#mariposa2 search results

Outstanding plenary presentation of the #MARIPOSA2 phase 3 trial by @APassaroMD, demonstrating the benefit of amivantamab/chemo (with or without lazertinib) over chemo in osi-refractory patients with EGFR-mutant NSCLC. #ESMO23

PTarantinoMD's tweet image. Outstanding plenary presentation of the #MARIPOSA2 phase 3 trial by @APassaroMD, demonstrating the benefit of amivantamab/chemo (with or without lazertinib) over chemo in osi-refractory patients with EGFR-mutant NSCLC. #ESMO23

Iqbal baik-baik di Paris ya🙂 #mariposa2 #lulukhf

redvelvetwenak's tweet image. Iqbal baik-baik di Paris ya🙂

#mariposa2 #lulukhf

Barbie Mariposa & the Fairy Princess #Mariposa2

ILoveBarbirTH's tweet image. Barbie Mariposa & the Fairy Princess #Mariposa2

Cuma iqbal jadi bucin aja bangga 😂 #Mariposa2 #wattpad

peeenpeen's tweet image. Cuma iqbal jadi bucin aja bangga 😂
#Mariposa2
#wattpad

6. #MARIPOSA2: Amivantamab + Laz + Chemo Vs Chemo Vs Ami + Chemo in 2L activating EGFR mNSCLC after Osi. - Improved PFS with Ami combo: 8.3mos (Ami/Laz/Chemo), 6.3mos (Ami/Chemo), 4.2mos (HR: 0.44 and 0.42) - Improved CNS PFS - Significant AEs with combo @APassaroMD 7/7

OncBrothers's tweet image. 6. #MARIPOSA2: Amivantamab + Laz + Chemo Vs Chemo Vs Ami + Chemo in 2L activating EGFR mNSCLC after Osi.

- Improved PFS with Ami combo: 8.3mos (Ami/Laz/Chemo), 6.3mos (Ami/Chemo), 4.2mos (HR: 0.44 and 0.42)
- Improved CNS PFS
- Significant AEs with combo
@APassaroMD 

7/7
OncBrothers's tweet image. 6. #MARIPOSA2: Amivantamab + Laz + Chemo Vs Chemo Vs Ami + Chemo in 2L activating EGFR mNSCLC after Osi.

- Improved PFS with Ami combo: 8.3mos (Ami/Laz/Chemo), 6.3mos (Ami/Chemo), 4.2mos (HR: 0.44 and 0.42)
- Improved CNS PFS
- Significant AEs with combo
@APassaroMD 

7/7
OncBrothers's tweet image. 6. #MARIPOSA2: Amivantamab + Laz + Chemo Vs Chemo Vs Ami + Chemo in 2L activating EGFR mNSCLC after Osi.

- Improved PFS with Ami combo: 8.3mos (Ami/Laz/Chemo), 6.3mos (Ami/Chemo), 4.2mos (HR: 0.44 and 0.42)
- Improved CNS PFS
- Significant AEs with combo
@APassaroMD 

7/7
OncBrothers's tweet image. 6. #MARIPOSA2: Amivantamab + Laz + Chemo Vs Chemo Vs Ami + Chemo in 2L activating EGFR mNSCLC after Osi.

- Improved PFS with Ami combo: 8.3mos (Ami/Laz/Chemo), 6.3mos (Ami/Chemo), 4.2mos (HR: 0.44 and 0.42)
- Improved CNS PFS
- Significant AEs with combo
@APassaroMD 

7/7

🔥🚨@OncoAlert Hot off the press Just published @Annals_Oncology in conjunction with presentation @myESMO #ESMO23 Results of #MARIPOSA2 trial of #Amivantamab +chemo with & without #Lazertinib in #EGFR+ advanced #NSCLC post progression on #Osimertinib 👇🏼 annalsofoncology.org/article/S0923-…

RManochakian's tweet image. 🔥🚨@OncoAlert Hot off the press
 
Just published @Annals_Oncology in conjunction with presentation @myESMO #ESMO23

Results of #MARIPOSA2 trial of
#Amivantamab +chemo with & without #Lazertinib in #EGFR+ advanced #NSCLC post progression on #Osimertinib
👇🏼
annalsofoncology.org/article/S0923-…


Getting great questions from patients with EGFR+ lung cancer about the #MARIPOSA and #MARIPOSA2 studies after #ELCC25, and how they differ. What else should we add to this table to make it more helpful? @EGFRResisters @jillfeldman4

lungoncdoc's tweet image. Getting great questions from patients with EGFR+ lung cancer about the #MARIPOSA and #MARIPOSA2 studies after #ELCC25, and how they differ. 

What else should we add to this table to make it more helpful? @EGFRResisters @jillfeldman4

And my favourite slide from #MARIPOSA2 study: huge heterogeneity of post-PD treatments in 3rd line. This underlines the vast heterogeneity of the disease and the need for options. #ESMO2024

s_couraud's tweet image. And my favourite slide from #MARIPOSA2 study: huge heterogeneity of post-PD treatments in 3rd line. This underlines the vast heterogeneity of the disease and the need for options.   
#ESMO2024

Nih ade nya dilan sebelas dua belas sama kakanya, mainannya ngilang #mariposa2

tiaraindahr's tweet image. Nih ade nya dilan sebelas dua belas sama kakanya, mainannya ngilang #mariposa2

oiya dari kemaren mau aploud ini lupa terus hihihi #mariposa2 @luluk_hf

fearlyyes's tweet image. oiya dari kemaren mau aploud ini lupa terus hihihi #mariposa2 @luluk_hf

1. #MARIPOSA2: Update, Ph III, 2L in mEGFR after Osimertinib, Amivantamab + Chemo vs Chemo: - Recently approved in Europe - mOS 17.7mos w/ Ami vs 15.3mos with chemo alone (HR 0.73), but ‘did NOT reach pre-specified significance’ - mPFS2 16mos vs 11.6mos (HR: 0.64) 2/9

OncBrothers's tweet image. 1. #MARIPOSA2: Update, Ph III, 2L in mEGFR after Osimertinib, Amivantamab + Chemo vs Chemo: 

- Recently approved in Europe
- mOS 17.7mos w/ Ami vs 15.3mos with chemo alone (HR 0.73), but ‘did NOT reach pre-specified significance’
- mPFS2 16mos vs 11.6mos (HR: 0.64)

2/9
OncBrothers's tweet image. 1. #MARIPOSA2: Update, Ph III, 2L in mEGFR after Osimertinib, Amivantamab + Chemo vs Chemo: 

- Recently approved in Europe
- mOS 17.7mos w/ Ami vs 15.3mos with chemo alone (HR 0.73), but ‘did NOT reach pre-specified significance’
- mPFS2 16mos vs 11.6mos (HR: 0.64)

2/9
OncBrothers's tweet image. 1. #MARIPOSA2: Update, Ph III, 2L in mEGFR after Osimertinib, Amivantamab + Chemo vs Chemo: 

- Recently approved in Europe
- mOS 17.7mos w/ Ami vs 15.3mos with chemo alone (HR 0.73), but ‘did NOT reach pre-specified significance’
- mPFS2 16mos vs 11.6mos (HR: 0.64)

2/9
OncBrothers's tweet image. 1. #MARIPOSA2: Update, Ph III, 2L in mEGFR after Osimertinib, Amivantamab + Chemo vs Chemo: 

- Recently approved in Europe
- mOS 17.7mos w/ Ami vs 15.3mos with chemo alone (HR 0.73), but ‘did NOT reach pre-specified significance’
- mPFS2 16mos vs 11.6mos (HR: 0.64)

2/9

Excellent points about Mariposa2 trial . It is a good option but toxic and we need to be selective @5_utr @Alfdoc2 @Larvol @OncoAlert @DrJNaidoo @myESMO #ESMO24

SuyogCancer's tweet image. Excellent points about Mariposa2 trial .
It is a good option but toxic and we need to be selective @5_utr @Alfdoc2 @Larvol @OncoAlert @DrJNaidoo @myESMO #ESMO24
SuyogCancer's tweet image. Excellent points about Mariposa2 trial .
It is a good option but toxic and we need to be selective @5_utr @Alfdoc2 @Larvol @OncoAlert @DrJNaidoo @myESMO #ESMO24
SuyogCancer's tweet image. Excellent points about Mariposa2 trial .
It is a good option but toxic and we need to be selective @5_utr @Alfdoc2 @Larvol @OncoAlert @DrJNaidoo @myESMO #ESMO24
SuyogCancer's tweet image. Excellent points about Mariposa2 trial .
It is a good option but toxic and we need to be selective @5_utr @Alfdoc2 @Larvol @OncoAlert @DrJNaidoo @myESMO #ESMO24


Updated @ASCO living guideline for Stage4 #NSCLC ŵ driver mutation Incorporates findings of #MARIPOSA and #MARIPOSA2: recommends consideration of Amivantamab in 1° and 2° #EGFR ex19 or L858R settings. Both studies improved PFS, OS immature ascopubs.org/doi/pdf/10.120…

MathewGWilson's tweet image. Updated @ASCO living guideline for Stage4 #NSCLC ŵ driver mutation 

Incorporates findings of #MARIPOSA and #MARIPOSA2: recommends consideration of Amivantamab in 1° and 2° #EGFR ex19 or L858R settings.  Both studies improved PFS, OS immature

ascopubs.org/doi/pdf/10.120…

#ESMO23 1> #lungcancer 1-15> (LBA15) Amivantamab Plus Chemotherapy (With or Without Lazertinib) vs Chemotherapy in EGFR-mutated Advanced NSCLC After Progression on Osimertinib: #MARIPOSA2, a Phase 3, Global, Randomized, Controlled Trial. #Osimertinib-resistant EGFR-mutant…

onco_park's tweet image. #ESMO23 
1> #lungcancer 
1-15> (LBA15) Amivantamab Plus Chemotherapy (With or Without Lazertinib) vs Chemotherapy in EGFR-mutated Advanced NSCLC After Progression on Osimertinib: #MARIPOSA2, a Phase 3, Global, Randomized, Controlled Trial.

#Osimertinib-resistant EGFR-mutant…

#ESMO23 💥 LAST Presidential3 @myESMO #MARIPOSA2 Amivantamab+Lazertinib+CT vs Amivantamab+CT vs CT #EGFRmut #NSCLC 📌 PFS 8.3 vs 6.3 vs 4.2m HR 0.48/0.44 📌 OS NS 📌 ORR 63 vs 64 vs 36% (OR 3.1) ☣️>G3 92% vs72% vs48% @ASCO @myESMO @_SEOM @OncoAlert @OncBrothers @weoncologists

DrMirallas's tweet image. #ESMO23
💥 LAST Presidential3 @myESMO 
#MARIPOSA2 Amivantamab+Lazertinib+CT vs Amivantamab+CT vs CT #EGFRmut #NSCLC 
📌 PFS 8.3 vs 6.3 vs 4.2m HR 0.48/0.44
📌 OS NS 
📌 ORR 63 vs 64 vs 36% (OR 3.1)
☣️>G3 92% vs72% vs48%
@ASCO @myESMO @_SEOM @OncoAlert @OncBrothers @weoncologists
DrMirallas's tweet image. #ESMO23
💥 LAST Presidential3 @myESMO 
#MARIPOSA2 Amivantamab+Lazertinib+CT vs Amivantamab+CT vs CT #EGFRmut #NSCLC 
📌 PFS 8.3 vs 6.3 vs 4.2m HR 0.48/0.44
📌 OS NS 
📌 ORR 63 vs 64 vs 36% (OR 3.1)
☣️>G3 92% vs72% vs48%
@ASCO @myESMO @_SEOM @OncoAlert @OncBrothers @weoncologists
DrMirallas's tweet image. #ESMO23
💥 LAST Presidential3 @myESMO 
#MARIPOSA2 Amivantamab+Lazertinib+CT vs Amivantamab+CT vs CT #EGFRmut #NSCLC 
📌 PFS 8.3 vs 6.3 vs 4.2m HR 0.48/0.44
📌 OS NS 
📌 ORR 63 vs 64 vs 36% (OR 3.1)
☣️>G3 92% vs72% vs48%
@ASCO @myESMO @_SEOM @OncoAlert @OncBrothers @weoncologists
DrMirallas's tweet image. #ESMO23
💥 LAST Presidential3 @myESMO 
#MARIPOSA2 Amivantamab+Lazertinib+CT vs Amivantamab+CT vs CT #EGFRmut #NSCLC 
📌 PFS 8.3 vs 6.3 vs 4.2m HR 0.48/0.44
📌 OS NS 
📌 ORR 63 vs 64 vs 36% (OR 3.1)
☣️>G3 92% vs72% vs48%
@ASCO @myESMO @_SEOM @OncoAlert @OncBrothers @weoncologists

UDAH BACA MARIPOSA 1 dari kak @lulukhf_stories ?? Kalo udah, Siap2 ikutan PO #Mariposa2 yaa.... Yang belum follow, follow dulu yak supaya ga ketinggalan info promo. Dan yang blm punya #Mariposa 1 bisa order di BukuWanita 😍😍 @coconutbooks_

BukuWanita's tweet image. UDAH BACA MARIPOSA 1 dari kak @lulukhf_stories ?? Kalo udah, Siap2 ikutan PO #Mariposa2 yaa....

Yang belum follow, follow dulu yak supaya ga ketinggalan info promo. 

Dan yang blm punya #Mariposa 1 bisa order di BukuWanita 😍😍
@coconutbooks_
BukuWanita's tweet image. UDAH BACA MARIPOSA 1 dari kak @lulukhf_stories ?? Kalo udah, Siap2 ikutan PO #Mariposa2 yaa....

Yang belum follow, follow dulu yak supaya ga ketinggalan info promo. 

Dan yang blm punya #Mariposa 1 bisa order di BukuWanita 😍😍
@coconutbooks_

#Amivantamab + Chemo now @US_FDA approved in 2L mEGFR NSCLC after Osimertinib based off #MARIPOSA2: - mOS 17.7mos w/ Ami vs 15.3mos with chemo alone (HR 0.73), but ‘did NOT reach pre-specified significance’ - mPFS2 16mos vs 11.6mos (HR: 0.64) #ESMO24 #OncTwitter #lcsm

OncBrothers's tweet image. #Amivantamab + Chemo now @US_FDA approved in 2L mEGFR NSCLC after Osimertinib based off #MARIPOSA2:

- mOS 17.7mos w/ Ami vs 15.3mos with chemo alone (HR 0.73), but ‘did NOT reach pre-specified significance’
- mPFS2 16mos vs 11.6mos (HR: 0.64)

#ESMO24 #OncTwitter #lcsm
OncBrothers's tweet image. #Amivantamab + Chemo now @US_FDA approved in 2L mEGFR NSCLC after Osimertinib based off #MARIPOSA2:

- mOS 17.7mos w/ Ami vs 15.3mos with chemo alone (HR 0.73), but ‘did NOT reach pre-specified significance’
- mPFS2 16mos vs 11.6mos (HR: 0.64)

#ESMO24 #OncTwitter #lcsm
OncBrothers's tweet image. #Amivantamab + Chemo now @US_FDA approved in 2L mEGFR NSCLC after Osimertinib based off #MARIPOSA2:

- mOS 17.7mos w/ Ami vs 15.3mos with chemo alone (HR 0.73), but ‘did NOT reach pre-specified significance’
- mPFS2 16mos vs 11.6mos (HR: 0.64)

#ESMO24 #OncTwitter #lcsm
OncBrothers's tweet image. #Amivantamab + Chemo now @US_FDA approved in 2L mEGFR NSCLC after Osimertinib based off #MARIPOSA2:

- mOS 17.7mos w/ Ami vs 15.3mos with chemo alone (HR 0.73), but ‘did NOT reach pre-specified significance’
- mPFS2 16mos vs 11.6mos (HR: 0.64)

#ESMO24 #OncTwitter #lcsm

‼️ @FDAOncology approves amivantamab + chemo for EGFR+ mNSCLC after TKI progression per phase 3 MARIPOSA-2 study: ▫️ PFS: 6.3 v 4.2 mos (HR 0.48) ▫️ ORR: 53% v 29% ▫️ No OS difference at interim (HR 0.73) ▫️ AEs: rash, IRR, nail toxicity, stomatitis @OncoAlert #lcsm

lungoncdoc's tweet image. ‼️ @FDAOncology approves amivantamab + chemo for EGFR+ mNSCLC after TKI progression per phase 3 MARIPOSA-2 study:

▫️ PFS: 6.3 v 4.2 mos (HR 0.48)
▫️ ORR: 53% v 29%
▫️ No OS difference at interim (HR 0.73)
▫️ AEs: rash, IRR, nail toxicity, stomatitis

@OncoAlert #lcsm


Great point!! Agree. Not all mutations are the same. Data from #ASCO25 regarding #MARIPOSA2 suggests it is a strong option regardless of baseline osi resistance mechanism.


As combination strategies move to the frontline for our patients, how do we integrate the #MARIPOSA2 regimen in our practice? @BalazsHalmosMD @OncBrothers @jillfeldman4


Getting great questions from patients with EGFR+ lung cancer about the #MARIPOSA and #MARIPOSA2 studies after #ELCC25, and how they differ. What else should we add to this table to make it more helpful? @EGFRResisters @jillfeldman4

lungoncdoc's tweet image. Getting great questions from patients with EGFR+ lung cancer about the #MARIPOSA and #MARIPOSA2 studies after #ELCC25, and how they differ. 

What else should we add to this table to make it more helpful? @EGFRResisters @jillfeldman4

Updated @ASCO living guideline for Stage4 #NSCLC ŵ driver mutation Incorporates findings of #MARIPOSA and #MARIPOSA2: recommends consideration of Amivantamab in 1° and 2° #EGFR ex19 or L858R settings. Both studies improved PFS, OS immature ascopubs.org/doi/pdf/10.120…

MathewGWilson's tweet image. Updated @ASCO living guideline for Stage4 #NSCLC ŵ driver mutation 

Incorporates findings of #MARIPOSA and #MARIPOSA2: recommends consideration of Amivantamab in 1° and 2° #EGFR ex19 or L858R settings.  Both studies improved PFS, OS immature

ascopubs.org/doi/pdf/10.120…

Sequencing therapies for patients is so important! As of 9/2024–Amivantamab plus chemotherapy has FDA approval after progression on oral osimertinib per #MARIPOSA2.


#Amivantamab + Chemo now @US_FDA approved in 2L mEGFR NSCLC after Osimertinib based off #MARIPOSA2: - mOS 17.7mos w/ Ami vs 15.3mos with chemo alone (HR 0.73), but ‘did NOT reach pre-specified significance’ - mPFS2 16mos vs 11.6mos (HR: 0.64) #ESMO24 #OncTwitter #lcsm

OncBrothers's tweet image. #Amivantamab + Chemo now @US_FDA approved in 2L mEGFR NSCLC after Osimertinib based off #MARIPOSA2:

- mOS 17.7mos w/ Ami vs 15.3mos with chemo alone (HR 0.73), but ‘did NOT reach pre-specified significance’
- mPFS2 16mos vs 11.6mos (HR: 0.64)

#ESMO24 #OncTwitter #lcsm
OncBrothers's tweet image. #Amivantamab + Chemo now @US_FDA approved in 2L mEGFR NSCLC after Osimertinib based off #MARIPOSA2:

- mOS 17.7mos w/ Ami vs 15.3mos with chemo alone (HR 0.73), but ‘did NOT reach pre-specified significance’
- mPFS2 16mos vs 11.6mos (HR: 0.64)

#ESMO24 #OncTwitter #lcsm
OncBrothers's tweet image. #Amivantamab + Chemo now @US_FDA approved in 2L mEGFR NSCLC after Osimertinib based off #MARIPOSA2:

- mOS 17.7mos w/ Ami vs 15.3mos with chemo alone (HR 0.73), but ‘did NOT reach pre-specified significance’
- mPFS2 16mos vs 11.6mos (HR: 0.64)

#ESMO24 #OncTwitter #lcsm
OncBrothers's tweet image. #Amivantamab + Chemo now @US_FDA approved in 2L mEGFR NSCLC after Osimertinib based off #MARIPOSA2:

- mOS 17.7mos w/ Ami vs 15.3mos with chemo alone (HR 0.73), but ‘did NOT reach pre-specified significance’
- mPFS2 16mos vs 11.6mos (HR: 0.64)

#ESMO24 #OncTwitter #lcsm

‼️ @FDAOncology approves amivantamab + chemo for EGFR+ mNSCLC after TKI progression per phase 3 MARIPOSA-2 study: ▫️ PFS: 6.3 v 4.2 mos (HR 0.48) ▫️ ORR: 53% v 29% ▫️ No OS difference at interim (HR 0.73) ▫️ AEs: rash, IRR, nail toxicity, stomatitis @OncoAlert #lcsm

lungoncdoc's tweet image. ‼️ @FDAOncology approves amivantamab + chemo for EGFR+ mNSCLC after TKI progression per phase 3 MARIPOSA-2 study:

▫️ PFS: 6.3 v 4.2 mos (HR 0.48)
▫️ ORR: 53% v 29%
▫️ No OS difference at interim (HR 0.73)
▫️ AEs: rash, IRR, nail toxicity, stomatitis

@OncoAlert #lcsm


1. #MARIPOSA2: Update, Ph III, 2L in mEGFR after Osimertinib, Amivantamab + Chemo vs Chemo: - Recently approved in Europe - mOS 17.7mos w/ Ami vs 15.3mos with chemo alone (HR 0.73), but ‘did NOT reach pre-specified significance’ - mPFS2 16mos vs 11.6mos (HR: 0.64) 2/9

OncBrothers's tweet image. 1. #MARIPOSA2: Update, Ph III, 2L in mEGFR after Osimertinib, Amivantamab + Chemo vs Chemo: 

- Recently approved in Europe
- mOS 17.7mos w/ Ami vs 15.3mos with chemo alone (HR 0.73), but ‘did NOT reach pre-specified significance’
- mPFS2 16mos vs 11.6mos (HR: 0.64)

2/9
OncBrothers's tweet image. 1. #MARIPOSA2: Update, Ph III, 2L in mEGFR after Osimertinib, Amivantamab + Chemo vs Chemo: 

- Recently approved in Europe
- mOS 17.7mos w/ Ami vs 15.3mos with chemo alone (HR 0.73), but ‘did NOT reach pre-specified significance’
- mPFS2 16mos vs 11.6mos (HR: 0.64)

2/9
OncBrothers's tweet image. 1. #MARIPOSA2: Update, Ph III, 2L in mEGFR after Osimertinib, Amivantamab + Chemo vs Chemo: 

- Recently approved in Europe
- mOS 17.7mos w/ Ami vs 15.3mos with chemo alone (HR 0.73), but ‘did NOT reach pre-specified significance’
- mPFS2 16mos vs 11.6mos (HR: 0.64)

2/9
OncBrothers's tweet image. 1. #MARIPOSA2: Update, Ph III, 2L in mEGFR after Osimertinib, Amivantamab + Chemo vs Chemo: 

- Recently approved in Europe
- mOS 17.7mos w/ Ami vs 15.3mos with chemo alone (HR 0.73), but ‘did NOT reach pre-specified significance’
- mPFS2 16mos vs 11.6mos (HR: 0.64)

2/9

Excellent points about Mariposa2 trial . It is a good option but toxic and we need to be selective @5_utr @Alfdoc2 @Larvol @OncoAlert @DrJNaidoo @myESMO #ESMO24

SuyogCancer's tweet image. Excellent points about Mariposa2 trial .
It is a good option but toxic and we need to be selective @5_utr @Alfdoc2 @Larvol @OncoAlert @DrJNaidoo @myESMO #ESMO24
SuyogCancer's tweet image. Excellent points about Mariposa2 trial .
It is a good option but toxic and we need to be selective @5_utr @Alfdoc2 @Larvol @OncoAlert @DrJNaidoo @myESMO #ESMO24
SuyogCancer's tweet image. Excellent points about Mariposa2 trial .
It is a good option but toxic and we need to be selective @5_utr @Alfdoc2 @Larvol @OncoAlert @DrJNaidoo @myESMO #ESMO24
SuyogCancer's tweet image. Excellent points about Mariposa2 trial .
It is a good option but toxic and we need to be selective @5_utr @Alfdoc2 @Larvol @OncoAlert @DrJNaidoo @myESMO #ESMO24


And my favourite slide from #MARIPOSA2 study: huge heterogeneity of post-PD treatments in 3rd line. This underlines the vast heterogeneity of the disease and the need for options. #ESMO2024

s_couraud's tweet image. And my favourite slide from #MARIPOSA2 study: huge heterogeneity of post-PD treatments in 3rd line. This underlines the vast heterogeneity of the disease and the need for options.   
#ESMO2024

@Rajatraj we have some data on that based off #MARIPOSA2 (Ami + Chemo or Ami + Laz + Chemo after upfront TKI). There is higher RR + PFS with Ami + Chemo +/- Laz vs Chemo. In most pts with progressive disease on Osi, I’ll likely add chemo and cont Osi or switch to Ami + Chemo.

OncBrothers's tweet image. @Rajatraj we have some data on that based off #MARIPOSA2 (Ami + Chemo or Ami + Laz + Chemo after upfront TKI). There is higher RR + PFS with Ami + Chemo +/- Laz vs Chemo. In most pts with progressive disease on Osi, I’ll likely add chemo and cont Osi or switch to Ami + Chemo.
OncBrothers's tweet image. @Rajatraj we have some data on that based off #MARIPOSA2 (Ami + Chemo or Ami + Laz + Chemo after upfront TKI). There is higher RR + PFS with Ami + Chemo +/- Laz vs Chemo. In most pts with progressive disease on Osi, I’ll likely add chemo and cont Osi or switch to Ami + Chemo.

L'amivantamab est disponible en accès précoce preAMM en deuxième ligne après échec d'un TKI et en association au carbo-pemetrexed, dans les mutations standards de l'EGFR. Une vraie avancée pour nos patients ! @HAS_sante @ansm @JanssenCilag #MARIPOSA2.


#ESMO23 💥 LAST Presidential3 @myESMO #MARIPOSA2 Amivantamab+Lazertinib+CT vs Amivantamab+CT vs CT #EGFRmut #NSCLC 📌 PFS 8.3 vs 6.3 vs 4.2m HR 0.48/0.44 📌 OS NS 📌 ORR 63 vs 64 vs 36% (OR 3.1) ☣️>G3 92% vs72% vs48% @ASCO @myESMO @_SEOM @OncoAlert @OncBrothers @weoncologists

DrMirallas's tweet image. #ESMO23
💥 LAST Presidential3 @myESMO 
#MARIPOSA2 Amivantamab+Lazertinib+CT vs Amivantamab+CT vs CT #EGFRmut #NSCLC 
📌 PFS 8.3 vs 6.3 vs 4.2m HR 0.48/0.44
📌 OS NS 
📌 ORR 63 vs 64 vs 36% (OR 3.1)
☣️>G3 92% vs72% vs48%
@ASCO @myESMO @_SEOM @OncoAlert @OncBrothers @weoncologists
DrMirallas's tweet image. #ESMO23
💥 LAST Presidential3 @myESMO 
#MARIPOSA2 Amivantamab+Lazertinib+CT vs Amivantamab+CT vs CT #EGFRmut #NSCLC 
📌 PFS 8.3 vs 6.3 vs 4.2m HR 0.48/0.44
📌 OS NS 
📌 ORR 63 vs 64 vs 36% (OR 3.1)
☣️>G3 92% vs72% vs48%
@ASCO @myESMO @_SEOM @OncoAlert @OncBrothers @weoncologists
DrMirallas's tweet image. #ESMO23
💥 LAST Presidential3 @myESMO 
#MARIPOSA2 Amivantamab+Lazertinib+CT vs Amivantamab+CT vs CT #EGFRmut #NSCLC 
📌 PFS 8.3 vs 6.3 vs 4.2m HR 0.48/0.44
📌 OS NS 
📌 ORR 63 vs 64 vs 36% (OR 3.1)
☣️>G3 92% vs72% vs48%
@ASCO @myESMO @_SEOM @OncoAlert @OncBrothers @weoncologists
DrMirallas's tweet image. #ESMO23
💥 LAST Presidential3 @myESMO 
#MARIPOSA2 Amivantamab+Lazertinib+CT vs Amivantamab+CT vs CT #EGFRmut #NSCLC 
📌 PFS 8.3 vs 6.3 vs 4.2m HR 0.48/0.44
📌 OS NS 
📌 ORR 63 vs 64 vs 36% (OR 3.1)
☣️>G3 92% vs72% vs48%
@ASCO @myESMO @_SEOM @OncoAlert @OncBrothers @weoncologists

Getting great questions from patients with EGFR+ lung cancer about the #MARIPOSA and #MARIPOSA2 studies after #ELCC25, and how they differ. What else should we add to this table to make it more helpful? @EGFRResisters @jillfeldman4

lungoncdoc's tweet image. Getting great questions from patients with EGFR+ lung cancer about the #MARIPOSA and #MARIPOSA2 studies after #ELCC25, and how they differ. 

What else should we add to this table to make it more helpful? @EGFRResisters @jillfeldman4

Barbie Mariposa & the Fairy Princess #Mariposa2

ILoveBarbirTH's tweet image. Barbie Mariposa & the Fairy Princess #Mariposa2

Cuma iqbal jadi bucin aja bangga 😂 #Mariposa2 #wattpad

peeenpeen's tweet image. Cuma iqbal jadi bucin aja bangga 😂
#Mariposa2
#wattpad

Iqbal baik-baik di Paris ya🙂 #mariposa2 #lulukhf

redvelvetwenak's tweet image. Iqbal baik-baik di Paris ya🙂

#mariposa2 #lulukhf

6. #MARIPOSA2: Amivantamab + Laz + Chemo Vs Chemo Vs Ami + Chemo in 2L activating EGFR mNSCLC after Osi. - Improved PFS with Ami combo: 8.3mos (Ami/Laz/Chemo), 6.3mos (Ami/Chemo), 4.2mos (HR: 0.44 and 0.42) - Improved CNS PFS - Significant AEs with combo @APassaroMD 7/7

OncBrothers's tweet image. 6. #MARIPOSA2: Amivantamab + Laz + Chemo Vs Chemo Vs Ami + Chemo in 2L activating EGFR mNSCLC after Osi.

- Improved PFS with Ami combo: 8.3mos (Ami/Laz/Chemo), 6.3mos (Ami/Chemo), 4.2mos (HR: 0.44 and 0.42)
- Improved CNS PFS
- Significant AEs with combo
@APassaroMD 

7/7
OncBrothers's tweet image. 6. #MARIPOSA2: Amivantamab + Laz + Chemo Vs Chemo Vs Ami + Chemo in 2L activating EGFR mNSCLC after Osi.

- Improved PFS with Ami combo: 8.3mos (Ami/Laz/Chemo), 6.3mos (Ami/Chemo), 4.2mos (HR: 0.44 and 0.42)
- Improved CNS PFS
- Significant AEs with combo
@APassaroMD 

7/7
OncBrothers's tweet image. 6. #MARIPOSA2: Amivantamab + Laz + Chemo Vs Chemo Vs Ami + Chemo in 2L activating EGFR mNSCLC after Osi.

- Improved PFS with Ami combo: 8.3mos (Ami/Laz/Chemo), 6.3mos (Ami/Chemo), 4.2mos (HR: 0.44 and 0.42)
- Improved CNS PFS
- Significant AEs with combo
@APassaroMD 

7/7
OncBrothers's tweet image. 6. #MARIPOSA2: Amivantamab + Laz + Chemo Vs Chemo Vs Ami + Chemo in 2L activating EGFR mNSCLC after Osi.

- Improved PFS with Ami combo: 8.3mos (Ami/Laz/Chemo), 6.3mos (Ami/Chemo), 4.2mos (HR: 0.44 and 0.42)
- Improved CNS PFS
- Significant AEs with combo
@APassaroMD 

7/7

🔥🚨@OncoAlert Hot off the press Just published @Annals_Oncology in conjunction with presentation @myESMO #ESMO23 Results of #MARIPOSA2 trial of #Amivantamab +chemo with & without #Lazertinib in #EGFR+ advanced #NSCLC post progression on #Osimertinib 👇🏼 annalsofoncology.org/article/S0923-…

RManochakian's tweet image. 🔥🚨@OncoAlert Hot off the press
 
Just published @Annals_Oncology in conjunction with presentation @myESMO #ESMO23

Results of #MARIPOSA2 trial of
#Amivantamab +chemo with & without #Lazertinib in #EGFR+ advanced #NSCLC post progression on #Osimertinib
👇🏼
annalsofoncology.org/article/S0923-…


#ESMO23 1> #lungcancer 1-15> (LBA15) Amivantamab Plus Chemotherapy (With or Without Lazertinib) vs Chemotherapy in EGFR-mutated Advanced NSCLC After Progression on Osimertinib: #MARIPOSA2, a Phase 3, Global, Randomized, Controlled Trial. #Osimertinib-resistant EGFR-mutant…

onco_park's tweet image. #ESMO23 
1> #lungcancer 
1-15> (LBA15) Amivantamab Plus Chemotherapy (With or Without Lazertinib) vs Chemotherapy in EGFR-mutated Advanced NSCLC After Progression on Osimertinib: #MARIPOSA2, a Phase 3, Global, Randomized, Controlled Trial.

#Osimertinib-resistant EGFR-mutant…

And my favourite slide from #MARIPOSA2 study: huge heterogeneity of post-PD treatments in 3rd line. This underlines the vast heterogeneity of the disease and the need for options. #ESMO2024

s_couraud's tweet image. And my favourite slide from #MARIPOSA2 study: huge heterogeneity of post-PD treatments in 3rd line. This underlines the vast heterogeneity of the disease and the need for options.   
#ESMO2024

#Amivantamab + Chemo now @US_FDA approved in 2L mEGFR NSCLC after Osimertinib based off #MARIPOSA2: - mOS 17.7mos w/ Ami vs 15.3mos with chemo alone (HR 0.73), but ‘did NOT reach pre-specified significance’ - mPFS2 16mos vs 11.6mos (HR: 0.64) #ESMO24 #OncTwitter #lcsm

OncBrothers's tweet image. #Amivantamab + Chemo now @US_FDA approved in 2L mEGFR NSCLC after Osimertinib based off #MARIPOSA2:

- mOS 17.7mos w/ Ami vs 15.3mos with chemo alone (HR 0.73), but ‘did NOT reach pre-specified significance’
- mPFS2 16mos vs 11.6mos (HR: 0.64)

#ESMO24 #OncTwitter #lcsm
OncBrothers's tweet image. #Amivantamab + Chemo now @US_FDA approved in 2L mEGFR NSCLC after Osimertinib based off #MARIPOSA2:

- mOS 17.7mos w/ Ami vs 15.3mos with chemo alone (HR 0.73), but ‘did NOT reach pre-specified significance’
- mPFS2 16mos vs 11.6mos (HR: 0.64)

#ESMO24 #OncTwitter #lcsm
OncBrothers's tweet image. #Amivantamab + Chemo now @US_FDA approved in 2L mEGFR NSCLC after Osimertinib based off #MARIPOSA2:

- mOS 17.7mos w/ Ami vs 15.3mos with chemo alone (HR 0.73), but ‘did NOT reach pre-specified significance’
- mPFS2 16mos vs 11.6mos (HR: 0.64)

#ESMO24 #OncTwitter #lcsm
OncBrothers's tweet image. #Amivantamab + Chemo now @US_FDA approved in 2L mEGFR NSCLC after Osimertinib based off #MARIPOSA2:

- mOS 17.7mos w/ Ami vs 15.3mos with chemo alone (HR 0.73), but ‘did NOT reach pre-specified significance’
- mPFS2 16mos vs 11.6mos (HR: 0.64)

#ESMO24 #OncTwitter #lcsm

‼️ @FDAOncology approves amivantamab + chemo for EGFR+ mNSCLC after TKI progression per phase 3 MARIPOSA-2 study: ▫️ PFS: 6.3 v 4.2 mos (HR 0.48) ▫️ ORR: 53% v 29% ▫️ No OS difference at interim (HR 0.73) ▫️ AEs: rash, IRR, nail toxicity, stomatitis @OncoAlert #lcsm

lungoncdoc's tweet image. ‼️ @FDAOncology approves amivantamab + chemo for EGFR+ mNSCLC after TKI progression per phase 3 MARIPOSA-2 study:

▫️ PFS: 6.3 v 4.2 mos (HR 0.48)
▫️ ORR: 53% v 29%
▫️ No OS difference at interim (HR 0.73)
▫️ AEs: rash, IRR, nail toxicity, stomatitis

@OncoAlert #lcsm


@Rajatraj we have some data on that based off #MARIPOSA2 (Ami + Chemo or Ami + Laz + Chemo after upfront TKI). There is higher RR + PFS with Ami + Chemo +/- Laz vs Chemo. In most pts with progressive disease on Osi, I’ll likely add chemo and cont Osi or switch to Ami + Chemo.

OncBrothers's tweet image. @Rajatraj we have some data on that based off #MARIPOSA2 (Ami + Chemo or Ami + Laz + Chemo after upfront TKI). There is higher RR + PFS with Ami + Chemo +/- Laz vs Chemo. In most pts with progressive disease on Osi, I’ll likely add chemo and cont Osi or switch to Ami + Chemo.
OncBrothers's tweet image. @Rajatraj we have some data on that based off #MARIPOSA2 (Ami + Chemo or Ami + Laz + Chemo after upfront TKI). There is higher RR + PFS with Ami + Chemo +/- Laz vs Chemo. In most pts with progressive disease on Osi, I’ll likely add chemo and cont Osi or switch to Ami + Chemo.

🔥🚨@OncoAlert Hot off the press Just published @Annals_Oncology in conjunction with presentation @myESMO #ESMO23 Results of #MARIPOSA2 trial of #Amivantamab +chemo with & without #Lazertinib in #EGFR+ advanced #NSCLC post progression on #Osimertinib 👇🏼 annalsofoncology.org/article/S0923-…

RManochakian's tweet image. 🔥🚨@OncoAlert Hot off the press
 
Just published @Annals_Oncology in conjunction with presentation @myESMO #ESMO23

Results of #MARIPOSA2 trial of
#Amivantamab +chemo with & without #Lazertinib in #EGFR+ advanced #NSCLC post progression on #Osimertinib
👇🏼
annalsofoncology.org/article/S0923-…

Outstanding plenary presentation of the #MARIPOSA2 phase 3 trial by @APassaroMD, demonstrating the benefit of amivantamab/chemo (with or without lazertinib) over chemo in osi-refractory patients with EGFR-mutant NSCLC. #ESMO23

PTarantinoMD's tweet image. Outstanding plenary presentation of the #MARIPOSA2 phase 3 trial by @APassaroMD, demonstrating the benefit of amivantamab/chemo (with or without lazertinib) over chemo in osi-refractory patients with EGFR-mutant NSCLC. #ESMO23

1. #MARIPOSA2: Update, Ph III, 2L in mEGFR after Osimertinib, Amivantamab + Chemo vs Chemo: - Recently approved in Europe - mOS 17.7mos w/ Ami vs 15.3mos with chemo alone (HR 0.73), but ‘did NOT reach pre-specified significance’ - mPFS2 16mos vs 11.6mos (HR: 0.64) 2/9

OncBrothers's tweet image. 1. #MARIPOSA2: Update, Ph III, 2L in mEGFR after Osimertinib, Amivantamab + Chemo vs Chemo: 

- Recently approved in Europe
- mOS 17.7mos w/ Ami vs 15.3mos with chemo alone (HR 0.73), but ‘did NOT reach pre-specified significance’
- mPFS2 16mos vs 11.6mos (HR: 0.64)

2/9
OncBrothers's tweet image. 1. #MARIPOSA2: Update, Ph III, 2L in mEGFR after Osimertinib, Amivantamab + Chemo vs Chemo: 

- Recently approved in Europe
- mOS 17.7mos w/ Ami vs 15.3mos with chemo alone (HR 0.73), but ‘did NOT reach pre-specified significance’
- mPFS2 16mos vs 11.6mos (HR: 0.64)

2/9
OncBrothers's tweet image. 1. #MARIPOSA2: Update, Ph III, 2L in mEGFR after Osimertinib, Amivantamab + Chemo vs Chemo: 

- Recently approved in Europe
- mOS 17.7mos w/ Ami vs 15.3mos with chemo alone (HR 0.73), but ‘did NOT reach pre-specified significance’
- mPFS2 16mos vs 11.6mos (HR: 0.64)

2/9
OncBrothers's tweet image. 1. #MARIPOSA2: Update, Ph III, 2L in mEGFR after Osimertinib, Amivantamab + Chemo vs Chemo: 

- Recently approved in Europe
- mOS 17.7mos w/ Ami vs 15.3mos with chemo alone (HR 0.73), but ‘did NOT reach pre-specified significance’
- mPFS2 16mos vs 11.6mos (HR: 0.64)

2/9

Excellent points about Mariposa2 trial . It is a good option but toxic and we need to be selective @5_utr @Alfdoc2 @Larvol @OncoAlert @DrJNaidoo @myESMO #ESMO24

SuyogCancer's tweet image. Excellent points about Mariposa2 trial .
It is a good option but toxic and we need to be selective @5_utr @Alfdoc2 @Larvol @OncoAlert @DrJNaidoo @myESMO #ESMO24
SuyogCancer's tweet image. Excellent points about Mariposa2 trial .
It is a good option but toxic and we need to be selective @5_utr @Alfdoc2 @Larvol @OncoAlert @DrJNaidoo @myESMO #ESMO24
SuyogCancer's tweet image. Excellent points about Mariposa2 trial .
It is a good option but toxic and we need to be selective @5_utr @Alfdoc2 @Larvol @OncoAlert @DrJNaidoo @myESMO #ESMO24
SuyogCancer's tweet image. Excellent points about Mariposa2 trial .
It is a good option but toxic and we need to be selective @5_utr @Alfdoc2 @Larvol @OncoAlert @DrJNaidoo @myESMO #ESMO24


Nih ade nya dilan sebelas dua belas sama kakanya, mainannya ngilang #mariposa2

tiaraindahr's tweet image. Nih ade nya dilan sebelas dua belas sama kakanya, mainannya ngilang #mariposa2

UDAH BACA MARIPOSA 1 dari kak @lulukhf_stories ?? Kalo udah, Siap2 ikutan PO #Mariposa2 yaa.... Yang belum follow, follow dulu yak supaya ga ketinggalan info promo. Dan yang blm punya #Mariposa 1 bisa order di BukuWanita 😍😍 @coconutbooks_

BukuWanita's tweet image. UDAH BACA MARIPOSA 1 dari kak @lulukhf_stories ?? Kalo udah, Siap2 ikutan PO #Mariposa2 yaa....

Yang belum follow, follow dulu yak supaya ga ketinggalan info promo. 

Dan yang blm punya #Mariposa 1 bisa order di BukuWanita 😍😍
@coconutbooks_
BukuWanita's tweet image. UDAH BACA MARIPOSA 1 dari kak @lulukhf_stories ?? Kalo udah, Siap2 ikutan PO #Mariposa2 yaa....

Yang belum follow, follow dulu yak supaya ga ketinggalan info promo. 

Dan yang blm punya #Mariposa 1 bisa order di BukuWanita 😍😍
@coconutbooks_

oiya dari kemaren mau aploud ini lupa terus hihihi #mariposa2 @luluk_hf

fearlyyes's tweet image. oiya dari kemaren mau aploud ini lupa terus hihihi #mariposa2 @luluk_hf

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