#cppplu search results

#CPPPLU Highlights: The HOPE trial @JAMA_current found IV alteplase 4.5–24h post-stroke ⏱️⚡ improved functional independence 🚶 (40% vs 26%) in patients with salvageable 🧠 tissue, despite ⬆️ sICH (3.8% vs 0.5%). #PharmICU loom.ly/fYyJw-k

#CPPPLU Highlights A RCT from @JAMA_current evaluated intra-arterial TNK after endovascular therapy on mRS scores at 90-days. The intra-arterial TNK group had ⬆️ likelihood of excellent outcomes without ⬆️ ICH 🩸 or mortality ⚰️. loom.ly/U9aOMlw #PharmICU

The October #CPPPLU contains updates on a wide variety of topics pertaining to thrombolytics in acute ischemic stroke 🧠, ICU delirium, fluid resuscitation in sepsis 🚰, and more! Check it out on SCCM Connect here: connect.sccm.org/discussion/oct… #PharmICU

#CPPPLU Highlights: Trial in @of_AIC looked at the risk of MAKE when holding immunosuppressive agents in renal txp patients admitted to the ICU. Findings suggest possible association with holding MPA during sepsis and worse clinical outcomes. #PharmICU loom.ly/Yuh-aY4

#CPPPLU Highlights. When further stratified by norepinephrine equivalent doses at time of angiotensin initiation, the association with mortality remained true for some, but not all, dose ranges. #PharmICU

#CPPPLU Highlights: In a retrospective study from @of_AIC, angiotensin II was associated with decreased 30d mortality in med-surg patients when added to conventional vasopressors. #PharmICU loom.ly/fYsU7Ak

#CPPPLU Highlights: A recent meta-analysis in @JACCJournals found net clinical benefit (↓ischemic stroke & systemic embolism but ↑ recurrent ICH) in ICH survivors with AF with resumption of oral AC compared to no oral AC. #PharmICU loom.ly/ON0iUaY

#CPPPLU Highlights: A recent RCT in @JCVAonline showed a reduction in post-op delirium by day 7 in patients undergoing off-pump coronary artery bypass grafting surgery when given esketamine (13.4% esketamine vs. 28.4% placebo, p=0.034) #PharmICU loom.ly/mCRTeXA

#CPPPLU Highlights: This recent trial from @NEJM evaluated lactated ringer’s or normal saline for routine IV fluid administration. There was no difference in death, hospital readmission, or dialysis initiation within 90 days. #PharmICU loom.ly/CPRnAH0

#CPPPLU Highlights: The DEFENDER trial from @_Anesthesiology found that perioperative nitric oxide reduced acute kidney injury in patients with chronic kidney disease undergoing elective cardiac surgery with bypass (23.5% vs 39.7%, p=0.043). #PharmICU loom.ly/jHKlfc4

#CPPPLU Highlights: Recent SMRA from @JCVAonline evaluated RAS-Inhibitor D/C prior to non-cardiac surgery. Increase in intraop hypotension seen with RAS-I continuation prior to surgery but no differences in other clinical outcomes including MACE. #PharmICU loom.ly/wFGbHpE

#CPPPLU Highlights: A recent randomized trial published in @jama_current found no difference in hospital days free and days alive at 90 days in critically ill patients who received augmented protein (100 g/L) or usual protein (63 g/L). #PharmICU loom.ly/a2PztPo

#CPPPLU Highlights. Which crystalloid is best? This RCT in @accpchest found no difference in bicarb concentration, mortality, or organ failure with LR vs Normasol-R. loom.ly/Jf-orRc #PharmICU @EdQian @KarenEJacksonMD @JoannaCCPharmD @JonathanCaseyMD @toddricee_ICU

The October #CPPPLU contains updates on a wide variety of topics pertaining to thrombolytics in acute ischemic stroke 🧠, ICU delirium, fluid resuscitation in sepsis 🚰, and more! Check it out on SCCM Connect here: connect.sccm.org/discussion/oct… #PharmICU

#CPPPLU Highlights A RCT from @JAMA_current evaluated intra-arterial TNK after endovascular therapy on mRS scores at 90-days. The intra-arterial TNK group had ⬆️ likelihood of excellent outcomes without ⬆️ ICH 🩸 or mortality ⚰️. loom.ly/U9aOMlw #PharmICU

#CPPPLU Highlights: This recent study from @yourICM evaluated the use of sodium bicarbonate in critically ill patients with metabolic acidosis. Overall, they found a 1.9% absolute risk reduction in mortality. #PharmICU loom.ly/FW4wqX0

#CPPPLU Highlights. A recent study in @JCVAonline found that hydroxocobalamin was associated with a greater reduction in vasopressor requirements and ↑ in MAP compared to methylene blue for vasoplegic shock post-CPB. #PharmICU loom.ly/Mn2o-Vc

#CPPPLU Highlights: The DEFENDER trial from @_Anesthesiology found that perioperative nitric oxide reduced acute kidney injury in patients with chronic kidney disease undergoing elective cardiac surgery with bypass (23.5% vs 39.7%, p=0.043). #PharmICU loom.ly/jHKlfc4

#CPPPLU Highlights: The I-MICRO Trial in @ATSBlueEditor found the use of iloprost in septic shock patients with persistent hypoperfusion despite appropriate resuscitation did not ↓ SOFA scores within 7 days compared to placebo. #PharmICU loom.ly/kZjz6dQ

#CPPPLU Highlights New therapeutic goal for ICH patients: Both lowering SBP and maintaining its stability. Aiming for both reduction + consistency could improve outcomes in intracerebral hemorrhage @NeurocritCareJ 🧠 loom.ly/HpJRs_Q #PharmICU

#CPPPLU Highlights Real world data show andexanet is associated with higher odds of excellent/good hemostasis but increased thrombotic events vs PCC published in @CritCareMed @NG_Panos #PharmICU loom.ly/b8yK2V0

#CPPPLU Highlights: A recent randomized trial published in @jama_current found no difference in hospital days free and days alive at 90 days in critically ill patients who received augmented protein (100 g/L) or usual protein (63 g/L). #PharmICU loom.ly/a2PztPo

#CPPPLU Highlights: This recent trial from @NEJM evaluated lactated ringer’s or normal saline for routine IV fluid administration. There was no difference in death, hospital readmission, or dialysis initiation within 90 days. #PharmICU loom.ly/CPRnAH0

#CPPPLU Highlights: This recent trial from @yourICM found that ICU patients on low-dose ketamine infusions (0.1-0.3 mg/kg/hr) were at an increased risk of experiencing hallucinations within 30 days of ICU admit. #PharmICU loom.ly/8lQrbB4

#CPPPLU Highlights. Which crystalloid is best? This RCT in @accpchest found no difference in bicarb concentration, mortality, or organ failure with LR vs Normasol-R. loom.ly/Jf-orRc #PharmICU @EdQian @KarenEJacksonMD @JoannaCCPharmD @JonathanCaseyMD @toddricee_ICU

#CPPPLU Highlights. New @AnnalsofEM ACEP ED intubation policy: NIV cuts hypoxemia, ketamine/etomidate keep BP stable, fentanyl/propofol may worsen shock, and fluids don’t fix peri-intubation hypotension. #PharmICU Details 👉 loom.ly/A1c0r8o

#CPPPLU Highlights: This trial from J Intensive Care Med compared DEX to PHB as an adjunct to lorazepam for ETOH withdrawal syndrome treatment. PHB was linked to ↓ hospital and ICU LOS and ↓ intubation risk compared to DEX. #PharmICU loom.ly/Xq2Kl0E

#CPPPLU Highlights A recent study in @CritCareExplore found that administration of 30 mL/kg of crystalloid 💧 by 2-3 hours of septic shock presentation ⬇️ mortality and ⬇️ need for mechanical ventilation compared with other time points. #PharmICU loom.ly/qXx_8cI

#CPPPLU Highlights: The secondary analysis of the DEFENDER trial in @Crit_Care found dapagliflozin led to increased diuresis and reduced fluid accumulation in critically ill patients with acute organ dysfunction. #PharmICU loom.ly/M_dcvPE

#CPPPLU Highlights: A recent @NEJM trial found IV tenecteplase before endovascular thrombectomy improved odds of functional independence at 90 days vs thrombectomy alone. #PharmICU loom.ly/OE-7oWM

#CPPPLU Highlights: This study from @Crit_Care found epinephrine use in refractory shockable OHCA was negatively associated with achieving a favorable neurologic outcome and overall survival. #PharmICU loom.ly/26vuFM8

#CPPPLU Highlights: Recent SMRA from @JCVAonline evaluated RAS-Inhibitor D/C prior to non-cardiac surgery. Increase in intraop hypotension seen with RAS-I continuation prior to surgery but no differences in other clinical outcomes including MACE. #PharmICU loom.ly/wFGbHpE

The CPP Section’s September Pharmacotherapy Literature Update features 10 summaries of recent publications on topics like management of adult patients requiring endotracheal intubation, perioperative nitric oxide in non-cardiac surgery and angiotensin II. #PharmICU #CPPPLU