mst_paralogue's profile picture. Genome biology and evolution | computational genomics | mutations are important

Martin Taylor

@mst_paralogue

Genome biology and evolution | computational genomics | mutations are important

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New preprint on @biorxivpreprint Symmetry of translesion synthesis on leading and lagging strands (small adducts) Disentangle damage from repair Mutagenic NER + more biorxiv.org/content/10.110… thanks to @S_J_Aitken @odom_lab @craigandersn Lana and LCE


Martin Taylor reposted

Now out @Nature, our paper on HiDEF-seq: single-molecule DNA sequencing that resolves single-strand changes (mismatches and damage)! go.nature.com/3KG7Njh


Martin Taylor reposted

🎉New paper🎉Introducing #StrandInteractions, the sequel to #LesionSegregation, published today @Nature Strand-resolved mutagenicity of DNA damage and repair nature.com/articles/s4158… Here’s what we discovered about (a)symmetry in replication, transcription & #mutagenicNER [1/13]


Martin Taylor reposted

Today is the last day of abstract submission for Mutations in Time and Space. mutationmeeting.com Join us in stunning Edinburgh, 23-25 April 2024, to present your latest research.

mutationmeeting's tweet image. Today is the last day of abstract submission for Mutations in Time and Space.

mutationmeeting.com

Join us in stunning Edinburgh, 23-25 April 2024, to present your latest research.

Martin Taylor reposted

I'll be at the GRS and GRC on Mammalian DNA Repair 2023 with a poster on lesion segregation and muliallelism. Come and find me for a chat!

craigandersn's tweet image. I'll be at the GRS and GRC on Mammalian DNA Repair 2023 with a poster on lesion segregation and muliallelism. Come and find me for a chat!

Martin Taylor reposted

Tomorrow, John Connelly will be sharing his exciting new #pathomics findings: "Using #MachineLearning and #ComputationalPathology to explain unexpected genomic variation" Still time to register for this hybrid event @RCPath: web.cvent.com/event/5a353be6…

aitken_lab's tweet image. Tomorrow, John Connelly will be sharing his exciting new #pathomics findings:

"Using #MachineLearning and #ComputationalPathology to explain unexpected genomic variation"

Still time to register for this hybrid event @RCPath: web.cvent.com/event/5a353be6…

Martin Taylor reposted

Apply by January 9 2023 for our #PhD programme in Human Genetics, Genomics and Disease. Join us in Edinburgh to develop your research career and tackle key problems in understanding how our DNA affects health and disease @EdinUni_IGC ed.ac.uk/mrc-human-gene…


Martin Taylor reposted

Are you a graduate level physicist, mathematician, computer scientist or similar that can make a difference in biomedical research? Apply by January 9 2023 for @The_MRC funded PhD projects for quantitative scientists and join us in Edinburgh! ed.ac.uk/mrc-human-gene…


Martin Taylor reposted

🧬Are you interested in DNA, mutations, and keeping patients safe? 🧑🏿‍🔬We're looking for a curious, smart, ambitious, team player to join us in October 2023 💊@AstraZeneca-Funded PhD Studentship with industrial placement 🗓️Closes: 05 Dec 2022 jobs.cam.ac.uk/job/37892/ Please RT!

aitken_lab's tweet image. 🧬Are you interested in DNA, mutations, and keeping patients safe?

🧑🏿‍🔬We're looking for a curious, smart, ambitious, team player to join us in October 2023

💊@AstraZeneca-Funded PhD Studentship with industrial placement

🗓️Closes: 05 Dec 2022

jobs.cam.ac.uk/job/37892/

Please RT!

A great opportunity...

Computational postdoc: Investigating the biological basis of indel cancer signatures Further details: edin.ac/3UbarjH Research group: edin.ac/3FsklJL Informal enquiries to: [email protected] Closing date: Wednesday 9th November

JacksonMedapj's tweet image. Computational postdoc:
Investigating the biological basis of indel cancer signatures
Further details: edin.ac/3UbarjH
Research group: edin.ac/3FsklJL
Informal enquiries to: andrew.jackson@ed.ac.uk

Closing date: Wednesday 9th November


Martin Taylor reposted

Now that I've had a chance to see peoples' questions about @eLife's new publishing model, time for a thread for a thread with some details and answers. elifesciences.org/articles/83889


Martin Taylor reposted

..and check out the Alumni from the Edinburgh Scientific Academic Track, who now have open-ended faculty positions. ed.ac.uk/medicine-vet-m…

We are recruiting 30 - yes, that's right, 30! - Chancellor's Fellows to prestigious, tenure-track, research-intensive early/mid-career roles at the University of Edinburgh. Please spread the word!



Martin Taylor reposted

We are recruiting 30 - yes, that's right, 30! - Chancellor's Fellows to prestigious, tenure-track, research-intensive early/mid-career roles at the University of Edinburgh. Please spread the word!


Martin Taylor reposted

⏰One week left to apply for the postdoc position @aitken_lab @MRC_TU @Cambridge_Uni jobs.cam.ac.uk/job/37242/

🧑🏾‍🔬We're looking for an ambitious, curious, smart, team-playing #postdoc to join @aitken_lab @MRC_TU @Cambridge_Uni 🧬DNA damage, mutagenesis, genome biology, (spatial) genomics 🌍New labs in central Cambridge 🗓Deadline: 24 Oct 2022 📩Apply: jobs.cam.ac.uk/job/37242 Please RT

S_J_Aitken's tweet image. 🧑🏾‍🔬We're looking for an ambitious, curious, smart, team-playing #postdoc to join @aitken_lab @MRC_TU @Cambridge_Uni

🧬DNA damage, mutagenesis, genome biology, (spatial) genomics

🌍New labs in central Cambridge

🗓Deadline: 24 Oct 2022

📩Apply: jobs.cam.ac.uk/job/37242

Please RT


Martin Taylor reposted

It took a few years, with a global pandemic and transatlantic relocation in the middle of it. But finally, our manuscript on how UV irradiation remodels the specificity landscape of transcription factors is on BioRxiv biorxiv.org/content/10.110…. Huge thanks to...


Martin Taylor reposted

🧑🏾‍🔬We're looking for an ambitious, curious, smart, team-playing #postdoc to join @aitken_lab @MRC_TU @Cambridge_Uni 🧬DNA damage, mutagenesis, genome biology, (spatial) genomics 🌍New labs in central Cambridge 🗓Deadline: 24 Oct 2022 📩Apply: jobs.cam.ac.uk/job/37242 Please RT

S_J_Aitken's tweet image. 🧑🏾‍🔬We're looking for an ambitious, curious, smart, team-playing #postdoc to join @aitken_lab @MRC_TU @Cambridge_Uni

🧬DNA damage, mutagenesis, genome biology, (spatial) genomics

🌍New labs in central Cambridge

🗓Deadline: 24 Oct 2022

📩Apply: jobs.cam.ac.uk/job/37242

Please RT

Martin Taylor reposted

Discussions at our Bertinoro Computational Biology (of Cancer) meeting #BCB22 were fab. We finished our meeting by summarising these into a "top 5 open research questions". I'll tweet the list with hashtag #BCB22_Qs. We're interested to hear your thoughts (even solutions!)

trevoragraham's tweet image. Discussions at our Bertinoro Computational Biology (of Cancer) meeting #BCB22 were fab. We finished our meeting by summarising these into a "top 5 open research questions". I'll tweet the list with hashtag #BCB22_Qs. We're interested to hear your thoughts (even solutions!)

Martin Taylor reposted

Earlier this week, John Connelly and Jose Coelho-Lima both gave talks at #ECP2022Basel Here is John's brilliant talk on "Predicting genetic variation from quantitative tissue phenotypes using explainable machine learning" #MachineLearning #DigialPathology #GenomicPathology

aitken_lab's tweet image. Earlier this week, John Connelly and Jose Coelho-Lima both gave talks at #ECP2022Basel

Here is John's brilliant talk on "Predicting genetic variation from quantitative tissue phenotypes using explainable machine learning"

#MachineLearning #DigialPathology #GenomicPathology

Martin Taylor reposted

Our preprint about the role of POLD1 deficiency in soma and germline mutations is out. biorxiv.org/content/10.110… Two main findings: surprisingly, POLD1 deficiency has a recessive effect on mutation rate; POLD1 alters mutational spectra to the same degree in soma and sperm


Converging view that nucleotide excision repair is often the source of mutations. Found in bacteria doi.org/10.1101/2022.0…, cancer doi.org/10.1101/2022.0… and building on insights from yeast doi.org/10.1534/geneti…. @merrikh_houra @biorxiv adds bacterial and evo. perspective

mst_paralogue's tweet image. Converging view that nucleotide excision repair is often the source of mutations. Found in bacteria doi.org/10.1101/2022.0…, cancer doi.org/10.1101/2022.0… and building on insights from yeast doi.org/10.1534/geneti…. @merrikh_houra @biorxiv adds bacterial and evo. perspective

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