. Love you forever, Felix.
Exciting news! Dr. Alex Wyatt, a senior research scientist at the Vancouver Prostate Centre, is now the scientific director for the Clinical Cancer Genomics Program at BC Cancer. @ResearchWyatt prostatecentre.com/news/dr-alex-w…
@mishabeltran sharing DLL3 PET/CT images including correlation with PSMA and FDG from @morr316 @PCF_Science TACTICAL grant #ESMO24 @myESMO
We are so proud to announce the recipients of the BCAN 2024 Research Innovation Awards, @FaltasLab of @WeillCornell and @ResearchWyatt of @UBC. We encourage you to read more about their innovative proposals here: bcan.org/2024-bladder-c…. Congratulations Drs. Faltas and Wyatt!
Check out our new review in @NatRevUrol on biologic determinants of PSMA expression, regulation, and heterogeneity in prostate cancer led by @mkbakht @DanaFarber_GU @PCF_Science Link to paper: rdcu.be/dM7GF nature.com/articles/s4158…
Announcement of new @felixfengmd Endowed @ASCO YIA by President-Elect Eric Small This is amazing. Huge tribute to the super friend, mentor, far-sighted, generous, leader, trailblazer and kindest! #FengSymposium PLEASE DONATE p2p.conquer.org/uniteandconque… @ConquerCancerFd
Prostate SPORE Retreat 2024 @felixfengmd @AminaZoubeidi @JoshLangMD @PCF_Science
Our latest on ctDNA% in mCRPC in @NatureComms: we affirm the independent strong prognostic implications & present a tool for predicting pre-blood draw whether ctDNA% is sufficiently high for genomic biomarker testing (e.g. BRCA2). Thread 👇. 1/n nature.com/articles/s4146…
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