Joanna C Lima
@joannaclima
Post-doc at @Ludwig_Cancer @OxfordUni. from Brazil 🇧🇷 helping Brazilian students to get scholarships to study abroad CEO: @apliquenoalvo 🚀 🎯
Może Ci się spodobać
This work was done together with my 🍅 squad teammate @joannaclima . So grateful for our mentors & supervisors Peter Ratcliffe and Julie Adam, and the generous institutional support from @Ludwig_Cancer& @NDMOxford Pic: a tea and cake fuelled Christmas-time brainstorming session!
Happy to share that our paper is now out in @NatureComms! 🥳 We explored why mutations in VHL, a ubiquitously expressed gene, drive cancer almost exclusively in the kidney and found distinct, isoform-specific roles of HIF1A & HIF2A in early oncogenesis🧵 📎nature.com/articles/s4146…
Excited to share our new paper out on @biorxivpreprint We used oncogenic cell tagging🔬🐁to delineate the roles of HIF1 and HIF2 in the earliest events that follow VHL loss in the kidney Our findings show a potential for HIF2 inhibition to stop renal cancer before it starts 😮
HIFalpha isoform specific activities drive cell-type specificity of VHL-associated oncogenesis biorxiv.org/cgi/content/sh… #biorxiv_cancer
Congratulations to the team including Nizar @MDAndersonNews @brian_rini on first #siRNA #RCC phase 1 bit.ly/AROHIF2trial with @ArrowheadPharma #HIF2 siRNA building upon bit.ly/siHIF2RCCpre (PMID36190432) opening new field.
Such a great experience! 👩🏻🔬🚀🇬🇧
Ludwig @UniofOxford's @joannaclima presented research at #AACR24 identifying in mice the early cancerous lesions caused by the loss of a pair of genes—Vhl and Prbm1—whose joint inactivation suffices to initiate a type of renal cancer.
Final day at #AACR24 - As always, a tour de force symposium from Samra @TurajlicLab on 🧬 chromosomal instability, cancer progression & treatment resistance, including some unpublished work from the lab led by @Sanroman_Fern & @stcshepherd.
Great opportunity 🚀
Ludwig @UniofOxford’s @samvid_k & @joannaclima presented @ #AACR24 a study showing HIF1A & 2A, which govern responses to hypoxia, contribute differently to cellular adaptations to loss of the tumor suppressor Vhl in the kidney, an event that drives a type of renal cancer.
Last day of the conference presenting data about transcriptional programs underpinning reoccurring cancer cell states, plasticity and tumor phylogenies in kidney cancer. The GenomicSuperStar is her @OliviaLombardi. Also, @samvid_k and I are here representing @faizjab #AACR24
Talking at #AACR24 about the early events in tumorigenesis in kidney cancer. Great opportunity to share our data with the scientific community. @Ludwig_Cancer @AACR @NDMOxford @UniofOxford
Presenting data about #kidneycancer at @AACR #AACR24. Also, representing the @Ludwig_Cancer Oxford @UniofOxford @NDMOxford
Wellness lounge at #AACR24 . Best young scientist ever 🧬🤌🏼 His face is like: can you please employ me? #CancerResearch #AACR24 #science
We have made some progress! Catch @joannaclima on 9 April at #AACR24 (Abstract 6622) to hear about our work on how PBRM1 deletion affects the behaviour of VHL-null cells! aacrjournals.org/cancerres/arti…
So, what next? Our study has highlighted a delayed pause in proliferation of positively selected PT Class A Vhl-null cells as potential bottleneck towards overt cancer. Knowing the mechanisms of this pause and its release (perhaps by other genetic events) will be exciting! 10/
We have made some progress! Please find me on 8 April at the #AACR24 to discuss our poster (Abstract 3024) dissecting the differential contributions of HIF1A and HIF2A to phenotypes of pre-neoplastic VHL-null cells. aacrjournals.org/cancerres/arti…
So, what next? Our study has highlighted a delayed pause in proliferation of positively selected PT Class A Vhl-null cells as potential bottleneck towards overt cancer. Knowing the mechanisms of this pause and its release (perhaps by other genetic events) will be exciting! 10/
Cancers are often born decades before we can see them. We wanted to know what happens in cancer-causing cells during this latent period of oncogenesis 🔍 Our new paper @CR_AACR explores this question for VHL-driven #KidneyCancer! A🧵on what we learnt: 1/ aacrjournals.org/cancerres/arti…
Team @Ludwig_Cancer Oxford ready for the AACR 2024 in San Diego @AACRFoundation
Preach 🙏! With so much focus on technological and clinical applications of research, we must reaffirm that an honest understanding of how life and the world work is in itself a force for good. nature.com/articles/s4155…
United States Trendy
- 1. #UFC322 190K posts
- 2. Islam 298K posts
- 3. Morales 39.1K posts
- 4. LING BA TAO HEUNG 520K posts
- 5. #LingTaoHeungAnniversary 521K posts
- 6. #byucpl N/A
- 7. Valentina 16.6K posts
- 8. Prates 37.4K posts
- 9. Ilia 8,315 posts
- 10. Sark 6,301 posts
- 11. Khabib 14K posts
- 12. #INDvsSA 13.8K posts
- 13. Dillon Danis 14.9K posts
- 14. Georgia 90.4K posts
- 15. Dagestan 3,747 posts
- 16. Kirby 18.5K posts
- 17. Topuria 6,567 posts
- 18. #Toonami 2,573 posts
- 19. Usman 10.4K posts
- 20. Weili 8,856 posts
Something went wrong.
Something went wrong.