#dynein search results
??? Is it just us or does anyone else think that our animation of #dynein walking on the microtubule looks like #Spot from @BostonDynamics here tinyurl.com/2hbuy5aw ????? #walkthewalk #3D #biology #education #natureinspiredtech
@zhang_lab @qinhuirao @Yale report impressive #cryoEM structures of the HUGE outer arm #dynein (OAD) assembly on the axoneme that drives rhythmic ciliary beating. nature.com/articles/s4159…
LIC1-CTD phosphorylation and Pin1 function regulate mitotic Golgi fragmentation. Kumari, @SivaramMVS et al. @unescorcb show that phosphorylation and Pin1 binding to the LIC1 subunit selectively regulate mitotic #dynein functions bit.ly/2XRR8o3 #CellDivision #mitosis
Gáspár, Bullock, Ephrussi et al. @embl reveal that sequential activity of #dynein and #kinesin-1 motors during oskar mRNA transport to the #Drosophila oocyte posterior is orchestrated by competition between two RNA-binding proteins, Egl and Staufen bit.ly/3Mp2HZ7
Tirumala, Redpath, Ananthanarayanan et al. show that cytoplasmic #dynein is activated in a stochastic manner when it encounters preformed dynactin–cargo complexes on #microtubules. hubs.la/Q02h1QSm0 @BE_IISc @UNSWMedicine
Kumari, @SivaramMVS et al. @unescorcb show that site-specific cdk1 phosphorylation of the #dynein LIC1 subunit, or subsequent engagement of the prolyl isomerase Pin1, forms separate dynein-adaptor-cargo complexes for distinct dynein functions in #mitosis bit.ly/2XRR8o3
#Dynein counteracts left-handed twist in the #anaphase spindle. From @LilaNeahring et al. @DumontLab @UCSF showing that torques within and outside the human spindle balance twist at anaphase. hubs.la/Q02BLbBx0 #Cytoskeleton #CellCycle #CellDivision #Mitosis
What regulates the transport of autophagosomes along the axon? @sydneycason & @ErikaHolzbaur show that mature axonal autophagosomes are transported by the #microtubule motor #dynein, activated by JIP3/4, & regulated by ARF6 & RAB10 bit.ly/3MrP5Nw #Neuroscience #autophagy
Image shows #kinetochore levels of #Dynactin in presence of Spindly mutants. d'Amico, @AndreaMusacchi1 @mpimoph et al. provide a structure-function analysis of Spindly, a #Dynein–Dynactin adaptor that functions at #kinetochores during #mitosis. bit.ly/3LhXC42
Our January cover shows an artistic representation of #dynein-2 motors (red) powering retrograde intraflagellar transport on axonemal #microtubules (green). From De-Castro et al (bit.ly/3q9Qhe5) Artwork by @MariaJDe_Castro JCB January Issue: bit.ly/3mvnUEF
Unsupervised image-based profiling identifies a functional cluster containing known components of the #dynein machinery and novel factors. From Wong et al. @CellBiol_MRCLMB @AstraZeneca: hubs.la/Q02nnhZL0 #Cytoskeleton #Genetics #Trafficking
In a new review, Bryony Braschi @genenames, Stephen M. King @uconnhealth and colleagues provide an updated consensus nomenclature for components of #dynein motors and their assembly factors. bit.ly/3FdCjMr #Genetics #Cytoskeleton #Cilia
Orienting the #spindle: Plk1 phosphorylates and negatively regulates NuMA in human cells, affecing #dynein cortical localization in metaphase and proper spindle orientation. New #mitosis work by @Sachin_mitosis and colleagues @iiscbangalore: life-science-alliance.org/content/1/6/e2…
Alexander Fellows, Andrew Carter et al @MRC_LMB show that individual #dynein motors can move the entire axon length during retrograde transport. In the anterograde direction, dynein & dynactin are transported separately, keeping them apart until required. hubs.la/Q02mfsKQ0
.@sydneyecason, @ErikaHolzbaur and colleagues show that sequential #dynein effectors regulate axonal autophagosome motility in a maturation-dependent pathway. bit.ly/3mCVvNs From our collection Cellular Neurobiology 2021: bit.ly/3nTHfiC #SfN21
#Dynein and dynactin move long-range but are delivered separately to the axon tip, say Alexander Fellows (@AlexFellows1) Andrew Carter (@Carter_Lab) et al. @MRC_LMB hubs.la/Q02mqYtp0 #cytoskeleton #neuroscience #trafficking
Image: conformational changes in SPINDLY control #DYNEIN activation at #kinetochores. In this Spotlight, João Barbosa, @claudio_sunkel & @CarlosConde_i3S discuss work (bit.ly/3LhXC42) from d'Amico, @AndreaMusacchi1 and colleagues bit.ly/3CbiYf7
Sequential #dynein effectors regulate axonal autophagosome motility in a maturation-dependent pathway, say @sydneyecason, @ErikaHolzbaur and colleagues. bit.ly/3tZAixL #Neuroscience #Organelles #Physiology #Trafficking #autophagy
RIP Ian Gibbons - Father of #Dynein Very proud and honoured to have had the chance to work with you. Andrew
#InMemoriam of Dr. Ian Gibbons, whose discovery of the motor protein dynein in the early 1960s, launched the study of microtubule-based molecular motors ow.ly/UL1w30iCMYr
Lund et al. reveal that coupling of neuropeptide-containing dense core vesicles undergoing axonal transport to #kinesin-1 & #dynein is mediated by an adaptor complex composed of Syd/dJIP3/4 and RUFY, controlled by Rab2, Arl8, & the Arl8 activator BORC. hubs.la/Q03ZQ_VJ0
Calling all #MotorsInQuarantine fans: Please join us for 1.5 days of science on motors and the cytoskeleton as we celebrate the career of @_robx. More info snd sign-up here: tinyurl.com/mechanochemist… #kinesin #dynein #myosin #microtubules #actin #cytoskeleton
#Dynein fans, we've got a wonderful #OpenAccess #review #article for you in #CYTOSKELETON! "Post‐LECA Origin and Diversification of an Axonemal Outer Arm Dynein Motor" . You'll find it here: onlinelibrary.wiley.com/doi/full/10.10…
MIKRO UND MAKRO 🩸🧬🦠🧫🧪🌍🪐 #Dynein The motor protein dynein transports cellular cargo along microtubules pdb101.rcsb.org/motm/176
Zang et al. reveal CCSer2 as a Ndel1 binding protein that regulates #dynein activity at the cell periphery. Loss of CCSer2 disrupts #centrosome positioning & early #endosome trafficking, causing migration defects in developing #zebrafish & cell culture hubs.la/Q03jnWwj0
NuMA is a mitotic adaptor protein that activates #dynein and connects it to #microtubule minus ends. New study from Sabina Colombo, Thomas Surrey and colleagues (Centre for Genomic Regulation): hubs.la/Q036bRFT0 #Cytoskeleton #Mitosis #CellDivision #Biophysics
Back to real #cilia, which harbour many structural heterogeneities with unknown functions... doi.org/10.1101/cshper… .Could these contribute to a curvature or state-dependent stiffness that can be regulated to enhance wave propagation? #CryoEM & #dynein experts help us search!🙏
As we now know, #cilia beating requires the distributed action of #dynein motors along the filament... Amazingly, a mathematician predicted this doi.org/10.1242/jeb.35… (1958) in @J_Exp_Biol before the discovery of dynein! A few years later Gibbons found it i in #tetrahymena
Another #FREE ACCESS REVIEW Article is available for all to read in #CYTOSKELETON @CytoskelJournal . Functional and structural significance of the inner-arm-#dynein subspecies d in ciliary motility. Find it here: onlinelibrary.wiley.com/doi/full/10.10… #cilia #cell #cellbiology
Human breast #cancer cell, i.e., #adenocarcinoma cell (MDA-MB-231), loses structural integrity and generates migratory cytoplasts. The micro-cytoplasts migrate using #dynein-generated forces in the #microtubule network, and are independent of #myosin contractility.
Two papers dissecting the stepping dynamics of #dynein using molecular tracking with #MINFLUX: In vivo: biorxiv.org/content/10.110… In vitro: biorxiv.org/content/10.110… #superresolution #SMLM
#Dynein counteracts left-handed twist in the #anaphase spindle. From @LilaNeahring et al. @DumontLab @UCSF showing that torques within and outside the human spindle balance twist at anaphase. hubs.la/Q02BLbBx0 #Cytoskeleton #CellCycle #CellDivision #Mitosis
MIKRO UND MAKRO 🩸🧬🦠🧫🧪🌍🪐 The motor protein #dynein transports cellular cargo along #microtubules August 2014, David Goodsell doi.org/10.2210/rcsb_p…
#Myosin and #Dynein fans, we've got another #openaccess #researchpaper for you! Myosin phosphatase targeting subunit1 controls localization and motility of Rab7-containing vesicles: Is myosin phosphatase a cytoplasmic dynein regulator? Find it here: onlinelibrary.wiley.com/doi/full/10.10…
@zhang_lab @qinhuirao @Yale report impressive #cryoEM structures of the HUGE outer arm #dynein (OAD) assembly on the axoneme that drives rhythmic ciliary beating. nature.com/articles/s4159…
My artwork for the paper about #Dynein cargo transportation on a buckled #Microtubules is now on the cover of ACS Applied Bio Materials! pubs.acs.org/toc/aabmcb/3/4 pubs.acs.org/doi/10.1021/ac…
Centrosome Positioning in Dictyostelium: Moving beyond Microtubule Tip Dynamics sci.fo/4q4 #Centrosome #Microtubule #Dynein #Kinesin
Distinct subcellular distribution of early and late #endosomes is driven by differential interaction with STIM1-#dynein and #kinesin-14 #KIFC1 #microtubule motors - work by @gserini et al @adhynamic group @fpoirccs embopress.org/doi/10.15252/e…
Another #FREE ACCESS REVIEW Article is available for all to read in #CYTOSKELETON @CytoskelJournal . Functional and structural significance of the inner-arm-#dynein subspecies d in ciliary motility. Find it here: onlinelibrary.wiley.com/doi/full/10.10… #cilia #cell #cellbiology
Our January cover shows an artistic representation of #dynein-2 motors (red) powering retrograde intraflagellar transport on axonemal #microtubules (green). From De-Castro et al (bit.ly/3q9Qhe5) Artwork by @MariaJDe_Castro JCB January Issue: bit.ly/3mvnUEF
👟Does #axonemal inner-arm #dynein-d wear spike shoes to step along the #microtubule track? Look into its crystal structure to find out ➡bit.ly/3K2bgso 🖊Genji Kurisu & team @osaka_univ_e #structuralbiology #cytoskeleton
van der Horst, @tajepps et al. show that #dynein, a #microtubule motor protein, carries the voltage-gated potassium channel Kv7.4 away from the cell membrane in vascular smooth muscle cells, thereby reducing its functional impact bit.ly/2MOiOnZ #IntercellularSignaling
Mutations in the coiled-coil stalk of #dynein demonstrate its essential role in regulating #microtubule-dependent motor activity and coordinating conformational changes in the #ATPase motor domain - paper by Niekamp et al @BhabhaEkiertLab @SkirballNYUSoM emboj.embopress.org/content/early/…
This new year couldn't start any better. Our latest work (bit.ly/3q9Qhe5) featured on the cover and hilighted in the January issue @JCellBiol. Artistic representation of #IFT #dynein by @MariaJDe_Castro. Welcome 2022!
.@sydneyecason, @ErikaHolzbaur and colleagues show that sequential #dynein effectors regulate axonal autophagosome motility in a maturation-dependent pathway. bit.ly/3mCVvNs From our collection Cellular Neurobiology 2021: bit.ly/3nTHfiC #SfN21
Tirumala, Redpath, Ananthanarayanan et al. show that cytoplasmic #dynein is activated in a stochastic manner when it encounters preformed dynactin–cargo complexes on #microtubules. hubs.la/Q02h1QSm0 @BE_IISc @UNSWMedicine
Orienting the #spindle: Plk1 phosphorylates and negatively regulates NuMA in human cells, affecing #dynein cortical localization in metaphase and proper spindle orientation. New #mitosis work by @Sachin_mitosis and colleagues @iiscbangalore: life-science-alliance.org/content/1/6/e2…
#Retrograde #dynein-dependent transport of #ALS-associated #CRMP4 from axon to soma cause selective loss of #motoneurons in diverse patient-/mouse-derived cellular models of Amyotrophic Lateral Sclerosis @LabPerlson @TelAvivUni and collaborators embopress.org/doi/10.15252/e…
Studying #acentrosomal human cells, Daiju Kitagawa and coworkers define #NuMA/#dynein-mediated mechanisms of #mitotic #spindle bipolarization that may act redundantly with canonical #centrosomal pathways embopress.org/doi/10.15252/e…
🌟Editor's Choice🌟 #Axonemal inner-arm #dynein-d: how does it interact with #microtubules? The crystal structure of its stalk region provides clues ➡bit.ly/3K2bgso 🔎Read Commentary at ➡bit.ly/3PISrhj #structuralbiology
Sequential #dynein effectors regulate axonal autophagosome motility in a maturation-dependent pathway, say @sydneyecason, @ErikaHolzbaur and colleagues. bit.ly/3tZAixL #Neuroscience #Organelles #Physiology #Trafficking #autophagy
My #dynein partner-in-crime, Carol Cho, came by the lab today after a data collection trip at Diamond. 2009 vs 2018 photos...
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