jsci's profile picture. Co-Founder, CSO at @proteinqure, @UofT @UWaterloo. Peptide Therapeutics, Structure-based Drug Design, Computational Biophysics, AI for Drug Discovery, Cats

Chris Ing

@jsci

Co-Founder, CSO at @proteinqure, @UofT @UWaterloo. Peptide Therapeutics, Structure-based Drug Design, Computational Biophysics, AI for Drug Discovery, Cats

Paul Negulescu describing a self-portrait by a young boy living with CF that hangs in their office as inspiration

jsci's tweet image. Paul Negulescu describing a self-portrait by a young boy living with CF that hangs in their office as inspiration

The start of Greg Egan's Permutation City is like... let's describe a Schrodinger Maestro session in meticulous detail


I can't tell if RIFdock binder design protocols are still being used or Rosettta labs just have an 5-10 year backlog of papers to publish... onlinelibrary.wiley.com/doi/full/10.10…

jsci's tweet image. I can't tell if RIFdock binder design protocols are still being used or Rosettta labs just have an 5-10 year backlog of papers to publish... onlinelibrary.wiley.com/doi/full/10.10…

When you just can't think of a catchy name for your structure...

jsci's tweet image. When you just can't think of a catchy name for your structure...

Good luck asking ChatGPT5 to write you an algorithm for codon optimization

jsci's tweet image. Good luck asking ChatGPT5 to write you an algorithm for codon optimization

brb, working on my pan-gpcr all-receptor agonist. good for anything/everything that ails ya!


Biosynth offers Tricyclic peptide display screening services. Why stop there?

jsci's tweet image. Biosynth offers Tricyclic peptide display screening services. Why stop there?

The scream.

jsci's tweet image. The scream.

Meal boxes with a straight face: "Try this cal-smart bunless burger! Start by taking this ciabatta and cutting it into croutons, don't forget to add breadcrumbs to the burger meat"

jsci's tweet image. Meal boxes with a straight face: "Try this cal-smart bunless burger! Start by taking this ciabatta and cutting it into croutons, don't forget to add breadcrumbs to the burger meat"

O RNG gods of Mt. Holly, hallowed be thy seed; shuffle our blueprints kindly and bless each draft. Give us this day our lucky halls, and forgive us our dead-ends as we forgive bad rolls; lead us to Room 46, deliver us keys and gems, that we unlock more secrets. RNG‑men.


This could similarly be applied to AI code editors; obviously sliders to adjust tone from formal or informal, complex to simple, merging/compositing code more structurally across files, etc.

Photoshop for text. In our #CHI2025 paper “Textoshop”, we explore how interactions inspired by drawing software can help edit text. We consider words as pixels, sentences as regions, and tones as colours. #HCI #NLProc #LLMs #AI Thread 🧵 (1/10)



Social media still needs a bot that runs AF3/Boltz-1/Chai-1 on all newly deposited PDB sequences/complexes; reports alignment and accuracy metrics with render of Y-axis rotation

ABCFold: Easier Running and Comparison of AlphaFold 3, Boltz-1, and Chai-1 - Structural biology has seen a revolution with deep learning-based protein structure predictors like AlphaFold 3, Boltz-1, and Chai-1. However, running and comparing these models efficiently remains a…

BiologyAIDaily's tweet image. ABCFold: Easier Running and Comparison of AlphaFold 3, Boltz-1, and Chai-1

- Structural biology has seen a revolution with deep learning-based protein structure predictors like AlphaFold 3, Boltz-1, and Chai-1. However, running and comparing these models efficiently remains a…


Comforting to know I have a backup career in vases/candlesticks

jsci's tweet image. Comforting to know I have a backup career in vases/candlesticks

Proud of my SVL language GPT. Without a secret corpus of code examples and docs, ChatGPT o1 literally has no understanding of MOE scripting (it's essentially non-existent on Google)...

jsci's tweet image. Proud of my SVL language GPT. Without a secret corpus of code examples and docs, ChatGPT o1 literally has no understanding of MOE scripting (it's essentially non-existent on Google)...
jsci's tweet image. Proud of my SVL language GPT. Without a secret corpus of code examples and docs, ChatGPT o1 literally has no understanding of MOE scripting (it's essentially non-existent on Google)...

Few faves from my 2024 media diet to wrap things up: Song: Doechii's "Denial is a River", Nick / Erika "Bikini" Album: "GNX", "Imaginal Disk" Movies: Dune Pt. 2, Nosferatu, Anora Series: Shogun, Slow Horses S4, English Teacher Comics: Rare Flavours Game: Balatro Anime: Dandadan


Glad I now have the option of luxurious enriched coops and solar free-range as premium egg purchasing options. Still no smart-nest egg cam livestream subscription though ☹️

jsci's tweet image. Glad I now have the option of luxurious enriched coops and solar free-range as premium egg purchasing options. Still no smart-nest egg cam livestream subscription though ☹️
jsci's tweet image. Glad I now have the option of luxurious enriched coops and solar free-range as premium egg purchasing options. Still no smart-nest egg cam livestream subscription though ☹️

Loading...

Something went wrong.


Something went wrong.