PlemperLab
@PlemperLab
Plemper lab at Georgia State University. We study RNA viruses and develop antiviral therapeutics.
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Work was led by co-first authors @Robcox_science and Josef Wolf. Excellent use of the ferret model to study #molnupiravir efficacy and effect on SARS-CoV-2 transmission. rdcu.be/cbEjz
Excited to see our paper on blocking SARS-CoV-2 transmission with #EIDD-2801 (#molnupiravir) in @NatureMicrobiol. Study shows that orally administered #molnupiravir is efficacious against SARS-CoV-2 in ferrets and efficiently prevents virus spread to untreated contact ferrets.
A new antiviral drug that fights against a broad range of human pathogens in the paramyxovirus family, including the measles virus, has been discovered by Georgia State biomedical researchers. That's science #TheStateWay! ow.ly/Gs0V50AymEk
And many thanks to @anice_lowen, who worked with us on the 2018 study and used her guinea pig transmission model to demonstrate that the drug effectively suppresses virus spread between animals.
3/n: This #EIDD2801 is the same drug that shows promising efficacy against the #COVID19 virus (#SARSCoV2) in bit.ly/3cqhLSN. Great job @timothysheahan @Baric_Lab 👍 #ittakesavillage Richard Plemper laid the groundwork so #EIDD2801 can now be in clinical trials!
#COVID19 #Treatment 2/n: In 2019, he led the group that made an even better version, #EIDD2801, that showed all the good properties you want in a drug for clinical development (Sci Trans Med Oct 2019 bit.ly/2RJeBBH. 👇...
44% (95% CI, 25–69%) of secondary #COVID19 cases acquired during presymptomatic stage of primary #COVID19 transmitter. | “Disease control measures should be adjusted to account for probable substantial presymptomatic transmission.” Just read abstract. 😷 nature.com/articles/s4159…
nature.com
Temporal dynamics in viral shedding and transmissibility of COVID-19
Nature Medicine - Presymptomatic transmission of SARS-CoV-2 is estimated to account for a substantial proportion of COVID-19 cases.
Could SARS-CoV-2 be transmitted via speech droplets? In @NEJM letter, early tests from #NIH @NIDDKgov researchers show droplets expelled while talking. #COVID19 #COVID19talking nejm.org/doi/full/10.10…
Millions of Children Are at Risk for Measles as Coronavirus Fears Halt Vaccines nytimes.com/2020/04/13/hea…
nytimes.com
Millions of Children Are at Risk for Measles as Coronavirus Fears Halt Vaccines (Published 2020)
U.N. and global health experts warned that poor countries around the world were having to stop mass immunization programs to reduce the risk of spreading Covid-19.
Georgia State Biomedical Scientists Join the Global Race to Fight COVID-19 news.gsu.edu/2020/04/07/geo…
Fueled by the burden of #COVID19, #Measles cases are surging. Could antiviral therapeutics complement vaccination efforts to achieve measles elimination? Here is our current opinion on Measles Resurgence and Drug Development. #ERDRP0519 sciencedirect.com/science/articl…
Great work, the interplay between the nucleocapsid and polymerase of viruses of the mononegavirales order is fascinating, and it seems we're now learning more about it in Ebola virus as well biorxiv.org/content/10.110…
Paramyxoviruses nucleocapsid cores could have conserved a direct interface with the polymerase reminiscent of pneumoviruses, in spite of their long disordered C-terminal tail! Still wondering how the whole machinery moves. advances.sciencemag.org/content/6/10/e…
So exciting! Our influenza inhibitor #EIDD2801 repurposed against SARS-CoV-2. Starting clinical trials this week. Big shout out to Mart @TootsMart for his animal and human airway organoid work showing efficacy. ncbi.nlm.nih.gov/pubmed/31645453
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