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BREAKING: Shocking transcripts reveal that former White House staffer Cassidy Hutchinson told the Jan. 6th committee that she saw Trump’s Chief of Staff Mark Meadows burning documents in a fireplace “once or twice a week.” RT TO DEMAND THAT MEADOWS TESTIFY UNDER OATH TO EXPLAIN!
🖊️5-aminosalicylic acid (5-ASA) has both anti-inflammatory and immunosuppressant effects. It is the active compound of aminosalicylates - such as mesalamine; a drug used in the treatment of ulcerative colitis. Brands: ▪️ Apriso ▪️ Asacol HD ▪️ Delzicol ▪️ Lialda ▪️ Pentasa
This photo of President Biden is so badass.
🧵We've pulled together some of the false claims about crime and incarceration you're most likely to hear at the Thanksgiving dinner table, and the data and facts to help you push back:
🖊️Amiloride works by blocking ENaC - the epithelial sodium channel - in the distal tubule, connecting tubule, and collecting duct of the nephron. This reduces absorption of Na ions from the lumen of the nephron. It also reduces elimination of K ions into the lumen.
🖊️Tranexamic Acid l Revision Tranexamic acid prevents enzymes in the body from breaking down blood clots. 🛒Brand: Cyklokapron ✔️Usual Adult Dose for Bleeding ▪️ 10 mg/kg IV (before dental extraction) ▪️ Maintenance dose: 10 mg/kg IV 3-4 times daily ▪️ Duration: 2-8 days
🖊️Penicillamine is a drug used in the treatment of Wilson's disease. Wilson's disease is rare - with an estimated 1 in 30,000 people worldwide having it. Wilson's disease is an inherited disorder that causes copper to accumulate in the liver, brain and other vital organs.
🖊️SNRIs 👉indications include depression, fibromyalgia, anxiety disorders, and neuropathic pain. ▪️ venlafaxine - Effexor XR ® ▪️ desvenlafaxine - Pristiq ® ▪️ duloxetine - Cymbalta ® ▪️ milnacipran - Savella ® ▪️ levomilnacipran - Fetzima ® #naplex #pharmacy #pharmacology
🖊️Dopamine blockade in the nigrostriatal pathway can produce extrapyramidal effects such as: ▪️ acute dyskinesias ▪️ dystonic reactions ▪️ tardive dyskinesia ▪️ Parkinsonism ▪️ akinesia ▪️ akathisia ▪️ neuroleptic malignant syndrome
📢Nitrofurantoin Side Effects ✔️peripheral neuropathy ✔️elevated liver enzymes ✔️hemolytic anemia ✔️gastrointestinal upset ✔️pulmonary fibrosis ✔️brown urine
◾️ Loperamide Contraindications Loperamide should be avoided in patients with: 1. dysentery 2. who have abdominal pain in the absence of diarrhea 3. and / or in patients with severe ulcerative colitis ❌Loperamide is also contraindicated in patients younger than 2 years.
➰Basiliximab Basiliximab binds to the alpha subunit of the IL-2 receptor of activated T-cells. It prevents T-cell proliferation. Basiliximab is used to prevent organ transplant rejection, particularly kidney transplants.
🖊️Baricitinib Baricitinib is a drug used to treat rheumatoid arthritis. It has also been used in the management of COVID-19 disease. It works as an inhibitor of JAK1 and JAK2. Brand: ▪️ Olumiant Route of administration: Oral ✖️It can cause hypercholesterolemia
🖊️Pralidoxime chloride Pralidoxime chloride (2-PAM) is an antidote which, when given alongside atropine, is used to reverse the effects of: ▪️ organophosphate insecticides ▪️ nerve agents ▪️ some poisonous mushrooms
🖊️Symptoms of salicylate poisoning include tinnitus, hyperventilation and sweating. Gastric lavage, up to 1hr after ingestion; is followed by activated charcoal. Severe poisoning (plasma conc > 500mg / L-1) requires urinary alkalinization. Hemodialysis in the most severe cases.
🖊️Methotrexate Mechanisms! ▪️ MECHANISM 1 Inhibition of dihydrofolate synthetase. FH4 is required for DNA / protein synthesis, hence MTX's efficacy against cancer. ▪️ MECHANISM 2 Inhibition of IL-6, IL-8, TNF-alpha. Anti-inflammatory and immunosuppressant effects.
🖊️Secukinumab ▪️ active ingredient of the medicine, Cosentyx ▪️ works by inhibiting IL-17 ▪️ given via the subcutaneous route ▪️ used to treat psoriasis, ankylosing spondylitis, and psoriatic arthritis ▪️ >10% of patients experience respiratory tract infections with its use
🖊️Benzodiazepine Types (2/2) 👉7-nitro compounds: ▪️ clonazepam ▪️ flunitrazepam ▪️ nitrazepam 👉Triazolo compounds: ▪️ alprazolam ▪️ estazolam ▪️ triazolam 👉Imidazo compounds: ▪️ midazolam 👉1,5-benzodiazepines: ▪️ clobazam
🖊️Benzodiazepine Types (1/2) 👉2-keto compounds: ▪️ clorazepate ▪️ diazepam ▪️ flurazepam 👉3-hydroxy compounds: ▪️ lorazepam ▪️ oxazepam ▪️ temazepam
🖊️Metformin is contraindicated in patients with severe renal impairment due to the risk of lactic acidosis. Dose reduction is required for patients with moderate renal impairment. Metformin should be withheld in patients with acute kidney injury or severe tissue hypoxia.
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