🔴🔴Our paper is out today in @CellCellPress! Since the preprint and thanks to the reviewers, we added a validation series of 10,000+ patients, an analysis of the timing of metastases & linked different analyses to further extended the hypotheses cell.com/cell/fulltext/…
Tks anirban ! RNA seq and whole exome in 1000 and 500 pretreated metastatic cancers. Interesting to see the impact of prior therapies, especially platinum, on DNA + discovery of new alterations involved in resistance (PTEN transloc). A huge work from PRISM (maybe futur center🤞)
Preprint from @ypradat @FAndreMD et al @PrismCenter @GustaveRoussy: Integrative pan-cancer genomic and transcriptomic analyses of refractory metastatic cancer medrxiv.org/content/10.110… Whole exome & transcriptome sequencing on >1,000 metastatic tumors including #PancreaticCancer
Featured today by @MSKLibrary: Outcomes and Molecular Features of Brain Metastasis in...dx.doi.org/10.1001/jamane… @bastien_nguyen @ahhanisha @JoanneF_Chou @VStrongMD @Daniela_Molena @ILSONDavid @CowzerDarren @nikolausschultz @md_kathryn @Dr_N_Moss @YJanjigianMD @SteveMaronMD
Our latest manuscript studying rectal cancer is out in @NatureMedicine. This is work led by @DrGarciaAguilar, @fsanchezvega and myself, in collaboration with amazing colleagues at @MSKCancerCenter. 1/n nature.com/articles/s4159…
PIK3R1-mutation regulates Insulin-PI3K-glycolytic pathway in #prostatecancer. Our @CCR_AACR paper shows frequent oncogenic alteration of PIK3R1 in #mCRPC @DrPhilKantoff @subhiii_n @nikolausschultz @PCF_Science @MSKCancerCenter @MountsinaiUro aacrjournals.org/clincancerres/…
new out in Nature, wonderful paper exploring the events in the first next cell cycle after whole genome duplication: nature.com/articles/s4158…
What a striking finding on questionable driver -- KRAS Q61K mutation. It seems like this is functional only when this coexists with adjacent silent mutation in G60 that abolishes cryptic splice site. Shocking deep biology from TKI resistance research. nature.com/articles/s4158…
Our new @NCIHTAN paper has been published! It presents a unique spatial atlas of linked multimodal datasets from serial biopsies of a metastatic breast cancer evolving across multiple courses of therapy. 1/6 cell.com/cell-reports-m…
cell.com
An omic and multidimensional spatial atlas from serial biopsies of an evolving metastatic breast...
Identifying mechanisms of response and resistance to treatment in individual cancer patients is challenging but critical for improvement of precision medicine outcomes. Johnson et al. report a...
@ASCO Provisional Clinical Opinion re Somatic Genomic Testing in pts w/ Metastatic or Adv Cancer is out! An honor to be on this boat captained by @MarkRobsonMD & Drs. Funda Meric-Bernstam w/ Dr. Amber Johnson. ascopubs.org/doi/full/10.12…
Online Now: Metastasis and organotropism: A look through the lens of large-scale clinical sequencing data dlvr.it/SJQ1K0
Read this week's Cancer Discovery #ResearchWatch Genomic Alterations Distinguish Patterns of Metastatic Dissemination by @nikolausschultz, @fsanchezvega, @bastien_nguyen, @CJFongPhD, @sloan_kettering. bit.ly/3oG7Ela
🚨 Breaking - Data from 25,000 patients is helping scientists at MSK's Sloan Kettering Institute answer — can a tumor's genetic mutations help predict whether and where cancer will spread? @CellPressNews @nikolausschultz @fsanchezvega @bastien_nguyen bit.ly/3uvXWFI
In a phase II study of the KIT inhibitor imatinib plus the MEK inhibitor binimetinib as first-line therapy for advanced-stage GIST, the ORR was 69%, mPFS was 29.9 months and mOS was not reached; toxicity was manageable: ascopubs.org/doi/full/10.12… #stcsm #scmsm #medonc #caxtx
KIT+ MEK inhibition in GIST ➡️Phase II Trial of Imatinib Plus Binimetinib in Patients With Treatment-Naive Advanced Gastrointestinal Stromal Tumor ⭐️The best ORR was 69.0% @WTapMD @JTrentMDPhD @JCO_ASCO ascopubs.org/doi/full/10.12…
Proud to share our work out today in @NatureGenet. With @srinipr4, @MFBerger1 and @BarryTaylorLab. nature.com/articles/s4158… We try to understand the extent to which cancers arising in patients with inherited pathogenic variants are actually mediated by the germline defect, 1/n
Black men die from prostate cancer twice as often as White men. @BrandonMahal, @FranklinHuang, @KOSJ12, and others have shown that tumors from Black men can be genomically different. Insights from Stopsack et al study out today @CCR_AACR. @PCFnews doi.org/10.1158/1078-0… 1/n
@OncoKB's @US_FDA tab is @FDAOncology recognized! A 3y journey & we couldn't be prouder to state we are the 1st somatic tumor mutation database w/ this accolade. @OncoKB is the combined dedicated effort to sustain a knowledge base powered by @sloankettering clinical expertise.
FDA granted recognition to a partial listing of the Memorial Sloan Kettering Cancer Center’s Oncology Knowledge Base (OncoKB) as the first tumor mutation database to be included in the Public Human Genetic Variant Databases. bit.ly/3oFVklT
Perhaps the best and most caring cancer genomics mentor in the world to work with 👇
We are looking for a postdoctoral researcher to join our highly collaborative cancer genomics group in @CompOncMSK @sloan_kettering. Analyze MSK-IMPACT clinical sequencing data, collaborate with @NCIgenomics GDAN, @NCIHTAN, @AACR Project GENIE, and others. componcmsk.org/careers/postdo…
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