Tewhey Lab
@TewheyLab
Identifying the precise genetic mechanisms influencing human complex traits and disease risk at the @JacksonLab 🧬🐭💻✨ (tweets from students and post docs)
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I know you thought it was just another Thursday but SURPRISE! The Tewhey Lab is officially on Twitter!!! 🥳 Watch this space for science, lab and other fun updates from @r_tewhey's lab ⬇️
@MaineCalling's Patty Wight spoke with JAX researcher Ryan Tewhey (@TewheyLab) regarding his recent publication in @Nature. 📻 Listen to the coverage: mainepublic.org/health/2024-10… 💡 The study, published with the @BroadInstitute of MIT and Harvard, and @Yale University, showcases…
Excited to share our sequence design work published in @Nature. I had the privilege of co-leading this effort alongside my friend and colleague @SagerGosai under the supervision of @r_tewhey, @ReillyLikesIt, and @PardisSabeti nature.com/articles/s4158… 1/7
I’m thrilled to share that our paper “Machine-guided design of cell-type-targeting cis-regulatory elements” was published online in @Nature. nature.com/articles/s4158… #genomics #MachineLearning #SyntheticBiology #bioengineering 1/9
Using #AI, a Broad/@jacksonlab /@YaleMed team has developed a way to decipher the language of genetic switches that turn genes on and off, and designed new, synthetic switches that control genes' expression in specific cell types. broad.io/CRE-AI @ReillyLikesIt
Happy National Postdoc Appreciation Week to Tewhey Lab post-doc @takeshi_iwasaki!! 🥳🎉 Takeshi is studying regulatory variants in autoimmune disease and is actually this year’s @jacksonlab JAX scholar!!🏆🧬 #NPAW2024
Yes Takeshi!!!! JAX Scholar and Tewhey Lab post doc @takeshi_iwasaki talks about his work in the lab ⬇️🧬
2024 JAX Scholar @takeshi_iwasaki discusses his work in the @TewheyLab identifying #genomicvariants and genetic mechanisms that influence #autoimmunedisease, and the importance of linking genetic variants to disease presentation or risk: bit.ly/3XGRDhi
youtube.com
YouTube
What genetic variants influence autoimmune diseases? | 2024 JAX...
2024 JAX Scholar @takeshi_iwasaki discusses his work in the @TewheyLab identifying #genomicvariants and genetic mechanisms that influence #autoimmunedisease, and the importance of linking genetic variants to disease presentation or risk: bit.ly/3XGRDhi
youtube.com
YouTube
What genetic variants influence autoimmune diseases? | 2024 JAX...
Could not be more delighted to present our work investigating how over 220,000 complex and molecular trait-associated genetic variants affect transcriptional regulation using massively parallel reporter assays! biorxiv.org/content/10.110… See below for a 🧵. 1/n
#Postdoc job of the week: Join the @r_tewhey @TewheyLab to use novel, high-throughput techniques to study genetic mechanisms underlying complex traits, & the impact genetic variation has on gene regulatory function: …cksonlaboratory.wd1.myworkdayjobs.com/en-US/External… #postdocs #postdocjobs
This is by far the most convincing regulatory DNA synthetic design paper to date. Congrats to the authors 1/
I’m excited to share some work I co-lead with @i_rodcast and spanned the labs of @PardisSabeti, @ReillyLikesIt, and @r_tewhey to design and validate synthetic cis-regulatory elements with cell type-specific activity. biorxiv.org/content/10.110… 1/n
SO happy this is live! See @SagerGosai tweet explaining our amazing collab with @i_rodcast, @r_tewhey, @PardisSabeti! TLDR: Used AI to learn to 'read' the genome's regulatory code and 'write' new, synthetic functions. Evolution didn't create this neuronal enhancer, but it works!
I’m excited to share some work I co-lead with @i_rodcast and spanned the labs of @PardisSabeti, @ReillyLikesIt, and @r_tewhey to design and validate synthetic cis-regulatory elements with cell type-specific activity. biorxiv.org/content/10.110… 1/n
Thank you!!! Honored to be a Tufts GSBS Rosenberg Fellow 🥳 Grateful for the nomination from my program and the endless support from my PI and lab ☺️ @r_tewhey @TewheyLab
I’m excited to share some work I co-lead with @i_rodcast and spanned the labs of @PardisSabeti, @ReillyLikesIt, and @r_tewhey to design and validate synthetic cis-regulatory elements with cell type-specific activity. biorxiv.org/content/10.110… 1/n
I’m excited to share some work I co-lead with @i_rodcast and spanned the labs of @PardisSabeti, @ReillyLikesIt, and @r_tewhey to design and validate synthetic cis-regulatory elements with cell type-specific activity. biorxiv.org/content/10.110… 1/n
It’s official, the Twitter bio has been changed - ya girl’s a PhD candidate! 🥳 Grateful for all the support from my friends, family and committee! Super relieved to be done and even more ready for some of that Maine summer!! ☀️(Note: loading bar is not to scale…at all…)
New in @ScienceMagazine, JAX's @r_tewhey @TewheyLab & colleagues I.D. 800 human-specific conserved deletions (hCONDELS) that confer significant differences in regulatory activity, highlighting several with putative effects on brain development: jax.org/news-and-insig…
New in @ScienceMagazine, JAX's @r_tewhey @TewheyLab & colleagues I.D. 800 human-specific conserved deletions (hCONDELS) that confer significant differences in regulatory activity, highlighting several with putative effects on brain development: jax.org/news-and-insig…
Getting emotional about friendship and an ice bucket on a Thursday. 🥲🧊
the ice bucket, from corning, is truly an ELITE ice bucket. It's the Rolls Royce of ice buckets. The kind you get an unhealthy obsession with during your post doc, and won't buy for your own lab. Until your amazing friend buys one for you :)
#Postdoc job of the week: Join the @r_tewhey @TewheyLab to use novel, high-throughput techniques to study genetic mechanisms underlying complex traits, & the impact genetic variation has on gene regulatory function: …cksonlaboratory.wd1.myworkdayjobs.com/en-US/External… #postdocs #postdocjobs #sciencetwitter
Congratulations!! Kousuke's talk at @IMGC2023_sec was based on his paper on genetic variants of regulatory elements in autoimmune disease. Read Kousuke's BACH2 paper here: nature.com/articles/s4158…
nature.com
Prioritization of autoimmune disease-associated genetic variants that perturb regulatory element...
Nature Genetics - Integrating methods that assess allele-specific regulatory activity and chromatin accessibility in T cells identifies putative causal variants for five autoimmune diseases.
Thank you so much @IMGC2023_sec for selecting my talk as an outstanding presentation. It is a great honor!
![Dumont_Lab's profile picture. [Ran by: Laura Blanco-Berdugo]
The Dumont lab focus on the mechanisms that generate genetic diversity through the lens of evolution.](https://pbs.twimg.com/profile_images/1529162226447294464/LrdHUvyk.jpg)
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