Post Viral ME/CFS

According to ME/CFS Science, the "most interesting ME/CFS research studies" of 2025 included work from Chris Ponting, Rob Wüst, Bupesh Prusty, Nuno Sepúlveda, and Carmen Schiebenbogen, all of whom have received funding from ME Research UK. Read more: bit.ly/49mIlev

This is MASSIVE A breakthrough that could redefine chronic pain treatment in 2026. Scientists have uncovered a biological mechanism that may finally offer real relief for chronic nerve pain by restoring the tiny powerhouses inside our cells. Researchers just discovered that…

Work on lowering "whole body pathogen load". We get so hung up on testing and if decent (read: expensive) testing cannot be accessed we put off treating. Herbal treatments are among the cheapest and most accessible around. They are also generally - highly general and…

Lab-grown mini muscles showed that blood from people with chronic fatigue syndrome (ME/CFS) and Long COVID can directly weaken and damage muscle cells. The muscles first tried to adapt their energy use, then became fragile and lost strength.

Thanks to everyone for the interest in the work we are doing using combination antivirals #LongCOVID. As I mentioned, this first case series publication is a beginning, not an end - there is much more work to be done. To that end, we're pleased to globenewswire.com/news-release/2… 1/

In chronic illness "stress" is not a 'state of mind' its a state of PHYSIOLOGY. Stress in chronic illness is not a "thinking" thing - its a "physical function" thing.

New research finds people with ME/CFS have a striking deficiency in vasopressin - a hormone that helps the body retain water. This could explain common symptoms like constant thirst and dizziness upon standing. Let's break down the findings.

⚠️‼️I think some of its framing leads to conceptual oversimplifications that are worth clarifying. The review proposes a “third state” of herpesvirus infection termed abortive lytic replication, where early lytic genes are expressed without completion of full viral replication.…

1) This hypothesis paper argues that herpesviruses aren't either active (lytic replication) or passive (latency) but that there's a third state called 'abortive lytic replication' where the virus is active but doesn't replicate itself. They suspect this plays a role in ME/CFS.

The gut<->brain axis impact on health and disease is far more important than anticipated, as reflected by GLP-1 effects, modulating the immune system, direct neural circuits, the microbiome, and more. A stellar new, open-access review @jclinicalinvest @ZachLorschMDPhD…

Great win early in the year to receive notification that our case series looking into Dr Pridgen’s Valacyclovir, Celecoxib and Paxlovid protocol seems to really help some folks with #LongCOVID. This paper is a start, not the be-all and end-all: frontiersin.org/journals/immun… 1/

I thought I would repost this to highlight again some of the many varied symptoms that can be found in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Particularly relevant when similarities with the #LongCovid presentation in some people are being missed #MEcfs 1/

New Cell paper from the team that discovered glymphatic clearance (how your brain removes waste during sleep). Sleep hours DIDN'T predict brain cleaning. Neither did REM or deep sleep. They found what actually matters - and why some sleeping pills might undermine it 🧵

1) 🇸🇪 A Swedish study of 111 ME/CFS patients found reduced levels of vasopressin, a hormone that regulates water retention. Low vasopressin could lead to low blood volume and some of the orthostatic symptoms that ME/CFS patients report.

NAD+ depletion is likely key in MECFS as well. Could this be the MECFS-Alzheimer's link? We know that many of the brain issues (functional, structural, and pathogenic) we see in MECFS are similar to that of Alzheimer's. Just supplementing NAD+ alone however is not enough.

San Diego researchers followed 172 low-income long COVID patients using Fitbit data. Those who stayed less active reported better sleep and improved social participation after 6 months compared to more active peers. formative.jmir.org/2025/1/e77644

🧵 1/10 We are excited to share our preprint examining pre-pandemic POTS and Long COVID, using deep analysis of the insoluble microclot fraction of blood. Our study shows that the key pathology lies not in protein levels, but in post-translational modifications (PTMs) hidden…

Lactoferrin - the natural antiviral that blocks 90% of COVID spike protein fusion Viruses (COVID, flu, RSV) infect by fusing their spike proteins with your cell membranes - once inside, they REPLICATE Lactoferrin is one of the few compounds that directly binds viral spike…

IFL Science: What Causes All The Symptoms Of Long COVID And ME/CFS? The Brainstem Could Be The Key A new theory has been put forward, suggesting that damage to this vital part of the brain could explain why these conditions affect so many bodily systems' iflscience.com/what-causes-al…

🔴🚩What you’re describing fits remarkably well with what we outline in our recent review. Across narcolepsy, ME/CFS, Long COVID and other autoimmune conditions, the common denominator is not the specific trigger, but the genetic substrate: ancestral HLA-II haplotypes,…