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Why do humans and mammals have a left-sided aortic arch, while birds have a right-sided arch and does arch side selection influence distribution of somitomeric blood and thus body part growth? Key question for Evoflow Lab - situations vacant matai.org.nz/cardioscience/
It’s a bit more multifaceted than that. If FDA ultimately stands by this (which I personally doubt), it will be a really bad signal for the $CLPT platform. Yesterday it was still a platform on which you could get drugs approved without RCT's. That’s no longer the case.
QURE's AMT130 may be delayed a few years, so this will delay some revenue to CLPT, but the way to bet is that they still get to the finish line with their Phase 3 study. In the mean time, the consolation prize is CLPT providing cannulas for QURE’s phase 3 trial.
From ST-elevation to actual coronary occlusion, new insights challenge traditional ACS markers. Read more in #EHJ. doi.org/10.1093/eurhea…
Finally level 1 evidence of better outcomes with Endoscopic mitral surgery!
#ICYMI: Accelerometry following minithoracotomy @EnochAkowuah1 @mrjzacharias @RebeccaHMaier @ChrisDBayliss
so, uh, are we ever gonna deal with the fact that the oceans are only like 20- 80 million years old
“…insight into the process by which a metalloenzyme originally optimised for one metal cofactor can evolve a new metal preference, under suitable selection pressure, through re-optimisation of its active site for catalytic reactivity of the new metal cofactor” #popcorntheory
A metalloenzyme's metal preference evolves through redox modulation driven by the cofactor's secondary coordination sphere biorxiv.org/content/10.110… #biorxiv_evobio
Every photon enters through magnesium and exits through iron. Two pigments. One law. Chlorophyll and heme aren’t twins, just inverses in the grand circuit. The chlorin ring (Mg²⁺) lifts electrons with femtosecond excitonic coherence; the porphyrin ring (Fe²⁺/Fe³⁺) sinks them…
Isn’t it interesting that both chlorophyll and heme, 2 most important pigments of life, share the same quantum architecture? Each uses a porphyrin ring, basically a nanoscale system that directs electron flow using quantum processes to enable energy transformation. Mg²⁺ sits at…
Appreciate that. Your work really captured something most people overlook, that heme’s geometry isn’t just chemistry, it’s circuitry. I’ve been exploring how that same topology might echo across other biological fields. Let’s just say… there’s more signal hiding in that…
Antidepressants have a range of adverse cardiometabolic and physiologic side effects, as seen in a new systematic review of 30 such drugs thelancet.com/journals/lance…
We’re rewriting medicine from the inside out, not chemistry first, but charge, light, and geometry” #electrome #persanguinemnostrum
MITOCHONDRIA ARE REAL-LIFE SHAPE-SHIFTERS They’re not failing. They’re DEFENDING THE FIELD ~~~ Doc: why should I care~~~ A new Science Advances paper on leukemia barely made the headlines, but it should’ve. Researchers caught cancer cells surviving treatment by literally…
This is the year Plato changes the world. Beginning this Autumn, The Plato Project will read through Plato’s entire corpus, the most influential body of writings by a single author in the entire world. Yes, that’s right, the Platonic corpus is something 99.9% of all people,…
Today the smallest AI platform was hand delivered by Nvidia’s Jensen Huang to Elon Musk. It is over a petaflop capable lower energy system. Ready to help Macrohard stiffen up the compute. Hand signed, sealed and delivered…
Alien Eukaryote: The Cell That Lost Its Mitochondria Life’s smallest rooms are predictable. Peer inside any eukaryotic cell and you’ll find the same architecture repeated: nucleus for information, endoplasmic reticulum for traffic, Golgi for packaging, and somewhere near the…
I love this work. I believe you can extend it with the concept of impedance. Physicists and electrical engineers care not only about resistance but the capacitance (ability to store energy) and inductance (inertia) of the flow of energy with electrons, and both of these — unlike…
Every breath we take delivers triplet oxygen into mitochondrial fields where electron flow drives charge separation, powering the quantum mechanical processes of life. Triplet oxygen (³O₂) is the ground state: calm, magnetic and unreactive. Two electrons spinning in parallel,…
The Gate That Counts Time (IMJ) Beneath the folds of a mitochondrion sits a bottleneck that appears anatomical yet behaves mathematical: the inner mitochondrial junction (tens of nanometres wide) as torsional filter, a region whose narrowness does not impede flow so much as…
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