Christopher W. Uhde, Ph.D.
@UhdeChristopher
Biotech equity analyst. Experimental systems biology PhD from Karolinska Institutet, postdoc in psychotropic drug discovery. Opinions expressed are my own
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You can really see the hole in the ozone layer
This is the number of satellites currently orbiting the Earth right now. ABSOLUTELY TERRIFYING 🤯
O, the irony of #pizzagate
Trump’s secretary of commerce, Howard Lutnick, said recently in an interview that a 2005 visit to Jeffrey Epstein’s home left him so revolted that he cut ties with Epstein. Emails released today tell a different story, showing Lutnick remained in contact for years afterward,…
It's amazing that AstraZeneca was able to get UK Prime Minister @Keir_Starmer to provide a quote of support in this press release announcing $15B of investments in China given how many life sciences jobs the UK has lost in the last year. astrazeneca.com/media-centre/p…
I wrote something for Politico about the real issue with Greg Bovino's overcoat. IMO, it isn't about whether the overcoat is tied to any particular regime, but about how immigration enforcement has become increasingly warlike in terms of strategy, discourse, and dress. 🧵
Gotta say, the hoodie-for-NYE-party look gets the thumb down from me
Ranking Freedom | The right-wing claim that Europe has become dictatorial is nonsense, according to rankings of economic, political, and press freedom, including the rankings by right-wing think tanks. By Dan Gardner @dgardner open.substack.com/pub/dgardner/p…
Food for thought
What does it take to achieve the highest level of human performance? Across athletics, science, chess, and music @ScienceMagazine science.org/doi/10.1126/sc…
😆
Maerten Soolmans, son of a wealthy Dutch merchant, in 1634. Someone in his social position today would likely wear a golf polo and dress sneakers.
Important #vaccines perspective
Dismantling of U.S. childhood vaccination schedule has begun | STAT statnews.com/2025/12/08/aci…
Thought-provoking, and in fairly urgent need of study: anyone interested in the truth rather than ideology should want to know if it is essentially a cry for help in unconventional quarters.
"Why do so many girls in Blackpool want to become boys?" ✍️ @bindelj My friend Julie Bindel on the connection between sexual trauma and the wish to escape a female body. juliebindel.substack.com/p/why-do-so-ma…
The nice thing is it should make it a lot easier to spot statistical outliers
This is a pretty crazy visualization of SAT results by parents’ income
Hard to believe RFK and Makary can last that much longer in their roles… I would have thought Trump would be less closely wedded to these guys on the issue of healthcare than to other partners (I’ve always felt he is using them to get revenge for COVID vaccine timing)
I read the Prasad letter, and in my view this is Gottlieb is mischaracterising what Prasad wrote.
@damiangarde It's interesting that this FDA seems concerned about the opinions of clients of investment banks. I wonder if Piper Sandler has invited Scott Gottlieb to give his perspective. This is what Gottlieb said on CNBC today about the potential impact of Prasad & Makary's…
youtube.com
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Dr. Gottlieb: FDA is systemically trying to dismantle components of...
That’s my read as well. The shift from two to one has been long in the making, but it’s a big shift that is going to give a lot of ammo to industry to fight against FDA requesting additional data.
AgencyIQ did an analysis of this question back in February. What we found: - CDER already approved majority of NMEs using a single study - Percentage of single trials stable in recent years but above historical average - Some offices use authority more. agencyiq.com/blog/analysis-…
The FDA plans to begin requiring one clinical study, instead of the standard two, for medical products before consideration for approval. trib.al/q7xVmZu
Strong words from the senator who cast the tie-breaking vote to let RFK take over HHS and dismantle ACIP
Aaron Siri is a trial attorney who makes his living suing vaccine manufacturers. He is presenting as if an expert on childhood vaccines. The ACIP is totally discredited. They are not protecting children. cdc.gov/acip/downloads…
While I like many aspects of the vision that Makary and Prasad offered, they (Makary most of all) clearly lack leadership ability. Where was the stakeholder engagement and consensus building? Obviously they tried to move way too fast.
Ever worked at a place where everyone left or was fired? FDA removes longtime over-the-counter drugs regulator from her position By the inimitable @LizzyLaw_ statnews.com/2025/12/03/the…
The pace of this FDA turnover/news cycle is totally out of control, especially for an agency that’s intentionally slow and boring
Hilarious this week from @TheEconomist - esp halfway down column 1 in the first pic and the first sentence of the second pic
Prasad is a prolific clinical researcher , a clinical practicing oncologist and an epidemiologist who quickly climbed the ladder of academia publishing papers about pharmaceutical industry gamesmanship and spoke about regulatory capture frequently. This made him very popular…
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