Post Viral ME/CFS

The gut<->brain axis impact on health and disease is far more important than anticipated, as reflected by GLP-1 effects, modulating the immune system, direct neural circuits, the microbiome, and more. A stellar new, open-access review @jclinicalinvest @ZachLorschMDPhD…

Great win early in the year to receive notification that our case series looking into Dr Pridgen’s Valacyclovir, Celecoxib and Paxlovid protocol seems to really help some folks with #LongCOVID. This paper is a start, not the be-all and end-all: frontiersin.org/journals/immun… 1/

I thought I would repost this to highlight again some of the many varied symptoms that can be found in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Particularly relevant when similarities with the #LongCovid presentation in some people are being missed #MEcfs 1/

New Cell paper from the team that discovered glymphatic clearance (how your brain removes waste during sleep). Sleep hours DIDN'T predict brain cleaning. Neither did REM or deep sleep. They found what actually matters - and why some sleeping pills might undermine it 🧵

1) 🇸🇪 A Swedish study of 111 ME/CFS patients found reduced levels of vasopressin, a hormone that regulates water retention. Low vasopressin could lead to low blood volume and some of the orthostatic symptoms that ME/CFS patients report.

NAD+ depletion is likely key in MECFS as well. Could this be the MECFS-Alzheimer's link? We know that many of the brain issues (functional, structural, and pathogenic) we see in MECFS are similar to that of Alzheimer's. Just supplementing NAD+ alone however is not enough.

San Diego researchers followed 172 low-income long COVID patients using Fitbit data. Those who stayed less active reported better sleep and improved social participation after 6 months compared to more active peers. formative.jmir.org/2025/1/e77644

🧵 1/10 We are excited to share our preprint examining pre-pandemic POTS and Long COVID, using deep analysis of the insoluble microclot fraction of blood. Our study shows that the key pathology lies not in protein levels, but in post-translational modifications (PTMs) hidden…

Lactoferrin - the natural antiviral that blocks 90% of COVID spike protein fusion Viruses (COVID, flu, RSV) infect by fusing their spike proteins with your cell membranes - once inside, they REPLICATE Lactoferrin is one of the few compounds that directly binds viral spike…

IFL Science: What Causes All The Symptoms Of Long COVID And ME/CFS? The Brainstem Could Be The Key A new theory has been put forward, suggesting that damage to this vital part of the brain could explain why these conditions affect so many bodily systems' iflscience.com/what-causes-al…

🔴🚩What you’re describing fits remarkably well with what we outline in our recent review. Across narcolepsy, ME/CFS, Long COVID and other autoimmune conditions, the common denominator is not the specific trigger, but the genetic substrate: ancestral HLA-II haplotypes,…

1) We’ve just published our review of the most interesting ME/CFS studies of 2025. It feels like this year, we’ve made a significant step towards understanding the pathophysiology of ME/CFS. A brief overview of the studies that caught our eye 👇

A big thank you to everyone who did anything, big or small, for the Myalgic Encephalomyelitis / Chronic Fatigue Syndrome +/or Long Covid cause in 2025 (including simply sharing messages on social media). 👏 Together we can make a difference. 👍 #MEcfs #LongCovid

Researchers in a recent #ScienceReview examine the influence that biological sex exerts on the immune system and immune-related diseases. Learn more: scim.ag/47LTwya

ME/CFS is now an objectively identifiable disease, moving past the "psychosomatic" era. Several new diagnostic technologies, including EpiSwitch and Nanoneedle, show high accuracy (90-96%), with AI being key to their success and commercialization. drive.google.com/file/d/1DEDBSh…

1) This year, there were reports of 7 autopsies of ME/CFS patients, showing a dramatic reduction in CRH-producing neurons. This info was shared at the IACFS/ME conference, but the results still haven’t been published yet. Similar findings have been found in type 1 narcolepsy.

A recent study showed a 33% improvement in TINNITUS with a mix of common / cheap supplements. Over 3 months, taking: ⊙ 5-HTP ⊙ Ginkgo biloba ⊙ Magnesium ⊙ Melatonin ⊙ Vitamin B5 ⊙ B6 ⊙ Zinc These nutrients help support the key pathways that are dysregulated in…

Great thread re: HSV causing dementia & how what’s seen in Alzheimer’s brains is the body trying to fight back against infection. For more on this, see part 2 of my Monolaurin series in ZeroSpin, where I review tons of data on this topic. open.substack.com/pub/zerospin/p…

Glymphatic dysfunction—a failure in the brain's waste-clearance system—is a root cause of ME/CFS symptoms like brain fog and PEM. Future therapies should focus on improving glymphatic function by targeting sleep quality or AQP4 channels. pubmed.ncbi.nlm.nih.gov/41373677/

Translation: “Interesting small 3D muscle study: Serum from ME/CFS and Long-COVID patients disrupt muscle contraction, mitochondrial function, and calcium balance. Further indication of a serum factor and a regulatory muscle dysfunction.”