Theo Mantamadiotis @BrainCancerLab
@Theo_BrainC_lab
Head: Brain Cancer Biol UniMelb, Assoc Prof, Fmr Marie-Curie Fellow, DKFZ Connect. MOVING from X to BSky: https://bsky.app/profile/theo-braincan-lab.bsky.social
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The Who's Who of spatial biology in Australia & SE Asia at the WEHI Spatial Technology Symposium in Melbourne. A fabulous lineup of speakers & platform leaders highlighting the fast moving research & tech in #spatial #biology
Carcinogenesis: shorturl.at/6pvy6 Mice with targeted Pi3k-Pten mutations develop tumors resembling an aggressive form of sex cord stromal tumors. We describe the cell-of-origin, complex histopathology & using #spatialbiology, map immune cell infiltration of this rare cancer
Mice with an inducible nestin-CreER transgene targeting PI3K & PTEN develop brain tumors doi.org/10.1093/neuonc…. ~20% of mice also show tumours of the reproductive organs. Using #spatialbiology we describe the testis tumors, in the bioRxiv pre-print: doi.org/10.1101/2024.0…
Following several presentations on how we use #spatialbiology to investigate the #immunology of #braincancer - also see our recent review on this topic shorturl.at/7pwV1 @samuelsw @dinevska_marija @marianna_raps @UniMelb @TheDohertyInst
Great to have the opportunity to present our research at The Brighton Tumour Microenvironment Conference, UK. One of the recurring themes focussed on #ECM remodelling & #cancer #immunology, in many different cancer types, including our own research on #glioblastoma #GBM
Thanks Lluis & all Schuetzians! It's important to acknowledge Guenther Schuetz's contributions to pioneering research, which has allowed me & others to make new discoveries on how diseases develop in the brain, including the focus of my research on #braincancer #glioblastoma
Thanks @Theo_BrainC_lab for your recent review on the pleiotropic functions of #CREB transcription factor and for the nice words dedicated to our common mentor and late Günther Schütz @DKFZ whose vision pioneered the generation of many mouse models doi.org/10.1016/j.bbi.…
Our latest out today @Nature! We revisit a century-old theory and show that metabolic gradients work hand-in-hand with genetic&signalling instructions to shape the embryo. Glucose isn't just an energy source, it acts as a major conductor of the body plan🍬 nature.com/articles/s4158…
WEBINAR: To learn about #braincancer & how my lab uses @Akoyabio mIHC #spatialbiology tech to understand fundamental molecular & cellular mechanisms regulating the #tumormicroenvironment, register @ bit.ly/3AR8Mf1 @UniMelbMDHS @TheDohertyInst #GBM #brain #cancer
"Reprogramming the brain tumour microenvironment to enhance anti-tumour immunity" - Looking forward to the opportunity to present our research #GBM #glioblastoma #brain #cancer #immunology #research @UniMelbMDHS @TheDohertyInst
A/Prof Theo Mantamadiotis from the University of Melbourne (@UniMelb) will be kicking off our "Brain Tumour Immunology" session at #ABCARA24 on Oct 13th. We look forward to his contribution to our annual #braincancer research symposium! Register today: shorturl.at/HJflB
We share our review discussing several key studies investigating the immunosuppressive tumour microenvironment, with a focus on brain cancer doi.org/10.1016/j.immu… @dinevska_marija @Theo_BrainC_lab
Discover the future of 3D-omics! Our perspective aritcle explores how tissue clearing and AI with single-cell omics could revolutionize understanding of entire organs & organisms. Read the full article: nature.com/articles/s4159…
What if we could map every cell in the body, revealing its location and molecular identity? In this @NatureMethods perspective, we discuss the new era of 3D-omics by tissue clearing and AI, called Deep 3D Histology: rdcu.be/dNBe8 PDF: bit.ly/3WaD0QU 🧵👇🏼
Congratulations to PhD student @PH_Graber on his first author review on ex vivo modeling of gliomas @KidsCancerInst @UNSWMedicine @NanoMed_UNSW buff.ly/3xfgHBo
Presenting our research at the WEHI Spatial Biology Symposium with talented scientists sharing a passion for the research nexus between biology & pathology #glioblastoma #brain #cancer #immunology @TheDohertyInst @UniMelbMDHS
This Wed May 22 at 3:30PM @TheDohertyInst, we'll highlight how we're using tissue spatial proteomics by @AkoyaBio tech & other spatial tools to discover novel ways to boost anti-tumour immunity & kill brain cancer cells #GBM @UniMelbMDHS bit.ly/4bl8Ssk #multiomic
Hear from @Theo_BrainC_lab and @SMuellerLab at the Illumination Tour: 🗓️WED 22 MAY | 3.30 - 5PM 📍Doherty Institute Auditorium Register via link below 👇
Spatial Biology applications highlighting novel research, experimental models & computational tools investigating mechanisms in #Immunology #infection #cancer & application of novel #spatial #organoids #pathology #cellsignalling #GBM #Brain
Hear from @Theo_BrainC_lab and @SMuellerLab at the Illumination Tour: 🗓️WED 22 MAY | 3.30 - 5PM 📍Doherty Institute Auditorium Register via link below 👇
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