AskFredBrown
@askfredbrown
A truth-telling antigen, trying to stimulate the world’s immune system to respond more robustly to the threat.
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Five official Variants of Concern in US according to CDC classification: B.1.1.7, B.1.351, P.1, B.1.427, and B.1.429: cdc.gov/coronavirus/20…
This highlights the importance of developing robust, reproducible, replicable and interpretable ML methods in medical science .
More than 300 #machinelearning models for diagnosing #COVID19 were published in 2020. A new review has found that none of them are suitable for clinical use, due to biases, methodological flaws, and 'Frankenstein datasets': bit.ly/2NkHmWp @FacultyMaths #AI
Analysis of relaxation of COVID-19 control in UK. Suggests that even if vaccine reduces transmission substantially and coverage assumed to be reasonably high among adults (95% in age 80+, 85% in 50–79, 75% in 18–49), could still have R>1 in the absence of other control measures.
More than 300 #machinelearning models for diagnosing #COVID19 were published in 2020. A new review has found that none of them are suitable for clinical use, due to biases, methodological flaws, and 'Frankenstein datasets': bit.ly/2NkHmWp @FacultyMaths #AI
Useful Covid-19 source
As of 19.03.2021, we have indexed 146472 publications: *13232 pre-prints *133240 peer-reviewed publications Pre-prints: BioRxiv, MedRxiv Peer-reviewed: PubMed, EMBASE, PsycINFO zika.ispm.unibe.ch/assets/data/pu…
Fred's latest slide deck is up on the web - The Race Between Viral Variants & Human Vaccines - A presentation made to the Harvard Business School Community, March 14th, 2021 fredbrown.com/freds-decks/ @kakape @sciencecohen @evidencelive @eggersnsf @ASlavitt
Worth reading this thoughtful piece by @bencowling88 on possible pandemic futures for Hong Kong (including points that are relevant to many other places too): hkcnews.com/article/39405/…
This work is now peer reviewed and published @Eurosurveillanc. eurosurveillance.org/content/10.280…
New study on mortality of B.1.1.7 using health records from England. We found the variant of concern (VOC) was 1.67x more likely to result in death, controlling for comorbidities, age, week, region & other sociodemographics. NB NOT YET PEER REVIEWED (1/8) medrxiv.org/content/10.110…
Useful thread summarising key conclusions by the EMA and answers to press questions on AstraZeneca vaccine @kakape
"The committee also concluded that the vaccine is not associated with an increase in the overall risk of thrombo embolic events or blood clots”, says Cooke.
Takes 50 seconds to watch. Fiocruz data show ICU COVID-bed utilisation by Brazilian federative units, states and the Federal District. Between January and early March 2021 Brazil's health care system moves towards collapse. youtu.be/cJqpsTVYdms @fiocruz_en @NYTimesCohen
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Ocupação de leitos de UTI Covid-19
Just used @evidencelive to search for published and pre-print articles on recombination in context of Covid-19. [zika.ispm.unibe.ch/assets/data/pu…] Hoping to hear more on this topic at @RoySocMed webinar today: The pandemic year - what happens next?zoom.us/webinar/regist… @mugecevik
![askfredbrown's tweet image. Just used @evidencelive to search for published and pre-print articles on recombination in context of Covid-19. [zika.ispm.unibe.ch/assets/data/pu…] Hoping to hear more on this topic at @RoySocMed webinar today: The pandemic year - what happens next?zoom.us/webinar/regist… @mugecevik](https://pbs.twimg.com/media/EwwFSdiWEAANYJH.jpg)
Although the viral evolution of SARS-CoV-2 is slowed by the RNA proofreading capability of its replication machinery, a variant with a single-residue substitution (D614G) in its spike (S) protein rapidly became the dominant strain throughout the world @EricTopol @ScienceMagazine
Just published @ScienceMagazine In the first month of the pandemic the D614G strain became dominant. Now, thru structural biology & cryo-EM, we know how the G (glycine) substitution made the spike protein trimer more stable, and somewhat more infectious science.sciencemag.org/content/early/…
Gene stacking leads to covid19 variants of concern, with higher infectivity (stronger, longer transmission); neutralizing antibody resistance, and greater virulence through stronger binding. Raising threshold for herd immunity, reducing vaccine efficacy and increasing reinfection
Every defensive tool we use against Covid-19 drives genetic selection to overcome it, whether npis, vaccines or therapeutics
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