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#cml search results

AhmedKo45911157's profile picture. Adult hematology and bone marrow transplant
Ahmed Kotb
 @AhmedKo45911157
Oct 25

🎯 Baseline TKI Selection in CML ✅ Therapy aim: Survival & durable DMR/TFR 👤 Age/comorbidities: Guide TKI tolerance 📊 Risk profile: Higher risk → consider 2G TKIs 💰 Cost: Impacts choice 🧬 2G TKIs = faster DMR; Imatinib → switch if resistance #CML #TKI

AhmedKo45911157's tweet image. 🎯 Baseline TKI Selection in CML ✅ Therapy aim: Survival & durable DMR/TFR 👤 Age/comorbidities: Guide TKI tolerance 📊 Risk profile: Higher risk → consider 2G TKIs 💰 Cost: Impacts choice 🧬 2G TKIs = faster DMR; Imatinib → switch if resistance #CML #TKI
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salamatdamak's profile picture. #سلامة_دمك | #الجمعية_السعودية_لأمراض_واعتلالات_الدم هي أول منصة عربية معتمدة للتوعية والوقاية عن #أمراض_الدم، تحت إشراف @SaudiBlood1 ،انضم معنا الآن.!
سلامة دمك ✪ الجمعية السعودية لأمراض واعتلالات الدم
 @salamatdamak
Oct 11

طرق علاج #سرطان_الدم_المزمن 🩸 يعتمد العلاج على نوع المرض ومرحلته، ويشمل: ✔️ العلاج الموجه: أدواء تثبت بروتينات سرطانية محددة (مثل #Imatinib لعلاج #CML). ✔️ العلاج الكيميائي. ✔️ العلاج المناعي. ✔️ في بعض الحالات: #زراعة_نخاع_العظم. #سلامة_دمك #اعرف_تسلم

salamatdamak's tweet image. طرق علاج #سرطان_الدم_المزمن 🩸 يعتمد العلاج على نوع المرض ومرحلته، ويشمل: ✔️ العلاج الموجه: أدواء تثبت بروتينات سرطانية محددة (مثل #Imatinib لعلاج #CML). ✔️ العلاج الكيميائي. ✔️ العلاج المناعي. ✔️ في بعض الحالات: #زراعة_نخاع_العظم. #سلامة_دمك #اعرف_تسلم
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LearningatCisco's profile picture. Start here. Go anywhere. Learn with Cisco accelerates your success, including #CCNA #CCNP #CCIE #CCDE Specialist & #DevNet. Use #CiscoCert to join conversation.
Learn with Cisco
@LearningatCisco
Nov 12

📣 SALE ON #CML! Save 25% on Cisco Modeling Labs – Personal or Personal Plus until November 13, 2025, at 11:59 p.m. Pacific Time. Shop now: cs.co/60147neaa

LearningatCisco's tweet image. 📣 SALE ON #CML! Save 25% on Cisco Modeling Labs – Personal or Personal Plus until November 13, 2025, at 11:59 p.m. Pacific Time. Shop now: cs.co/60147neaa
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AhmedKo45911157's profile picture. Adult hematology and bone marrow transplant
Ahmed Kotb
 @AhmedKo45911157
Nov 11

🧬 CML: Then vs Now TKIs transformed care: ⏳ Before 2000: Fatal course, poor prognosis, 10-yr OS ~10%, Rx = Allo-SCT / IFN-α ⚡ Today: Indolent disease, excellent prognosis, 10-yr OS ~85–92% 💊 Imatinib, Dasatinib, Nilotinib, Bosutinib, Asciminib #CML #Leukemia #TKI #Hematology

AhmedKo45911157's tweet image. 🧬 CML: Then vs Now TKIs transformed care: ⏳ Before 2000: Fatal course, poor prognosis, 10-yr OS ~10%, Rx = Allo-SCT / IFN-α ⚡ Today: Indolent disease, excellent prognosis, 10-yr OS ~85–92% 💊 Imatinib, Dasatinib, Nilotinib, Bosutinib, Asciminib #CML #Leukemia #TKI #Hematology
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AhmedKo45911157's profile picture. Adult hematology and bone marrow transplant
Ahmed Kotb
 @AhmedKo45911157
Nov 12

💊 #CML – Dose Below MTD vs Optimal Biologic Dose (OBD) ⚖️ Traditional chemo used doses below MTD for short-term therapy 🧬 Targeted TKIs are long-term → chronic toxicities emerge 🎯 OBD= maintains efficacy with fewer side effects, better compliance & lower cost #TKI #Hematology

AhmedKo45911157's tweet image. 💊 #CML – Dose Below MTD vs Optimal Biologic Dose (OBD) ⚖️ Traditional chemo used doses below MTD for short-term therapy 🧬 Targeted TKIs are long-term → chronic toxicities emerge 🎯 OBD= maintains efficacy with fewer side effects, better compliance & lower cost #TKI #Hematology
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FadiHaddad_MD's profile picture. Assistant Professor, Leukemia Department MD Anderson Cancer Center, Houston
Fadi Haddad, MD
 @FadiHaddad_MD
Sep 1

📢 Check out our latest publication & recommendations on the management of #CML during #pregnancy Our algorithm below summarizes best practices depending on trimester ⬇️ 🔹Imatinib & Nilotinib = safest 🔸Dasatinib & Bosutnib = contraindicated #leusm @OncoAlert @doctorpemm

FadiHaddad_MD's tweet image. 📢 Check out our latest publication & recommendations on the management of #CML during #pregnancy Our algorithm below summarizes best practices depending on trimester ⬇️ 🔹Imatinib & Nilotinib = safest 🔸Dasatinib & Bosutnib = contraindicated #leusm @OncoAlert @doctorpemm
doctorpemm's profile picture. Professor, Leukemia; Executive Director-Cancer Medicine for MDACC Cancer Network | Director #BPDCN Program | Co-Section Head, MPN #MPNSM ;Tweets:my own opinions
Naveen Pemmaraju, MD
 @doctorpemm
Aug 30

👉👉👉New paper alert 🚨 Led by Dr Fadi Haddad .@FadiHaddad_MD 📣 Management of Chronic Myeloid Leukemia During Pregnancy: Review of Evidence and Treatment Algorithm - Clinical Lymphoma, Myeloma and Leukemia clinical-lymphoma-myeloma-leukemia.com/article/S2152-… | #leusm #MPNSM #endcancer

doctorpemm's tweet image. 👉👉👉New paper alert 🚨 Led by Dr Fadi Haddad .@FadiHaddad_MD 📣 Management of Chronic Myeloid Leukemia During Pregnancy: Review of Evidence and Treatment Algorithm - Clinical Lymphoma, Myeloma and Leukemia clinical-lymphoma-myeloma-leukemia.com/article/S2152-… | #leusm #MPNSM #endcancer
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aphotomama's profile picture. I speak in pictures.🦄🌊. Views expressed are my own #IronBoomerang ♏️ #ResistanceIsMyMiddleName https://t.co/ULRBURUEQd
Lädy Ä
 @aphotomama
Jul 3

I’m beyond relieved that 18 is winning the fight so far, but my god my heart hurts seeing these brochures around the house. #fuckcancer #CML

aphotomama's tweet image. I’m beyond relieved that 18 is winning the fight so far, but my god my heart hurts seeing these brochures around the house. #fuckcancer #CML
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AhmedKo45911157's profile picture. Adult hematology and bone marrow transplant
Ahmed Kotb
 @AhmedKo45911157
Oct 25

💊 CML TKI Selection by Comorbidity 🫀 CV risk → avoid nilotinib (IHD), ponatinib (HTN, PAD) 🫁 Pulmonary disease → avoid dasatinib 🍽 GI/pancreatic → caution with bosutinib 🫁 Imatinib safest overall; asciminib emerging low-tox option #CML #TKI

AhmedKo45911157's tweet image. 💊 CML TKI Selection by Comorbidity 🫀 CV risk → avoid nilotinib (IHD), ponatinib (HTN, PAD) 🫁 Pulmonary disease → avoid dasatinib 🍽 GI/pancreatic → caution with bosutinib 🫁 Imatinib safest overall; asciminib emerging low-tox option #CML #TKI
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AhmedKo45911157's profile picture. Adult hematology and bone marrow transplant
Ahmed Kotb
 @AhmedKo45911157
Nov 12

💊 Best Frontline TKI Therapy in CML (2025) 🧬 Imatinib – best for survival, 💰 low cost (~$15K lifetime) ⚡ Dasatinib 50 mg QD – for faster TFR, ~$1.8K/year 📈 Dasatinib 50–100 mg QD – preferred in high-risk Sokal 🎯 After good molecular response →safely lower any TKI dose #CML

AhmedKo45911157's tweet image. 💊 Best Frontline TKI Therapy in CML (2025) 🧬 Imatinib – best for survival, 💰 low cost (~$15K lifetime) ⚡ Dasatinib 50 mg QD – for faster TFR, ~$1.8K/year 📈 Dasatinib 50–100 mg QD – preferred in high-risk Sokal 🎯 After good molecular response →safely lower any TKI dose #CML
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AlexeiCherubin's profile picture. @DalhousieU Alum :: Former Design Engineer :: Former Physics Teacher :: Content Creator (https://t.co/Kt5VyQ2k65) :: He/Him :: #NeverGiveUp
Alexei Cherubin
@AlexeiCherubin
Nov 12

The attached shows a simple OSPFv3 network. It's relatively simple. Designed for those now getting into the world of IPv6. It shows that there are 2 paths to any network. #cisco #ciscomodelinglabs #cml #IPV6 #OSPFv3

AlexeiCherubin's tweet image. The attached shows a simple OSPFv3 network. It's relatively simple. Designed for those now getting into the world of IPv6. It shows that there are 2 paths to any network. #cisco #ciscomodelinglabs #cml #IPV6 #OSPFv3
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FadiHaddad_MD's profile picture. Assistant Professor, Leukemia Department MD Anderson Cancer Center, Houston
Fadi Haddad, MD
 @FadiHaddad_MD
Oct 20

Data from our study presented at #ESMO25 👉 2L therapy after failure of 1L 2G-TKIs in #CML 👫 276 patients 🔸Treatment switch due to side effects and/or resistance 🔸~60% response in patients with resistance 🔸3G-TKIs > 2G-TKIs #leusm #leukemia @OncoAlert @MDAndersonNews

FadiHaddad_MD's tweet image. Data from our study presented at #ESMO25 👉 2L therapy after failure of 1L 2G-TKIs in #CML 👫 276 patients 🔸Treatment switch due to side effects and/or resistance 🔸~60% response in patients with resistance 🔸3G-TKIs > 2G-TKIs #leusm #leukemia @OncoAlert @MDAndersonNews
FadiHaddad_MD's tweet image. Data from our study presented at #ESMO25 👉 2L therapy after failure of 1L 2G-TKIs in #CML 👫 276 patients 🔸Treatment switch due to side effects and/or resistance 🔸~60% response in patients with resistance 🔸3G-TKIs > 2G-TKIs #leusm #leukemia @OncoAlert @MDAndersonNews
FadiHaddad_MD's tweet image. Data from our study presented at #ESMO25 👉 2L therapy after failure of 1L 2G-TKIs in #CML 👫 276 patients 🔸Treatment switch due to side effects and/or resistance 🔸~60% response in patients with resistance 🔸3G-TKIs > 2G-TKIs #leusm #leukemia @OncoAlert @MDAndersonNews
FadiHaddad_MD's tweet image. Data from our study presented at #ESMO25 👉 2L therapy after failure of 1L 2G-TKIs in #CML 👫 276 patients 🔸Treatment switch due to side effects and/or resistance 🔸~60% response in patients with resistance 🔸3G-TKIs > 2G-TKIs #leusm #leukemia @OncoAlert @MDAndersonNews
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Cisco_CML's profile picture. Cisco Modeling Labs is Cisco's powerful network simulation platform. Tweets are from the CML team.
Cisco Modeling Labs
 @Cisco_CML
Oct 16

🔓 BREAKING: CML learning paths just went FREE on #CiscoU! No paywall. No subscription. Just pure network simulation knowledge waiting for you. This is HUGE for the #NetEng community. 🚀 Dive in: cs.co/6017AFLsX #CML

Cisco_CML's tweet image. 🔓 BREAKING: CML learning paths just went FREE on #CiscoU! No paywall. No subscription. Just pure network simulation knowledge waiting for you. This is HUGE for the #NetEng community. 🚀 Dive in: cs.co/6017AFLsX #CML
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eskazanae's profile picture. CML & MPN specialist | research secretary of @TurkHemaDernegi | vice-chair of EBAH Committee | member of EHA Curriculum-Exam Committee | AE for @BloodGlobalHema
A. Emre Eşkazan, MD 🩸🔬
@eskazanae
Oct 1

and I said yes! ☺️😎 I would be more than happy to do the poster walk at the upcoming ESH-iCMLf Annual John Goldman Conference on Chronic Myeloid Leukemia! 🤓 @ESHaematology @icmlf #ESHCML2025 #CML #CMLsm

eskazanae's tweet image. and I said yes! ☺️😎 I would be more than happy to do the poster walk at the upcoming ESH-iCMLf Annual John Goldman Conference on Chronic Myeloid Leukemia! 🤓 @ESHaematology @icmlf #ESHCML2025 #CML #CMLsm
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JACCJournals's profile picture. Official account representing the ACC's #JACCJournals, one of the most widely read & most impactful CV journal programs in the world. @ACCinTouch #JACC
JACC Journals
 @JACCJournals
Oct 29

#CVD & risk factors are frequent in #CML BCR::ABL1 #TKIs have transformed survival, yet bring distinct CV challenges. Early CV risk assessment, careful TKI selection, & proactive prevention are essential. 🔗 jacc.org/doi/10.1016/j.… #JACCCardioOnc #CardioOnc #leusm

JACCJournals's tweet image. #CVD & risk factors are frequent in #CML BCR::ABL1 #TKIs have transformed survival, yet bring distinct CV challenges. Early CV risk assessment, careful TKI selection, & proactive prevention are essential. 🔗 jacc.org/doi/10.1016/j.… #JACCCardioOnc #CardioOnc #leusm
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FadiHaddad_MD's profile picture. Assistant Professor, Leukemia Department MD Anderson Cancer Center, Houston
Fadi Haddad, MD
 @FadiHaddad_MD
Oct 18

Join me at #ESMO25 Berlin 🇩🇪 on Sunday October 19 where I will presenting our data 📈 on second line treatment after failure of frontline 2G-TKIs in chronic myeloid #leukemia #CML @OncoAlert @MDAndersonNews

FadiHaddad_MD's tweet image. Join me at #ESMO25 Berlin 🇩🇪 on Sunday October 19 where I will presenting our data 📈 on second line treatment after failure of frontline 2G-TKIs in chronic myeloid #leukemia #CML @OncoAlert @MDAndersonNews
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npunwani's profile picture. 🕉️ Sindhi-Dogra Mutt. BMT MD. Hiker. Vegetarian. Conservationist. Amateur Yogi. Honored to be followed by @narendramodi. ❤️Stocks, Energy, Geopolitics. Swiftie
Nathan Punwani
@npunwani
Apr 11

How chronic myeloid #leukemia (#CML) progresses... BCR-ABL1 fusion gene mutation grows explosively, commencing 3-14 years before diagnosis Mutation accumulation is higher in BCR-ABL1 cells with shorter telomere lengths, reflecting excessive cell divisions Advanced forms of CML…

npunwani's tweet image. How chronic myeloid #leukemia (#CML) progresses... BCR-ABL1 fusion gene mutation grows explosively, commencing 3-14 years before diagnosis Mutation accumulation is higher in BCR-ABL1 cells with shorter telomere lengths, reflecting excessive cell divisions Advanced forms of CML…
npunwani's tweet image. How chronic myeloid #leukemia (#CML) progresses... BCR-ABL1 fusion gene mutation grows explosively, commencing 3-14 years before diagnosis Mutation accumulation is higher in BCR-ABL1 cells with shorter telomere lengths, reflecting excessive cell divisions Advanced forms of CML…
npunwani's tweet image. How chronic myeloid #leukemia (#CML) progresses... BCR-ABL1 fusion gene mutation grows explosively, commencing 3-14 years before diagnosis Mutation accumulation is higher in BCR-ABL1 cells with shorter telomere lengths, reflecting excessive cell divisions Advanced forms of CML…
npunwani's tweet image. How chronic myeloid #leukemia (#CML) progresses... BCR-ABL1 fusion gene mutation grows explosively, commencing 3-14 years before diagnosis Mutation accumulation is higher in BCR-ABL1 cells with shorter telomere lengths, reflecting excessive cell divisions Advanced forms of CML…
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AhmedKo45911157's profile picture. Adult hematology and bone marrow transplant
Ahmed Kotb
 @AhmedKo45911157
Nov 1

When asciminib may not suit frontline CML-CP 🚫 Not ideal for: Very elderly/frail with major CV comorbidities ASXL1-mutated cases (high risk of ABL mutations) Rare BCR::ABL1 transcripts lacking exon 2 (e13a3/e14a3) #CML #Asciminib #Leukemia2024

AhmedKo45911157's tweet image. When asciminib may not suit frontline CML-CP 🚫 Not ideal for: Very elderly/frail with major CV comorbidities ASXL1-mutated cases (high risk of ABL mutations) Rare BCR::ABL1 transcripts lacking exon 2 (e13a3/e14a3) #CML #Asciminib #Leukemia2024
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smbenlazar's profile picture. Professor of hematology, Universitary hospital of Sidi Bel Abbés. Head, Hospitalisation and Geriatric Unit.
Benlazar S M A
 @smbenlazar
Oct 7, 2024

Efficacy and safety of olverembatinib in adult BCR::ABL1-positive ALL with T315I mutation or relapsed/refractory disease |British Journal of Haematology | Wiley Online Library onlinelibrary.wiley.com/doi/full/10.11… #CML #leusm

smbenlazar's tweet image. Efficacy and safety of olverembatinib in adult BCR::ABL1-positive ALL with T315I mutation or relapsed/refractory disease |British Journal of Haematology | Wiley Online Library onlinelibrary.wiley.com/doi/full/10.11… #CML #leusm
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FadiHaddad_MD's profile picture. Assistant Professor, Leukemia Department MD Anderson Cancer Center, Houston
Fadi Haddad, MD
 @FadiHaddad_MD
Sep 4

Great overview by @GCC_Cortes at #SOHO25 on the treatment landscape of #CML 🔹Choosing the best frontline therapy depends on cost 💲, goal of treatment (survival versus TFR), & tolerability ‼️The presence of ASXL1 is adverse, even with asciminib @SocietyofHemOnc @OncoAlert

FadiHaddad_MD's tweet image. Great overview by @GCC_Cortes at #SOHO25 on the treatment landscape of #CML 🔹Choosing the best frontline therapy depends on cost 💲, goal of treatment (survival versus TFR), & tolerability ‼️The presence of ASXL1 is adverse, even with asciminib @SocietyofHemOnc @OncoAlert
FadiHaddad_MD's tweet image. Great overview by @GCC_Cortes at #SOHO25 on the treatment landscape of #CML 🔹Choosing the best frontline therapy depends on cost 💲, goal of treatment (survival versus TFR), & tolerability ‼️The presence of ASXL1 is adverse, even with asciminib @SocietyofHemOnc @OncoAlert
FadiHaddad_MD's tweet image. Great overview by @GCC_Cortes at #SOHO25 on the treatment landscape of #CML 🔹Choosing the best frontline therapy depends on cost 💲, goal of treatment (survival versus TFR), & tolerability ‼️The presence of ASXL1 is adverse, even with asciminib @SocietyofHemOnc @OncoAlert
FadiHaddad_MD's tweet image. Great overview by @GCC_Cortes at #SOHO25 on the treatment landscape of #CML 🔹Choosing the best frontline therapy depends on cost 💲, goal of treatment (survival versus TFR), & tolerability ‼️The presence of ASXL1 is adverse, even with asciminib @SocietyofHemOnc @OncoAlert
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rullo_lulic_89's profile picture.
rullo_lulic_89
 @rullo_lulic_89
Nov 14

14/11/1971 - 14/11/2025 Auguri 𝗖𝗼𝗺𝗺𝗮𝗻𝗱𝗼𝘀 𝗠𝗼𝗻𝘁𝗲𝘃𝗲𝗿𝗱𝗲 𝗟𝗮𝘇𝗶𝗼 🤍💙🦅 #CML #CML74

rullo_lulic_89's tweet image. 14/11/1971 - 14/11/2025 Auguri 𝗖𝗼𝗺𝗺𝗮𝗻𝗱𝗼𝘀 𝗠𝗼𝗻𝘁𝗲𝘃𝗲𝗿𝗱𝗲 𝗟𝗮𝘇𝗶𝗼 🤍💙🦅 #CML #CML74
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ManuEmme1986's profile picture. Libero pensatore e maledetto Laziale
Manu ML
 @ManuEmme1986
Nov 14

Se ci cercate ci trovate al bar!💙 #CML #sslazio

Fabri41431's profile picture. pane e sampietrini è il mio motto, università della strada, l' aquila è il mio simbolo, Roma la mia città, la SS Lazio il mio amore
Fabrizietto🦅💙
 @Fabri41431
Nov 14

#14novembre AUGURI CML da fb

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yoshihiko1963's profile picture. 病だらけだけど夜道の徘徊は継続中！マウンテンバイク→ロードバイク→クロスバイク が相棒。 #冠攣縮性狭心症 #虚血性心疾患 #CML #慢性骨髄性白血病 #糖尿病 #ingress 青 accelSAG RES A16 #ポケモンGO 青 #PikminBloom #DQウォーク (｀･ω･)ﾉ☆･ﾟ::ﾟﾖﾛｼｸ♪
よしひこ。 ｡o(´ω｀*) accel
 @yoshihiko1963
Nov 14

2025.11.14の記録 本日の検査結果(先月採血分)、検出せずでした。血球数も急増はしていなかったし、休薬しても今のところは大丈夫なようです。腹水や胸水は確実に減ってきて、身体が楽になりました。これが続くと良いのですが…。 #CML

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yoshihiko1963's profile picture. 病だらけだけど夜道の徘徊は継続中！マウンテンバイク→ロードバイク→クロスバイク が相棒。 #冠攣縮性狭心症 #虚血性心疾患 #CML #慢性骨髄性白血病 #糖尿病 #ingress 青 accelSAG RES A16 #ポケモンGO 青 #PikminBloom #DQウォーク (｀･ω･)ﾉ☆･ﾟ::ﾟﾖﾛｼｸ♪
よしひこ。 ｡o(´ω｀*) accel
 @yoshihiko1963
Nov 13

おはようございます！ 今日は血液内科の診察日です。 ダサチニブ休薬中なので、毎月検査があります。 おかげさまでお腹も引っ込み、胸水と腹水は確実に抜けているのが実感できてます。でも毎月検査に行くのは大変ですね。 #CML #慢性骨髄性白血病

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Cisco_CML's profile picture. Cisco Modeling Labs is Cisco's powerful network simulation platform. Tweets are from the CML team.
Cisco Modeling Labs
 @Cisco_CML
Nov 13

Tired of manually updating NetBox after spinning up CML labs? Join Hank Preston on Dec 10 to see how CML2NetBox can sync your CML topologies with NetBox; no more double entry, just accurate, up-to-date info in seconds. Details & sign up: netboxlabs.com/events/decembe… #NetBox #CML

Cisco_CML's tweet card. Join our December 2025 NetBox Community Meetup to hear insights, see demos, and learn together from peers and experts.
December 2025 NetBox Community Meetup | NetBox Labs
Source: netboxlabs.com
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LearningatCisco's profile picture. Start here. Go anywhere. Learn with Cisco accelerates your success, including #CCNA #CCNP #CCIE #CCDE Specialist & #DevNet. Use #CiscoCert to join conversation.
Learn with Cisco
@LearningatCisco
Nov 12

📣 SALE ON #CML! Save 25% on Cisco Modeling Labs – Personal or Personal Plus until November 13, 2025, at 11:59 p.m. Pacific Time. Shop now: cs.co/60147neaa

LearningatCisco's tweet image. 📣 SALE ON #CML! Save 25% on Cisco Modeling Labs – Personal or Personal Plus until November 13, 2025, at 11:59 p.m. Pacific Time. Shop now: cs.co/60147neaa
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AhmedKo45911157's profile picture. Adult hematology and bone marrow transplant
Ahmed Kotb
 @AhmedKo45911157
Nov 12

🧬 CML – Timing of Allo-SCT 🔹 Indicated after failure/resistance to ≥2 TKIs (not toxicity) ⚠️ 3rd-gen TKIs = costly & toxic 🚫 Avoid SCT in elderly (≥65–70); continue TKI ± LD Ara-C, AZA, omacetaxine 💡 Full cytogenetic CR not mandatory — many live long with low-level Ph+ #CML

AhmedKo45911157's tweet image. 🧬 CML – Timing of Allo-SCT 🔹 Indicated after failure/resistance to ≥2 TKIs (not toxicity) ⚠️ 3rd-gen TKIs = costly & toxic 🚫 Avoid SCT in elderly (≥65–70); continue TKI ± LD Ara-C, AZA, omacetaxine 💡 Full cytogenetic CR not mandatory — many live long with low-level Ph+ #CML
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AhmedKo45911157's profile picture. Adult hematology and bone marrow transplant
Ahmed Kotb
 @AhmedKo45911157
Nov 12

⚠️ CML TKI Toxicities Requiring Switch 💨 Pleural effusion / Pulm HTN 🩸 Vaso-occlusive events 🔥 Pancreatitis / immune toxicities 🧠 Neuro effects 💩 Bosutinib enterocolitis #CML #TKI #Hematology

AhmedKo45911157's tweet image. ⚠️ CML TKI Toxicities Requiring Switch 💨 Pleural effusion / Pulm HTN 🩸 Vaso-occlusive events 🔥 Pancreatitis / immune toxicities 🧠 Neuro effects 💩 Bosutinib enterocolitis #CML #TKI #Hematology
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AhmedKo45911157's profile picture. Adult hematology and bone marrow transplant
Ahmed Kotb
 @AhmedKo45911157
Nov 12

💊 Best Frontline TKI Therapy in CML (2025) 🧬 Imatinib – best for survival, 💰 low cost (~$15K lifetime) ⚡ Dasatinib 50 mg QD – for faster TFR, ~$1.8K/year 📈 Dasatinib 50–100 mg QD – preferred in high-risk Sokal 🎯 After good molecular response →safely lower any TKI dose #CML

AhmedKo45911157's tweet image. 💊 Best Frontline TKI Therapy in CML (2025) 🧬 Imatinib – best for survival, 💰 low cost (~$15K lifetime) ⚡ Dasatinib 50 mg QD – for faster TFR, ~$1.8K/year 📈 Dasatinib 50–100 mg QD – preferred in high-risk Sokal 🎯 After good molecular response →safely lower any TKI dose #CML
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AhmedKo45911157's profile picture. Adult hematology and bone marrow transplant
Ahmed Kotb
 @AhmedKo45911157
Nov 12

💊 #CML – Dose Below MTD vs Optimal Biologic Dose (OBD) ⚖️ Traditional chemo used doses below MTD for short-term therapy 🧬 Targeted TKIs are long-term → chronic toxicities emerge 🎯 OBD= maintains efficacy with fewer side effects, better compliance & lower cost #TKI #Hematology

AhmedKo45911157's tweet image. 💊 #CML – Dose Below MTD vs Optimal Biologic Dose (OBD) ⚖️ Traditional chemo used doses below MTD for short-term therapy 🧬 Targeted TKIs are long-term → chronic toxicities emerge 🎯 OBD= maintains efficacy with fewer side effects, better compliance & lower cost #TKI #Hematology
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AlexeiCherubin's profile picture. @DalhousieU Alum :: Former Design Engineer :: Former Physics Teacher :: Content Creator (https://t.co/Kt5VyQ2k65) :: He/Him :: #NeverGiveUp
Alexei Cherubin
@AlexeiCherubin
Nov 12

The attached shows a simple OSPFv3 network. It's relatively simple. Designed for those now getting into the world of IPv6. It shows that there are 2 paths to any network. #cisco #ciscomodelinglabs #cml #IPV6 #OSPFv3

AlexeiCherubin's tweet image. The attached shows a simple OSPFv3 network. It's relatively simple. Designed for those now getting into the world of IPv6. It shows that there are 2 paths to any network. #cisco #ciscomodelinglabs #cml #IPV6 #OSPFv3
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AhmedKo45911157's profile picture. Adult hematology and bone marrow transplant
Ahmed Kotb
 @AhmedKo45911157
Nov 11

🧬 CML TKIs in 2025 ✅ Approved: Imatinib, Nilotinib, Dasatinib, Bosutinib, Ponatinib (T315I), Asciminib (STAMPi), Radotinib 🇰🇷 🧪 Investigational: Olverembatinib, ELVN-001 (ABL1-KDi), TGRX-678, TERN-701 (STAMPi) 🎯 STAMPi = Specifically Targets the ABL Myristoyl Pocket #CML #TKI

AhmedKo45911157's tweet image. 🧬 CML TKIs in 2025 ✅ Approved: Imatinib, Nilotinib, Dasatinib, Bosutinib, Ponatinib (T315I), Asciminib (STAMPi), Radotinib 🇰🇷 🧪 Investigational: Olverembatinib, ELVN-001 (ABL1-KDi), TGRX-678, TERN-701 (STAMPi) 🎯 STAMPi = Specifically Targets the ABL Myristoyl Pocket #CML #TKI
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AhmedKo45911157's profile picture. Adult hematology and bone marrow transplant
Ahmed Kotb
 @AhmedKo45911157
Nov 11

🧬 CML: Then vs Now TKIs transformed care: ⏳ Before 2000: Fatal course, poor prognosis, 10-yr OS ~10%, Rx = Allo-SCT / IFN-α ⚡ Today: Indolent disease, excellent prognosis, 10-yr OS ~85–92% 💊 Imatinib, Dasatinib, Nilotinib, Bosutinib, Asciminib #CML #Leukemia #TKI #Hematology

AhmedKo45911157's tweet image. 🧬 CML: Then vs Now TKIs transformed care: ⏳ Before 2000: Fatal course, poor prognosis, 10-yr OS ~10%, Rx = Allo-SCT / IFN-α ⚡ Today: Indolent disease, excellent prognosis, 10-yr OS ~85–92% 💊 Imatinib, Dasatinib, Nilotinib, Bosutinib, Asciminib #CML #Leukemia #TKI #Hematology
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FadiHaddad_MD's profile picture. Assistant Professor, Leukemia Department MD Anderson Cancer Center, Houston
Fadi Haddad, MD
 @FadiHaddad_MD
Nov 10

📢 Check our latest podcast with the @OncBrothers on the side effects of #CML treatment & how to manage them 💊 Dose reduction recommended before switching to a different treatment 🧑‍⚕️Always communicate with your doctor Watch the full episode below 👇 #leusm #leukemia

OncBrothers's profile picture. Practice changing discussions by community oncologists-Rohit Gosain @RoswellPark & Rahul Gosain @WilmotCancer. OwnViews/NoMedAdvice.COI https://t.co/cJOjp0RvQE
Oncology Brothers
@OncBrothers
Nov 10

ToxCheck: AEs for TKIs & how to manage them when treating CML w/ @FadiHaddad_MD + #DrOnyeeChan ✅ Imatinib ✅ Ponatinib & Asciminib ✅ Dasatinib, Bosutinib, Nilotinib Full 🗣️: ⭐️ oncbrothers.com/tki-toxcheck-2… ⭐️ Also on “Oncology Brothers” podcast #HemeTwitter @OncUpdates

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LearningatCisco's profile picture. Start here. Go anywhere. Learn with Cisco accelerates your success, including #CCNA #CCNP #CCIE #CCDE Specialist & #DevNet. Use #CiscoCert to join conversation.
Learn with Cisco
@LearningatCisco
Feb 14

Save 25% on #CML-Personal / -Personal Plus, now through February 14, 2025, 11:59 p.m. Pacific Time. Shop now 👉 cs.co/9009Ijoil #CML

LearningatCisco's tweet image. Save 25% on #CML-Personal / -Personal Plus, now through February 14, 2025, 11:59 p.m. Pacific Time. Shop now 👉 cs.co/9009Ijoil #CML
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nobullshit48's profile picture. Difendiamo i Nostri colori. Proteggiamo i Nostri valori. Sempre al fianco della S.S.Lazio: la Prima Squadra della Capitale!
NO BULLSHIT
 @nobullshit48
Nov 14, 2023

#14novembre #CML #CurvaNord12 14.11.1971 - 14.11.2023 una storia, una fede BUON COMPLEANNO CML

nobullshit48's tweet image. #14novembre #CML #CurvaNord12 14.11.1971 - 14.11.2023 una storia, una fede BUON COMPLEANNO CML
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FadiHaddad_MD's profile picture. Assistant Professor, Leukemia Department MD Anderson Cancer Center, Houston
Fadi Haddad, MD
 @FadiHaddad_MD
Sep 1

📢 Check out our latest publication & recommendations on the management of #CML during #pregnancy Our algorithm below summarizes best practices depending on trimester ⬇️ 🔹Imatinib & Nilotinib = safest 🔸Dasatinib & Bosutnib = contraindicated #leusm @OncoAlert @doctorpemm

FadiHaddad_MD's tweet image. 📢 Check out our latest publication & recommendations on the management of #CML during #pregnancy Our algorithm below summarizes best practices depending on trimester ⬇️ 🔹Imatinib & Nilotinib = safest 🔸Dasatinib & Bosutnib = contraindicated #leusm @OncoAlert @doctorpemm
doctorpemm's profile picture. Professor, Leukemia; Executive Director-Cancer Medicine for MDACC Cancer Network | Director #BPDCN Program | Co-Section Head, MPN #MPNSM ;Tweets:my own opinions
Naveen Pemmaraju, MD
 @doctorpemm
Aug 30

👉👉👉New paper alert 🚨 Led by Dr Fadi Haddad .@FadiHaddad_MD 📣 Management of Chronic Myeloid Leukemia During Pregnancy: Review of Evidence and Treatment Algorithm - Clinical Lymphoma, Myeloma and Leukemia clinical-lymphoma-myeloma-leukemia.com/article/S2152-… | #leusm #MPNSM #endcancer

doctorpemm's tweet image. 👉👉👉New paper alert 🚨 Led by Dr Fadi Haddad .@FadiHaddad_MD 📣 Management of Chronic Myeloid Leukemia During Pregnancy: Review of Evidence and Treatment Algorithm - Clinical Lymphoma, Myeloma and Leukemia clinical-lymphoma-myeloma-leukemia.com/article/S2152-… | #leusm #MPNSM #endcancer
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smbenlazar's profile picture. Professor of hematology, Universitary hospital of Sidi Bel Abbés. Head, Hospitalisation and Geriatric Unit.
Benlazar S M A
 @smbenlazar
Nov 8, 2024

Decitabine, venetoclax, and ponatinib for advanced phase chronic myeloid leukaemia and Philadelphia chromosome-positive acute myeloid leukaemia: a single-arm, single-centre phase 2 trial - The Lancet Haematology thelancet.com/journals/lanha… #CML #leusm

smbenlazar's tweet image. Decitabine, venetoclax, and ponatinib for advanced phase chronic myeloid leukaemia and Philadelphia chromosome-positive acute myeloid leukaemia: a single-arm, single-centre phase 2 trial - The Lancet Haematology thelancet.com/journals/lanha… #CML #leusm
smbenlazar's tweet image. Decitabine, venetoclax, and ponatinib for advanced phase chronic myeloid leukaemia and Philadelphia chromosome-positive acute myeloid leukaemia: a single-arm, single-centre phase 2 trial - The Lancet Haematology thelancet.com/journals/lanha… #CML #leusm
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LearningatCisco's profile picture. Start here. Go anywhere. Learn with Cisco accelerates your success, including #CCNA #CCNP #CCIE #CCDE Specialist & #DevNet. Use #CiscoCert to join conversation.
Learn with Cisco
@LearningatCisco
Dec 2

Hurry, time is running out to SAVE 40% on #CML. 💸 Shop now: cs.co/6019tLTRL

LearningatCisco's tweet image. Hurry, time is running out to SAVE 40% on #CML. 💸 Shop now: cs.co/6019tLTRL
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aphotomama's profile picture. I speak in pictures.🦄🌊. Views expressed are my own #IronBoomerang ♏️ #ResistanceIsMyMiddleName https://t.co/ULRBURUEQd
Lädy Ä
 @aphotomama
Jul 3

I’m beyond relieved that 18 is winning the fight so far, but my god my heart hurts seeing these brochures around the house. #fuckcancer #CML

aphotomama's tweet image. I’m beyond relieved that 18 is winning the fight so far, but my god my heart hurts seeing these brochures around the house. #fuckcancer #CML
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SSLazioSweden's profile picture. Uppdateringar om Lazio, samlingar, pod via https://t.co/0h6FJ6ZE07 Merchkampanjer kör vi då och då 🦅
SS Lazio Sweden
 @SSLazioSweden
Nov 15, 2024

Vi i Laziali Svedesi vill bara önska CML 74 ett stort grattis på 53 år som grupp! Ni har inspirerat många av oss! Auguri Comandos Monteverde Lazio! 🦅🩵🫡 #CML #LazialiSvedesi #CML74 #Monteverde #SSLazio

SSLazioSweden's tweet image. Vi i Laziali Svedesi vill bara önska CML 74 ett stort grattis på 53 år som grupp! Ni har inspirerat många av oss! Auguri Comandos Monteverde Lazio! 🦅🩵🫡 #CML #LazialiSvedesi #CML74 #Monteverde #SSLazio
SSLazioSweden's tweet image. Vi i Laziali Svedesi vill bara önska CML 74 ett stort grattis på 53 år som grupp! Ni har inspirerat många av oss! Auguri Comandos Monteverde Lazio! 🦅🩵🫡 #CML #LazialiSvedesi #CML74 #Monteverde #SSLazio
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AhmedKo45911157's profile picture. Adult hematology and bone marrow transplant
Ahmed Kotb
 @AhmedKo45911157
Oct 25

🎯 Baseline TKI Selection in CML ✅ Therapy aim: Survival & durable DMR/TFR 👤 Age/comorbidities: Guide TKI tolerance 📊 Risk profile: Higher risk → consider 2G TKIs 💰 Cost: Impacts choice 🧬 2G TKIs = faster DMR; Imatinib → switch if resistance #CML #TKI

AhmedKo45911157's tweet image. 🎯 Baseline TKI Selection in CML ✅ Therapy aim: Survival & durable DMR/TFR 👤 Age/comorbidities: Guide TKI tolerance 📊 Risk profile: Higher risk → consider 2G TKIs 💰 Cost: Impacts choice 🧬 2G TKIs = faster DMR; Imatinib → switch if resistance #CML #TKI
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smbenlazar's profile picture. Professor of hematology, Universitary hospital of Sidi Bel Abbés. Head, Hospitalisation and Geriatric Unit.
Benlazar S M A
 @smbenlazar
Mar 25, 2024

Rapid and Deep Remission Induced by Blinatumomab for CD19-Positive Chronic Myeloid Leukemia in Lymphoid Blast Phase | JCO Precision Oncology ascopubs.org/doi/10.1200/PO… #CML

smbenlazar's tweet image. Rapid and Deep Remission Induced by Blinatumomab for CD19-Positive Chronic Myeloid Leukemia in Lymphoid Blast Phase | JCO Precision Oncology ascopubs.org/doi/10.1200/PO… #CML
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smbenlazar's profile picture. Professor of hematology, Universitary hospital of Sidi Bel Abbés. Head, Hospitalisation and Geriatric Unit.
Benlazar S M A
 @smbenlazar
Oct 7, 2024

Efficacy and safety of olverembatinib in adult BCR::ABL1-positive ALL with T315I mutation or relapsed/refractory disease |British Journal of Haematology | Wiley Online Library onlinelibrary.wiley.com/doi/full/10.11… #CML #leusm

smbenlazar's tweet image. Efficacy and safety of olverembatinib in adult BCR::ABL1-positive ALL with T315I mutation or relapsed/refractory disease |British Journal of Haematology | Wiley Online Library onlinelibrary.wiley.com/doi/full/10.11… #CML #leusm
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rullo_lulic_89's profile picture.
rullo_lulic_89
 @rullo_lulic_89
Nov 14

14/11/1971 - 14/11/2025 Auguri 𝗖𝗼𝗺𝗺𝗮𝗻𝗱𝗼𝘀 𝗠𝗼𝗻𝘁𝗲𝘃𝗲𝗿𝗱𝗲 𝗟𝗮𝘇𝗶𝗼 🤍💙🦅 #CML #CML74

rullo_lulic_89's tweet image. 14/11/1971 - 14/11/2025 Auguri 𝗖𝗼𝗺𝗺𝗮𝗻𝗱𝗼𝘀 𝗠𝗼𝗻𝘁𝗲𝘃𝗲𝗿𝗱𝗲 𝗟𝗮𝘇𝗶𝗼 🤍💙🦅 #CML #CML74
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JACCJournals's profile picture. Official account representing the ACC's #JACCJournals, one of the most widely read & most impactful CV journal programs in the world. @ACCinTouch #JACC
JACC Journals
 @JACCJournals
Oct 29

#CVD & risk factors are frequent in #CML BCR::ABL1 #TKIs have transformed survival, yet bring distinct CV challenges. Early CV risk assessment, careful TKI selection, & proactive prevention are essential. 🔗 jacc.org/doi/10.1016/j.… #JACCCardioOnc #CardioOnc #leusm

JACCJournals's tweet image. #CVD & risk factors are frequent in #CML BCR::ABL1 #TKIs have transformed survival, yet bring distinct CV challenges. Early CV risk assessment, careful TKI selection, & proactive prevention are essential. 🔗 jacc.org/doi/10.1016/j.… #JACCCardioOnc #CardioOnc #leusm
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F3_Olive's profile picture. Live life, own every second and never, never take anything for granted! https://t.co/WcfVyjLDkS
Greg Latini
 @F3_Olive
Apr 20, 2024

Should be your sweet 16th! #cml #onedaycloser

F3_Olive's tweet image. Should be your sweet 16th! #cml #onedaycloser
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christinemphmd's profile picture. Thoracic Medical Oncologist @WeillCornell @NYPHospital @WCMLungCancer, PD @WCMHemOncFellow, Spouse, Mom, Sheltie Parent, Food enthusiast. Tweets are mine.
Christine A. Garcia, MD, MPH
 @christinemphmd
Jan 24, 2024

We were honored to have Dr. Rüdiger Hehlmann, esteemed 2024 Richard T. Silver Visiting Professor, present at @WCMDeptofMed #GrandRounds this morning on #CML. He also took part in the @WCMHemOncFellow's case conference and lunch. Thanks for your visit! #MedEd @WCMSilverMPNCtr

christinemphmd's tweet image. We were honored to have Dr. Rüdiger Hehlmann, esteemed 2024 Richard T. Silver Visiting Professor, present at @WCMDeptofMed #GrandRounds this morning on #CML. He also took part in the @WCMHemOncFellow's case conference and lunch. Thanks for your visit! #MedEd @WCMSilverMPNCtr
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FadiHaddad_MD's profile picture. Assistant Professor, Leukemia Department MD Anderson Cancer Center, Houston
Fadi Haddad, MD
 @FadiHaddad_MD
Sep 4

Great overview by @GCC_Cortes at #SOHO25 on the treatment landscape of #CML 🔹Choosing the best frontline therapy depends on cost 💲, goal of treatment (survival versus TFR), & tolerability ‼️The presence of ASXL1 is adverse, even with asciminib @SocietyofHemOnc @OncoAlert

FadiHaddad_MD's tweet image. Great overview by @GCC_Cortes at #SOHO25 on the treatment landscape of #CML 🔹Choosing the best frontline therapy depends on cost 💲, goal of treatment (survival versus TFR), & tolerability ‼️The presence of ASXL1 is adverse, even with asciminib @SocietyofHemOnc @OncoAlert
FadiHaddad_MD's tweet image. Great overview by @GCC_Cortes at #SOHO25 on the treatment landscape of #CML 🔹Choosing the best frontline therapy depends on cost 💲, goal of treatment (survival versus TFR), & tolerability ‼️The presence of ASXL1 is adverse, even with asciminib @SocietyofHemOnc @OncoAlert
FadiHaddad_MD's tweet image. Great overview by @GCC_Cortes at #SOHO25 on the treatment landscape of #CML 🔹Choosing the best frontline therapy depends on cost 💲, goal of treatment (survival versus TFR), & tolerability ‼️The presence of ASXL1 is adverse, even with asciminib @SocietyofHemOnc @OncoAlert
FadiHaddad_MD's tweet image. Great overview by @GCC_Cortes at #SOHO25 on the treatment landscape of #CML 🔹Choosing the best frontline therapy depends on cost 💲, goal of treatment (survival versus TFR), & tolerability ‼️The presence of ASXL1 is adverse, even with asciminib @SocietyofHemOnc @OncoAlert
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HelgasonLab's profile picture. A leukaemia research group based in the Tommy Burns Laboratory at the Wolfson Wohl Cancer Research Centre, @UofGCancerSci @UofGlasgow. Headed by @VignirHelgason
Helgason Lab
 @HelgasonLab
Dec 11, 2023

Check out @Martha_Z ‘s 2nd #ASH2023 Abstract Achievement Award poster nr 2704!!! #macrophages #CML

HelgasonLab's tweet image. Check out @Martha_Z ‘s 2nd #ASH2023 Abstract Achievement Award poster nr 2704!!! #macrophages #CML
HelgasonLab's tweet image. Check out @Martha_Z ‘s 2nd #ASH2023 Abstract Achievement Award poster nr 2704!!! #macrophages #CML
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LearningatCisco's profile picture. Start here. Go anywhere. Learn with Cisco accelerates your success, including #CCNA #CCNP #CCIE #CCDE Specialist & #DevNet. Use #CiscoCert to join conversation.
Learn with Cisco
@LearningatCisco
Nov 12

📣 SALE ON #CML! Save 25% on Cisco Modeling Labs – Personal or Personal Plus until November 13, 2025, at 11:59 p.m. Pacific Time. Shop now: cs.co/60147neaa

LearningatCisco's tweet image. 📣 SALE ON #CML! Save 25% on Cisco Modeling Labs – Personal or Personal Plus until November 13, 2025, at 11:59 p.m. Pacific Time. Shop now: cs.co/60147neaa
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TalhaBadarMD's profile picture. Faculty @MayoCancerCare Alumni @MDAndersonNews Specialised in treating leukemia & myeloid disorder. Interest in #ALL, #TP53m MN #clonal_hematopoiesis
Talha Badar
 @TalhaBadarMD
Jun 1

#ASCO25 #CML “best choice of frontline TKI for CML” educational session, presented by Dr. Timothy Hughes. 1. No TKI is best for every pts, choice should be individualized based on pt profile. 2. Asciminib may be a better choice for younger pt looking for TFR, except for ASXL1,…

TalhaBadarMD's tweet image. #ASCO25 #CML “best choice of frontline TKI for CML” educational session, presented by Dr. Timothy Hughes. 1. No TKI is best for every pts, choice should be individualized based on pt profile. 2. Asciminib may be a better choice for younger pt looking for TFR, except for ASXL1,…
TalhaBadarMD's tweet image. #ASCO25 #CML “best choice of frontline TKI for CML” educational session, presented by Dr. Timothy Hughes. 1. No TKI is best for every pts, choice should be individualized based on pt profile. 2. Asciminib may be a better choice for younger pt looking for TFR, except for ASXL1,…
TalhaBadarMD's tweet image. #ASCO25 #CML “best choice of frontline TKI for CML” educational session, presented by Dr. Timothy Hughes. 1. No TKI is best for every pts, choice should be individualized based on pt profile. 2. Asciminib may be a better choice for younger pt looking for TFR, except for ASXL1,…
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AhmedKo45911157's profile picture. Adult hematology and bone marrow transplant
Ahmed Kotb
 @AhmedKo45911157
Nov 11

🧬 CML: Then vs Now TKIs transformed care: ⏳ Before 2000: Fatal course, poor prognosis, 10-yr OS ~10%, Rx = Allo-SCT / IFN-α ⚡ Today: Indolent disease, excellent prognosis, 10-yr OS ~85–92% 💊 Imatinib, Dasatinib, Nilotinib, Bosutinib, Asciminib #CML #Leukemia #TKI #Hematology

AhmedKo45911157's tweet image. 🧬 CML: Then vs Now TKIs transformed care: ⏳ Before 2000: Fatal course, poor prognosis, 10-yr OS ~10%, Rx = Allo-SCT / IFN-α ⚡ Today: Indolent disease, excellent prognosis, 10-yr OS ~85–92% 💊 Imatinib, Dasatinib, Nilotinib, Bosutinib, Asciminib #CML #Leukemia #TKI #Hematology
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