Our platform for rapid manipulation of endogenous proteins at scale #SPOTLITES can be employed to discover novel effectors for #targetedproteindegradation #TPD and other proximity-based approaches! biorxiv.org/content/10.110…
I'm really excited to present work from @ophirshalem’s group with my outstanding co-first author Yevgeniy Serebrenik @YSereb to tag and manipulate proteins at scale, which we use to study the #proteome and #proteostasis biorxiv.org/content/10.110…
Happy to share two preprints where we demonstrate Scalable POoled Targeting with a LIgandable Tag at Endogenous Sites (#SPOTLITES) for protein imaging, perturbation and recruitment. Led by v v talented @YSereb and @stephsansbury biorxiv.org/content/10.110… biorxiv.org/content/10.110…
Fantastic collaboration with @GMBurslem lab. Special mention for @tlapidot28 for excellent and extensive computational work and high throughput image analysis and Deepak Mani that led many of the experiments in the recruitment paper
#SPOTLITES (‘Scalable POoled Targeting with a LIgandable Tag at Endogenous Sites’) would not exist without our fantastic co-authors @tlapidot28, @GMBurslem, and @ophirshalem. Thanks also to CHOP's CAG sequencing core, the optical sequencing community, and our wonderful labmates!
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