PostViralCFS's profile picture. We are in need of prognostic markers & therapeutic targets for ME/CFS

Post Viral ME/CFS

@PostViralCFS

We are in need of prognostic markers & therapeutic targets for ME/CFS

Post Viral ME/CFS reposted

The gut<->brain axis impact on health and disease is far more important than anticipated, as reflected by GLP-1 effects, modulating the immune system, direct neural circuits, the microbiome, and more. A stellar new, open-access review @jclinicalinvest @ZachLorschMDPhD

EricTopol's tweet image. The gut&amp;lt;-&amp;gt;brain axis impact on health and disease is far more important than anticipated, as reflected by GLP-1 effects, modulating the immune system, direct neural circuits, the microbiome, and more. A stellar new, open-access review @jclinicalinvest @ZachLorschMDPhD…

Post Viral ME/CFS reposted

Great win early in the year to receive notification that our case series looking into Dr Pridgen’s Valacyclovir, Celecoxib and Paxlovid protocol seems to really help some folks with #LongCOVID. This paper is a start, not the be-all and end-all: frontiersin.org/journals/immun… 1/


Post Viral ME/CFS reposted

I thought I would repost this to highlight again some of the many varied symptoms that can be found in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Particularly relevant when similarities with the #LongCovid presentation in some people are being missed #MEcfs 1/

TomKindlon's tweet image. I thought I would repost this to highlight again some of the many varied symptoms that can be found in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome 

Particularly relevant when similarities with the #LongCovid presentation in some people are being missed

#MEcfs

1/

Post Viral ME/CFS reposted

New Cell paper from the team that discovered glymphatic clearance (how your brain removes waste during sleep). Sleep hours DIDN'T predict brain cleaning. Neither did REM or deep sleep. They found what actually matters - and why some sleeping pills might undermine it 🧵

DrDominicNg's tweet image. New Cell paper from the team that discovered glymphatic clearance (how your brain removes waste during sleep).

Sleep hours DIDN&apos;T predict brain cleaning. Neither did REM or deep sleep.

They found what actually matters - and why some sleeping pills might undermine it 🧵

Post Viral ME/CFS reposted

1) 🇸🇪 A Swedish study of 111 ME/CFS patients found reduced levels of vasopressin, a hormone that regulates water retention. Low vasopressin could lead to low blood volume and some of the orthostatic symptoms that ME/CFS patients report.

mecfsskeptic's tweet image. 1) 🇸🇪 A Swedish study of 111 ME/CFS patients found reduced levels of vasopressin, a hormone that regulates water retention. 

Low vasopressin could lead to low blood volume and some of the orthostatic symptoms that ME/CFS patients report.

Post Viral ME/CFS reposted

NAD+ depletion is likely key in MECFS as well. Could this be the MECFS-Alzheimer's link? We know that many of the brain issues (functional, structural, and pathogenic) we see in MECFS are similar to that of Alzheimer's. Just supplementing NAD+ alone however is not enough.

Never get Alzheimer’s Disease: The NAD+ Breakthrough 1/9) This graph hints at a potential breakthrough in Alzheimer’s disease. It shows that NAD+, a key energy carrier in the brain, is depleted in Alzheimer’s—but preserved in cognitively healthy brains. Restoring it may not…

nicknorwitz's tweet image. Never get Alzheimer’s Disease: The NAD+ Breakthrough

1/9) This graph hints at a potential breakthrough in Alzheimer’s disease.

It shows that NAD+, a key energy carrier in the brain, is depleted in Alzheimer’s—but preserved in cognitively healthy brains.

Restoring it may not…


Post Viral ME/CFS reposted

San Diego researchers followed 172 low-income long COVID patients using Fitbit data. Those who stayed less active reported better sleep and improved social participation after 6 months compared to more active peers. formative.jmir.org/2025/1/e77644


Post Viral ME/CFS reposted

🧵 1/10 We are excited to share our preprint examining pre-pandemic POTS and Long COVID, using deep analysis of the insoluble microclot fraction of blood. Our study shows that the key pathology lies not in protein levels, but in post-translational modifications (PTMs) hidden…


Post Viral ME/CFS reposted

Lactoferrin - the natural antiviral that blocks 90% of COVID spike protein fusion Viruses (COVID, flu, RSV) infect by fusing their spike proteins with your cell membranes - once inside, they REPLICATE Lactoferrin is one of the few compounds that directly binds viral spike…

FarvingCo's tweet image. Lactoferrin - the natural antiviral that blocks 90% of COVID spike protein fusion

Viruses (COVID, flu, RSV) infect by fusing their spike proteins with your cell membranes - once inside, they REPLICATE

Lactoferrin is one of the few compounds that directly binds viral spike…

Post Viral ME/CFS reposted

IFL Science: What Causes All The Symptoms Of Long COVID And ME/CFS? The Brainstem Could Be The Key A new theory has been put forward, suggesting that damage to this vital part of the brain could explain why these conditions affect so many bodily systems' iflscience.com/what-causes-al…


Post Viral ME/CFS reposted

🔴🚩What you’re describing fits remarkably well with what we outline in our recent review. Across narcolepsy, ME/CFS, Long COVID and other autoimmune conditions, the common denominator is not the specific trigger, but the genetic substrate: ancestral HLA-II haplotypes,…

1) This year, there were reports of 7 autopsies of ME/CFS patients, showing a dramatic reduction in CRH-producing neurons. This info was shared at the IACFS/ME conference, but the results still haven’t been published yet. Similar findings have been found in type 1 narcolepsy.

mecfsskeptic's tweet image. 1) This year, there were reports of 7 autopsies of ME/CFS patients, showing a dramatic reduction in CRH-producing neurons. This info was shared at the IACFS/ME conference, but the results still haven’t been published yet.

Similar findings have been found in type 1 narcolepsy.


Post Viral ME/CFS reposted

1) We’ve just published our review of the most interesting ME/CFS studies of 2025. It feels like this year, we’ve made a significant step towards understanding the pathophysiology of ME/CFS. A brief overview of the studies that caught our eye 👇

mecfsskeptic's tweet image. 1) We’ve just published our review of the most interesting ME/CFS studies of 2025.

It feels like this year, we’ve made a significant step towards understanding the pathophysiology of ME/CFS.

A brief overview of the studies that caught our eye 👇

Post Viral ME/CFS reposted

A big thank you to everyone who did anything, big or small, for the Myalgic Encephalomyelitis / Chronic Fatigue Syndrome +/or Long Covid cause in 2025 (including simply sharing messages on social media). 👏 Together we can make a difference. 👍 #MEcfs #LongCovid

TomKindlon's tweet image. A big thank you to everyone who did anything, big or small, for the Myalgic Encephalomyelitis / Chronic Fatigue Syndrome +/or Long Covid cause in 2025 (including simply sharing messages on social media). 👏

Together we can make a difference. 👍

#MEcfs #LongCovid

Post Viral ME/CFS reposted

Researchers in a recent #ScienceReview examine the influence that biological sex exerts on the immune system and immune-related diseases. Learn more: scim.ag/47LTwya

ScienceMagazine's tweet image. Researchers in a recent #ScienceReview examine the influence that biological sex exerts on the immune system and immune-related diseases. 

Learn more: scim.ag/47LTwya

Post Viral ME/CFS reposted

ME/CFS is now an objectively identifiable disease, moving past the "psychosomatic" era. Several new diagnostic technologies, including EpiSwitch and Nanoneedle, show high accuracy (90-96%), with AI being key to their success and commercialization. drive.google.com/file/d/1DEDBSh…

dlingenfelter's tweet image. ME/CFS is now an objectively identifiable disease, moving past the &quot;psychosomatic&quot; era.

Several new diagnostic technologies, including EpiSwitch and Nanoneedle, show high accuracy (90-96%), with AI being key to their success and commercialization.
drive.google.com/file/d/1DEDBSh…
dlingenfelter's tweet image. ME/CFS is now an objectively identifiable disease, moving past the &quot;psychosomatic&quot; era.

Several new diagnostic technologies, including EpiSwitch and Nanoneedle, show high accuracy (90-96%), with AI being key to their success and commercialization.
drive.google.com/file/d/1DEDBSh…

Post Viral ME/CFS reposted

1) This year, there were reports of 7 autopsies of ME/CFS patients, showing a dramatic reduction in CRH-producing neurons. This info was shared at the IACFS/ME conference, but the results still haven’t been published yet. Similar findings have been found in type 1 narcolepsy.

mecfsskeptic's tweet image. 1) This year, there were reports of 7 autopsies of ME/CFS patients, showing a dramatic reduction in CRH-producing neurons. This info was shared at the IACFS/ME conference, but the results still haven’t been published yet.

Similar findings have been found in type 1 narcolepsy.

Post Viral ME/CFS reposted

A recent study showed a 33% improvement in TINNITUS with a mix of common / cheap supplements. Over 3 months, taking: ⊙ 5-HTP ⊙ Ginkgo biloba ⊙ Magnesium ⊙ Melatonin ⊙ Vitamin B5 ⊙ B6 ⊙ Zinc These nutrients help support the key pathways that are dysregulated in…

Outdoctrination's tweet image. A recent study showed a 33% improvement in TINNITUS with a mix of common / cheap supplements.

Over 3 months, taking:

⊙ 5-HTP
⊙ Ginkgo biloba
⊙ Magnesium 
⊙ Melatonin 
⊙ Vitamin B5
⊙ B6 
⊙ Zinc

These nutrients help support the key pathways that are dysregulated in…

Ringing in your ears? Read this. This is all about TINNITUS - how it happens, and what you might be able to do about it:

Outdoctrination's tweet image. Ringing in your ears? Read this.

This is all about TINNITUS - how it happens, and what you might be able to do about it:


Post Viral ME/CFS reposted

Great thread re: HSV causing dementia & how what’s seen in Alzheimer’s brains is the body trying to fight back against infection. For more on this, see part 2 of my Monolaurin series in ZeroSpin, where I review tons of data on this topic. open.substack.com/pub/zerospin/p…

1/ This important new study found that herpes simplex #virus 1 infection can drive the formation of tau tangle aggregates - protein clumps that facilitate the death of neurons in the #Alzheimer’s brain: nature.com/articles/s4159…

microbeminded2's tweet image. 1/ This important new study found that herpes simplex #virus 1 infection can drive the formation of tau tangle aggregates - protein clumps that facilitate the death of neurons in the #Alzheimer’s brain:
nature.com/articles/s4159…


Post Viral ME/CFS reposted

Glymphatic dysfunction—a failure in the brain's waste-clearance system—is a root cause of ME/CFS symptoms like brain fog and PEM. Future therapies should focus on improving glymphatic function by targeting sleep quality or AQP4 channels. pubmed.ncbi.nlm.nih.gov/41373677/

dlingenfelter's tweet image. Glymphatic dysfunction—a failure in the brain&apos;s waste-clearance system—is a root cause of ME/CFS symptoms like brain fog and PEM.

Future therapies should focus on improving glymphatic function by targeting sleep quality or AQP4 channels.
pubmed.ncbi.nlm.nih.gov/41373677/
dlingenfelter's tweet image. Glymphatic dysfunction—a failure in the brain&apos;s waste-clearance system—is a root cause of ME/CFS symptoms like brain fog and PEM.

Future therapies should focus on improving glymphatic function by targeting sleep quality or AQP4 channels.
pubmed.ncbi.nlm.nih.gov/41373677/

Post Viral ME/CFS reposted

Translation: “Interesting small 3D muscle study: Serum from ME/CFS and Long-COVID patients disrupt muscle contraction, mitochondrial function, and calcium balance. Further indication of a serum factor and a regulatory muscle dysfunction.”

Interessante kleine 3D-Muskelstudie: Seren von ME/CFS- und Long-COVID-Patienten stören Muskelkontraktion, Mitochondrienfunktion und Calciumhaushalt. Weiterer Hinweis auf einen Serumfaktor und eine regulatorische Muskeldysfunktion. iopscience.iop.org/article/10.108…



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