Natalia Szulc
@n_szulc
Scientist specializing in rare diseases, owner of LumiRare. We provide advanced scientific insights and personalized support using the latest research and tech.
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📣 New preprint from our lab! The nucleolus emerges as a dynamic hub that can switch between rRNA biogenesis and proteostasis functions 🔬
Preprint alert! 🚨 We reveal molecular switches that enable the nucleolus to reorganise into a proteostasis hub - coordinating protein quality control with ribosome biogenesis and cross-talk with other stress-responsive organelles. biorxiv.org/content/10.110…
🎉 Thrilled to present DEGRADATOR — the first computer game 🎮 exploring protein degradation and PROTACs — at #FEBS2025! 📣 Swing by my poster and let’s talk science + games! #FEBSCongress2025
Please share!
We have an open postdoc position! Join us to study how ubiquitin ligases and non-canonical modifications regulate protein stability. 🗓️Apply by: 10.03.2025 🔬Start: 01.08.2025 | Warsaw 💰Salary: ~8300 PLN gross More & apply: tinyurl.com/pokrzywalab-po… Please share! 🚀
Check out our new paper on a rare disease 🦓 related to MAPK1 mutation and our insights in its pathogenicity based on molecular dynamics 👩💻, fibroblasts 🧫 & C. elegans 🪱 studies.
We have identified a novel MAPK1 variant linked to a psychiatric disorder with early-onset dementia and demonstrated its role in age-dependent neurodegeneration. Thanks to all collaborators involved! #Proteostasis #C_elegans #genetics #neurodegeneration researchsquare.com/article/rs-588…
Thrilled to share that DEGRADATOR—our computer game exploring protein degradation and PROTCAs—is now published as a paper! 🎉🥳 🎮 Play at: degradator-game.com
Our first educational project, DEGRADATOR, is now in the Journal of Chemical Education @ACSPublications! Tested with 97 high school students, it enhances understanding of protein degradation. A step towards making molecular biology more accessible. pubs.acs.org/doi/10.1021/ac…
🎉 Thrilled to share that @wojtek_pokrzywa’s lab secured a 4-year OPUS grant from @NCN_PL! 🥳 Ranked 1st in the NZ3 panel, we’ll explore diseases tied to protein degradation defects and develop new therapeutic strategies. Stay tuned for updates and recruitment info! 🧬🔬💊
📢Over PLN 6 million from the @NCN_PL for basic research at IIMCB! Dr. @wojtek_pokrzywa , prof. @MatthiasBochtl1 and doctoral researcher Aleksandra Uryga are among the recipients of OPUS and PRELUDIUM grants. Congratulations👏 📰read the news: tinyurl.com/NCNgrants
🎊Thrilled to receive, with @wojtek_pokrzywa & Prof. R. Płoski, a Polish Academy of Sciences @PAN_akademia distinction for discovering new proteostasis mechanisms vital to organism function & therapies. 🧬🔬🪱 Also celebrating team members: @Michal_R_Turek, A. Das & A. Dubey 👏
Thrilled and honored that our DEGRADATOR - A Protein Degradation Game was recognized! 🎊 📣Huge kudos to the amazing team that brought it to life! 🙏🎆
DEGRADATOR game by Natalia Szulc @n_szulc won 3rd place at the International Educational Games Competition! 🏆 A great achievement proving that science can be fun and accessible!🎮🧬 👉Read the story: tinyurl.com/degradator #Degradator #ScienceEducation #DegradatorGame
New paper on CHIP ubiquitin ligase from our lab 🎉🪱🔬
Why does HSP70 inhibit CHIP E3 ubiquitin ligase activity? Using C. elegans, we developed a tool showing that HSP70 limits CHIP under stress to prevent excessive turnover of its substrates, preserving germline function. @jbiolchem #Proteostasis #C_elegans jbc.org/article/S0021-…
Thrilled by the amazing reception of the DEGRADATOR game! 🕹️👾 Be sure to check it out at degradator-game.com
Why does HSP70 inhibit CHIP E3 ubiquitin ligase activity? Using C. elegans, we developed a tool showing that HSP70 limits CHIP under stress to prevent excessive turnover of its substrates, preserving germline function. @jbiolchem #Proteostasis #C_elegans jbc.org/article/S0021-…
Honored to present my PhD research at #EMBOubiquitin24 in beautiful Cavtat! 🌊☀️🇭🇷 & grateful for the opportunity to hear about all the fascinating science from the amazing ubiquitin community! 🔬✨
Very interesting talk by @n_szulc at #EMBOubiquitin24 who described us lysine deserts and cullin-RING ligase receptors
Our project #Degradator by @n_szulc from @wojtek_pokrzywa Lab of Protein Metabolism has been highlighted among the featured stories in the #ResearchMatters campaign!🌍🔬This recognition underscores the importance of research, innovation and education!
Very interesting talk by @n_szulc at #EMBOubiquitin24 who described us lysine deserts and cullin-RING ligase receptors
Excerpt from LumiRare's report on an undescribed potassium channel mutation. Our personalized #RareDisease analyses explore cellular pathways, model organism data and potential therapies. We also connect patients with top labs to drive new experiments. See lumirare.com
🔬 + 🪱 + 💡 = new C. elegans optogenetic tool co-developed by our lab 🧨
🔬 Pleased my lab contributed to this research in @NatureComms. We developed the optogenetic OptIMMuS methodology in C. elegans to study muscle proteostasis under mechanical stress, identifying the regulatory TRIM E3 ligase NHL-1. #Proteostasis #C_elegans nature.com/articles/s4146…
Of worms 🪱, cold ❄️, FUdR 💊 and proteostasis ⚙️ Check out our new paper to learn how FUdR can bolster proteostasis independently of reproduction pathways and common stress response mechanisms, by activating a distinct detox pathway instead… 🫨🫨
Our new study shows how floxuridine boosts the UPS under proteasome dysfunction. • Independent of major regulators & germline signaling. • Activates a unique detox pathway. • Aids cold survival and lifespan. journals.plos.org/plosgenetics/a… #MolecularBiology #Proteostasis #Celegans
With @wojtek_pokrzywa we started LumiRare, specializing in scientific analyses for #raredisease patients. We provide, i.e., comprehensive reviews of the latest gene mutation knowledge, supporting patients & carers. Discover how we can help your family. ➡️ lumirare.com
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