sev
@SevLechner
Postdoc in Winter lab, CeMM. Rewiring transcription factors — chemical proteomics — target deconvolution — drug discovery
Proteome-wide measurements of dose–response curves for 144 drugs reveal drug mechanisms of action go.nature.com/4a9lMs8 rdcu.be/egMl1
nature.com
Decrypting the molecular basis of cellular drug phenotypes by dose-resolved expression proteomics
Nature Biotechnology - Proteome-wide measurements of dose–response curves for 144 drugs reveal drug mechanisms of action.
🏆 Congrats to @georg_e_winter for receiving an @ERC_Research Consolidator Grant for GE|NEomorph, a project reprogramming cancer cells via transcription factors. It opens new avenues for targeted therapies in the fight against #cancer #ERCCoG ➡️ Read more: bit.ly/41h3AMG
Finally! It is happening! After 6 years of hard work by formidable teams in 13 institutions @RESOLUTE_IMI, we have ordered and validated the results and are able to share the FOUR (4) papers aimed at assigning functional properties to each human SLC #membranetransporter
You have a strong background in bioinformatics🖥️, data science📈, machine learning, and multi omics? You want to do a PhD👩🎓facilitating non-clinical safety assessment? If so, come and join our ProteomicsDB team. mls.ls.tum.de/compms/job-off…
Proud to see our 'detective story' on uncovering the MoA of Orpinolide published in its final form in @nchembio! Immensely grateful to @georg_e_winter, the Waldmann lab @mpimoph and @laraialab for being part of this fantastic collaboration!
Decrypting the molecular basis of cellular drug phenotypes by dose-resolved expression proteomics go.nature.com/4a9lMs8
We are happy to announce that decryptE is out, another step towards better understanding of drug MoAs. 🎉After elucidating the target space of drugs and how they dose-dependently alter PTMs in cells (decryptM),... (1/4)
...and another new Preprint coming right on its heels! This time by Jakob Trendel and colleagues. doi.org/10.1101/2024.0…
🔬 Research teams led by @georg_e_winter (CeMM) & @alessiociulli (University of Dundee) have found a new system that triggers cellular waste disposal. Published in @Nature, the findings shed light on mechanisms & therapeutic opportunities of this system ➡️ bit.ly/3Pejn8b
Are you a final year international PhD student or PDRA considering opportunities in Chemical Biology in London? Please contact me - the EDV group is on the look for prospective candidates for a Newton Fellowship application to tackle protein phosphatases edv-lab.com/join-us/
Me referring to a 'recent paper' in my writing and realise that 2017 was in fact 6 years ago
Telos, as they say. Love the consideration of HDAC6 in cardiovascular disease. This deal brings me back to postdoc days in Schreiberia. Cut my teeth as a chemical biologist on HDAC6 with @SchreiberStuart, learning so much from @mazit. Degraders of HDAC6 could be even more…
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