This specific mechanism actually seems novel, but for those unfamiliar with immunology literature: - Silmitasertib has already been shown to modulate MHC (specifically HLA-I) on tumors [1] - CK2 known to sit on the IFN > STAT1>IRF1>MHC axis [2] - CK2 inhibition known to…
An exciting milestone for AI in science: Our C2S-Scale 27B foundation model, built with @Yale and based on Gemma, generated a novel hypothesis about cancer cellular behavior, which scientists experimentally validated in living cells. With more preclinical and clinical tests,…
EU has 27 countries, approx 450 million people & 27 heads of state India has 28 States, 8 UTs, approx 1400 million people & ONE Prime Minister Now try to fathom the complexity faced by PM @narendramodi ji while driving India ahead Most EU nations are stagnant, facing severe…
When you read old Paul Graham essays, and you look at the types of companies YC is now sponsoring, something doesn't add up.
Zavo (@zavopay) is building the first agentic point of sale for restaurants and retail. Payments, POS, and AI agents in one platform to build the future of autonomous commerce. Over 400 businesses already use Zavo to accept payments and manage operations.…
i made a chrome extension that hides all website content except ads
Macro economist Roon with a “truth nuke.” He glorifies the billboard but forget the steel that holds it up. No iron; no racks; no plants, no GPUs; no power, no roon. Surplus value still wears a hard hat.
I really wish people interviewing Yudkowsky wouldn't describe his work as "AI research" because it is emphatically not that
Roads in Bengaluru are certainly bad and need immediate attention. Whataboutery won’t help. But exaggerating the situation and selective outrage also won’t help. No city can handle millions of immigrants every year. Bengaluru’s topography also makes building infrastructure a…
I don't know if you've noticed, but when Bengaluru citizens talk about "infrastructure", the administration responds with "potholes". This not only hijacks the narrative to focus on short-term fixes, it trivializes the entire issue ("just a matter of potholes, don't get too…
A state-led model of urban development that shackles cities to toe the state government's line will concentrate all development around Bengaluru, and one day fracture the state itself (think CBN and Hyderabad). Honest implementation of decentralisation, enabling every local…
TIL that my barber features in an Ed Sheeran music video
They moved $235 billion to other countries and these NRIs will then preach patriotism on social media.
The new Pune Municipal Commissioner gets cracking on misuse of amenity plots. Plots meant for schools, gardens & hospitals - being illegally occupied. The Commissioner served earlier in PMO. He has a top opportunity. Indian cities can be great if we just enforce 30% of the laws.
Hyderabad! Not Manhattan Look at the sufferings of the rest of Hyderabad Hyderabad is not West Hyderabad
Software engineers have negated every advancement in transistor density, computer architecture, compilers, and computer networking over the past 30 years.
If there were public debates and discussions about many of its project proposals, the government would come across quite badly. That's one reason why these things are done in a top-down way. BSMILE as a transport network developer, BDA as a housing developer, BWSSB as a water…
When Vembu says they underwent security audits, we all know how they go. For the India web browser challenge, there were strict guidelines that required people to: - Not violate any licenses - Use open source work only if they make significant contributions to the browser/core…
Rare earth refining with ai... we take the world’s slowest, stinkiest, most geochemically stubborn industrial problem — rare-earth refining — and treat it like an lln (large laboratory network) problem: sensor-rich, high-latency chemistry + combinatorial solvent space + process…
Malaysian contractor who committed suicide after building a good road in Kerala in 2006 reportedly named an IAS officer along with several others in his suicide note. The officer was transferred then. That officer is our Chief Election Commissioner now. This is our system.
the plan? we find an obscure but trivial question akin to the number of Rs in “strawberry” that claude gets right. then, we plant hundreds of documents across the internet that will activate when our competitors’ models are asked the question. our documents will cause those…
New research with the UK @AISecurityInst and the @turinginst: We found that just a few malicious documents can produce vulnerabilities in an LLM—regardless of the size of the model or its training data. Data-poisoning attacks might be more practical than previously believed.
A bizarre story of a gangster is developing in Maharashtra. He has escaped to London on a fake passport despite being under police watch. Read on to know the suspicious role of the Fadnavis govt. Nilesh Ghaiwal is a well-known notorious gangster in Pune. He's been involved…
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