Jacob Kimmel
@jacobkimmel
Co-founder & President @NewLimit | Prev: PI @Calico, PhD @UCSF | Interested in aging, machine learning, genomics, the technology production function
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why don’t we have more medicines? inventing medicines has grown less efficient, limited by our knowledge of biological targets for the 1st time, AI & genomics have the potential to make this knowledge abundant – one of the largest potential impacts of the intelligence age.
i'd like to think that Akio Morita would be happy with the view from our new FACS machine the best ideas tend to emerge in beautiful places
through the late summer @newlimit, we've been upgrading our 1st prototype medicines to prepare for human trials highlights - +2 prototype medicines with efficacy in liver disease models - +14 TF payloads that restore function in old T cells - +4000 TF sets tested across…
it's hard to imagine a better on ramp to the industry than working with the team @SusaVentures. highly recommended.
Want to be a VC, angel or future founder? Alumni are now at a16z, Susa, South Park Commons, conviction, cantos and more. Some co-founded unicorn companies like Nourish. The program works. 2 extra days to apply.
"A good way to understand a lot of evolution—and how you're able adapt to new environments or pathogens—is that gene duplication is possible. The real problem is this: if one or two mutations break the gene, and only three mutations together fixes it again, it’s very hard for…
.@jacobkimmel thinks he can find the transcription factors necessary to reverse aging. 0:00:00 – Three reasons evolution didn't optimize for longevity 0:12:48 – Why didn't humans evolve their own antibiotics? 0:26:08 – De-aging cells via epigenetic reprogramming 0:45:24 – Viral…
.@jasonjoyride is among the best emerging storytellers in science & technology excited to see him making the life sciences more legible
We got 3 answers from 3 scientists! 1. Healthy years / $ 2. Experiments / time 3. Accuracy of aging clock Find out why in our first ever "lighthouse" video!
.@dwarkesh_sp has a rare talent for traversing the tree of ideas by stepping upon only the most entropic branches it was a joy to discuss ideas around AI in bio, human evolution, the biology of aging, @newlimit, & the future of therapeutics a few weeks back
.@jacobkimmel thinks he can find the transcription factors necessary to reverse aging. 0:00:00 – Three reasons evolution didn't optimize for longevity 0:12:48 – Why didn't humans evolve their own antibiotics? 0:26:08 – De-aging cells via epigenetic reprogramming 0:45:24 – Viral…
improving biology that evolution has optimized is absurdly difficult. one reason for optimism in longevity is that evolution hardly selected for it. even simple interventions can restore function or extend life. it seems likely that medicines turning on just a few key genes can…
.@jacobkimmel thinks that the functionality to reverse aging already exists in our epigenome. But then why didn't evolution already optimize for longevity? Jacob explains that if you consider evolution as an optimizer, the gradients flow in a really surprising way. Naively,…
today @newlimit, our robot fleet mixed up the latest batch of reprogramming prototypes for downstream functional testing soon, we'll need to run a few in parallel
it's clear within a few minutes of meeting that @ramtinnaimi is a force of nature loved this conversation & feel privileged to work with the @abstractvc team @newlimit
I’m always amazed how few investors can explain the specific thing they can do better than others. When I first asked Ramtin (@ramtinnaimi) this question, he gave one of the most specific answers I’ve heard (about how he helps founders end up owning more of their company, along…
great overview of @_DimensionCap portco @newlimit, pioneering tech in epigenetic reprogramming to ̶s̶l̶o̶w̶ reverse aging in pursuit of future life saving, life extending, medicines
Our new @corememory video on @newlimit, which is finding combinations of proteins that reverse aging across the body. It is perhaps the most exciting work in the bio-tech field. Backed by @brian_armstrong @patrickc @collision @JoshuaKushner @natfriedman and others
ashlee & the @corememory team are among the best storytellers in science. we were privileged to host them for a look inside @newlimit. we hope this is only the first of many windows into our mission to add healthy years to each life.
Our new @corememory video on @newlimit, which is finding combinations of proteins that reverse aging across the body. It is perhaps the most exciting work in the bio-tech field. Backed by @brian_armstrong @patrickc @collision @JoshuaKushner @natfriedman and others
NewLimit paper just dropped @icmlconf showing our SOTA AI models can predict perturbed cell states. Helps to have the largest primary cell perturbation dataset in the world. Bonus points for one of the first demonstration of active learning in bio.
![LinaZNilsson's profile picture. MedTech. Open Science & Makers. [Data Science Product at machine learning startup @RecursionPharma]](https://pbs.twimg.com/profile_images/1182676462303727616/qoOAa42C.jpg)
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