#disturbedflow search results
Mechano-vulnerability of #EndothelialCell in #Atherosclerosis 🤠 EVA1A, elevated by #DisturbedFlow-Twist1 axis, blocks EC #Autophagy & induces #Apoptosis Dr. Paul Evans & Jovana Serbanovic-Canic lab @atvbahajournals 2023 @ProfPaulEvans @jscanic ahajournals.org/doi/10.1161/AT…
Interleukin-1 signal mediates #DisturbedFlow #OscillatoryShearStress (1 dyn/cm2, 1 Hz @ibidiCells)-induced #EndMT #EndothelialCell IL-1RI immunreactivity⏫in👤🐭athero-prone aortic zone Congrats on this inaugural paper @MaAlfaidi @FrontCVMedicine 2023🥳 frontiersin.org/articles/10.33…
ALK5/TGFβR1 as an #EndothelialCell Mechanosensor & Direct force sensor #DisturbedFlow-induced #EndMT (& 🐭#atherosclerosis) is mediated by ALK5-SHC in a TGFβ-Independent manner😎 Another big hit from Dr. Ellie Tzima lab @ScienceAdvances 2021 @EllieTzima advances.sciencemag.org/content/7/28/e…
#DisturbedFlow->#EndothelialCell proatherogenic reprogramming +traits of #EndMT, #EHT, End-Mф transition (ex vivo proved)🤠 Luminal cells of🐭partial carotid ligation Single-cell RNAseq+ATACseq TF: STAT1, TEF, RELA, FOS/JUN, TEAD1 (#YAP👈), ETV3 cell.com/cell-reports/f…
#LaminarShear pushes VE-PTP (How?🤓) to downstream pole of #EndothelialCell, followed by endocytosis->⏫p-Tie2 Potentially explain how #DisturbedFlow⏫#VascularPermeability & #Atherosclerosis Dr. Donald McDonald & Dietmar Vestweber labs @EmboMolMed 2023 embopress.org/doi/full/10.15…
Negative feedback control of #DisturbedFlow-induced #EndothelialCell inflammation & 🐭#Atherosclerosis Oscillatory flow-> #Piezo1-> Adrenomedullin-> Gαs-coupled receptor CALCRL->cAMP-PKA⏬NF-κB Dr. Akiko Nakayama & Stefan Offermanns lab @JCI_insight 2020 insight.jci.org/articles/view/…
A remarkable mechanism for #DisturbedFlow disruption of #EndothelialCell Junction in #Atherosclerosis🤠 DF-activated GRK2-> ⏫phosphoSer721 #Vinculin-> a closed conformation of Vinculin-> ⏬VE-cad junction Dr. Jeng-Jiann Chiu lab #EHJ 2022 @ESC_Journals academic.oup.com/eurheartj/adva…
Interesting to note that LC3B in EC +72 h #DisturbedFlow is mostly lipidated (Fig. 4A) 🥸 Does this suggest that endothelium under #DisturbedFlow enter an Autophagy-dependent state? For Survival, Shear-sensing & Secretion? 🧐
Something went wrong.
Something went wrong.
United States Trends
- 1. #MerryChristmasJustin 3,146 posts
- 2. Danity Kane 2,185 posts
- 3. UConn 7,720 posts
- 4. Slept 20.1K posts
- 5. Boogie Fland N/A
- 6. #WWENXT 17.8K posts
- 7. Aundrea N/A
- 8. Lamar Wilkerson 1,520 posts
- 9. #bb27 N/A
- 10. Scottie Barnes 2,391 posts
- 11. Raptors 11.5K posts
- 12. #RHOSLC 4,514 posts
- 13. MSPs 2,101 posts
- 14. Todd Golden N/A
- 15. Cale Makar N/A
- 16. Keanu 3,122 posts
- 17. Jalen Brunson 3,823 posts
- 18. Gowdy 5,666 posts
- 19. #iubb 1,681 posts
- 20. Oilers 3,395 posts