What controls whether cells - or clusters of cells - break off from an invading cancerous front? New preprint from my group in collaboration with the Konstantopoulos group @KKLabJHU , led by @wwang721 doi.org/10.1101/2024.0…
This is a really fun project - we modeled experiments from @KKLabJHU doi.org/10.1126/sciadv… - trying to capture how rates and distributions of cluster size depend on the geometry of the channel they're invading into.
We find cell dissociation depends on cell-cell adhesion, noise in cell motility, the presence of leader cells, as well as some surprises -- like cell-channel adhesion.
For physicists, we also show that there's a big difference between "jammed" and "unjammed" tissues. We find unjamming is necessary - but not sufficient - to predict the ability of cells to dissociate from an invading front.
Much much more in the paper, so I won't drag on here. Congrats to @wwang721 !
I would love to be able to make a vector plot video like that! 😍
United States เทรนด์
- 1. FINALLY DID IT 590K posts
- 2. The JUP 352K posts
- 3. The PENGU 236K posts
- 4. Clinton 378K posts
- 5. #GoCanes 5,516 posts
- 6. Newcastle 85K posts
- 7. Garnacho 29.5K posts
- 8. #GMMTVStarlympics2025 8.26M posts
- 9. #Caturday 3,688 posts
- 10. Reece James 30K posts
- 11. Good Saturday 33.5K posts
- 12. Vivek 54.1K posts
- 13. #SaturdayVibes 4,694 posts
- 14. Biff 3,650 posts
- 15. Arlovski N/A
- 16. GAME DAY 26.3K posts
- 17. Chelsea 163K posts
- 18. #outstanding 3,479 posts
- 19. Jack Doherty 1,208 posts
- 20. Texas A&M 14.4K posts
Something went wrong.
Something went wrong.