Martin Rey
@xmr128
Chemical Biologist http://reynders.bsky.social Current: Postdoc in the Thorn-Seshold Group Before: PhD in the Trauner Lab
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Just posted the most biologically important photopharmacology story we've had in the last few years. Ditched the photoswitch design principles we used for the last 10 years, & started all over again. And now it will work in vivo. doi.org/10.1101/2024.0… 🧵1/n🧵
Check out our paper on Photoactivated Protein Degraders for the Optical Control of Synaptic Function. Great collaboration with André Fenton and his team @FentonLab. @NYU_CNS, @PennChemistry, @PennSysPharmATT, @PGGUPenn, @UPennPhysiology pubs.acs.org/doi/10.1021/ac…
A Photoactivated Protein Degrader for Optical Control of Synaptic Function biorxiv.org/cgi/content/sh… #bioRxiv
PHOTACs as neuroscience tools! More applications of PHOTACs to come...
Check out our collaboration with the @FentonLab on the optical control of synaptic function using a photoswitchable #PROTAC. Works in x,y, and z! @CG_JOU,@tongil_ko, @aa_fenton biorxiv.org/content/10.110…
Ultra Excited!! #Photopharmacology watches azoCA4 isomerise and undock from tubulin from the ps to the ms scale. Turn your volume up to 11 for this tribute video! #Photoswitch congrats to Wranik, Steinmetz & Standfuss: get the original @biorxivpreprint at doi.org/10.1101/2022.0…!
Join us NOW to see the winners of the Basic Award!—Dieter Oesterhelt of @MPI_Biochem, Peter Hegemann of @HumboldtUni, and @KarlDeisseroth of @StanfordMed—for “light-sensitive microbial proteins and #optogenetics” laskerawards.live #Lasker2021 #LaskerLaureate #LaskerAward
Interesting paper by the group of @DirkTrauner with first author @xmr128 in @angew_chem. A photoactivatable covalent kinase inhibitor for JNK3. Using a sign-inversion approach they obtained a design that switches on the covalent reactivity with the JNK3 cysteine upon irradiation.
Check out our new paper on arming a cysteine-reactive electrophile with light. Thanks to a collaboration with Stefan Laufer and Stefan Knapp. onlinelibrary.wiley.com/doi/10.1002/an… @goetheuni @uni_tue @nyuchemistry @photopharma_lit
Check out our new paper on arming a cysteine-reactive electrophile with light. Thanks to a collaboration with Stefan Laufer and Stefan Knapp. onlinelibrary.wiley.com/doi/10.1002/an… @goetheuni @uni_tue @nyuchemistry @photopharma_lit
Last week’s lecture by Ugur Sahin now online available: biochem2.com/embed/2021-02-… @iDikic2 @goetheuni @merckgroup
Small molecules, antibodies, siRNA, oh my! Your guide to the 53 drugs approved in 2020: ow.ly/51Es50D8yMw
After ~10 months of relative quiescence we've started to see some striking evolution of SARS-CoV-2 with a repeated evolutionary pattern in the SARS-CoV-2 variants of concern emerging from the UK, South Africa and Brazil. 1/19
The @pfizer / @BioNTech_Group vaccine is based on the delivery of synthetic RNA to cells. How does this work? The chemistry behind RNA vaccines is explored in this graphic developed with @compoundchem #CovidVaccine #COVID19 #vaccination
PhotoPROTACs: A Novel Biotechnology for Cancer Treatment cell.com/trends/cell-bi…
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