#mariposa2 search results
Outstanding plenary presentation of the #MARIPOSA2 phase 3 trial by @APassaroMD, demonstrating the benefit of amivantamab/chemo (with or without lazertinib) over chemo in osi-refractory patients with EGFR-mutant NSCLC. #ESMO23
6. #MARIPOSA2: Amivantamab + Laz + Chemo Vs Chemo Vs Ami + Chemo in 2L activating EGFR mNSCLC after Osi. - Improved PFS with Ami combo: 8.3mos (Ami/Laz/Chemo), 6.3mos (Ami/Chemo), 4.2mos (HR: 0.44 and 0.42) - Improved CNS PFS - Significant AEs with combo @APassaroMD 7/7
🔥🚨@OncoAlert Hot off the press Just published @Annals_Oncology in conjunction with presentation @myESMO #ESMO23 Results of #MARIPOSA2 trial of #Amivantamab +chemo with & without #Lazertinib in #EGFR+ advanced #NSCLC post progression on #Osimertinib 👇🏼 annalsofoncology.org/article/S0923-…
Getting great questions from patients with EGFR+ lung cancer about the #MARIPOSA and #MARIPOSA2 studies after #ELCC25, and how they differ. What else should we add to this table to make it more helpful? @EGFRResisters @jillfeldman4
And my favourite slide from #MARIPOSA2 study: huge heterogeneity of post-PD treatments in 3rd line. This underlines the vast heterogeneity of the disease and the need for options. #ESMO2024
1. #MARIPOSA2: Update, Ph III, 2L in mEGFR after Osimertinib, Amivantamab + Chemo vs Chemo: - Recently approved in Europe - mOS 17.7mos w/ Ami vs 15.3mos with chemo alone (HR 0.73), but ‘did NOT reach pre-specified significance’ - mPFS2 16mos vs 11.6mos (HR: 0.64) 2/9
Excellent points about Mariposa2 trial . It is a good option but toxic and we need to be selective @5_utr @Alfdoc2 @Larvol @OncoAlert @DrJNaidoo @myESMO #ESMO24
Updated @ASCO living guideline for Stage4 #NSCLC ŵ driver mutation Incorporates findings of #MARIPOSA and #MARIPOSA2: recommends consideration of Amivantamab in 1° and 2° #EGFR ex19 or L858R settings. Both studies improved PFS, OS immature ascopubs.org/doi/pdf/10.120…
#ESMO23 1> #lungcancer 1-15> (LBA15) Amivantamab Plus Chemotherapy (With or Without Lazertinib) vs Chemotherapy in EGFR-mutated Advanced NSCLC After Progression on Osimertinib: #MARIPOSA2, a Phase 3, Global, Randomized, Controlled Trial. #Osimertinib-resistant EGFR-mutant…
#ESMO23 💥 LAST Presidential3 @myESMO #MARIPOSA2 Amivantamab+Lazertinib+CT vs Amivantamab+CT vs CT #EGFRmut #NSCLC 📌 PFS 8.3 vs 6.3 vs 4.2m HR 0.48/0.44 📌 OS NS 📌 ORR 63 vs 64 vs 36% (OR 3.1) ☣️>G3 92% vs72% vs48% @ASCO @myESMO @_SEOM @OncoAlert @OncBrothers @weoncologists
UDAH BACA MARIPOSA 1 dari kak @lulukhf_stories ?? Kalo udah, Siap2 ikutan PO #Mariposa2 yaa.... Yang belum follow, follow dulu yak supaya ga ketinggalan info promo. Dan yang blm punya #Mariposa 1 bisa order di BukuWanita 😍😍 @coconutbooks_
#Amivantamab + Chemo now @US_FDA approved in 2L mEGFR NSCLC after Osimertinib based off #MARIPOSA2: - mOS 17.7mos w/ Ami vs 15.3mos with chemo alone (HR 0.73), but ‘did NOT reach pre-specified significance’ - mPFS2 16mos vs 11.6mos (HR: 0.64) #ESMO24 #OncTwitter #lcsm
‼️ @FDAOncology approves amivantamab + chemo for EGFR+ mNSCLC after TKI progression per phase 3 MARIPOSA-2 study: ▫️ PFS: 6.3 v 4.2 mos (HR 0.48) ▫️ ORR: 53% v 29% ▫️ No OS difference at interim (HR 0.73) ▫️ AEs: rash, IRR, nail toxicity, stomatitis @OncoAlert #lcsm
Great point!! Agree. Not all mutations are the same. Data from #ASCO25 regarding #MARIPOSA2 suggests it is a strong option regardless of baseline osi resistance mechanism.
As combination strategies move to the frontline for our patients, how do we integrate the #MARIPOSA2 regimen in our practice? @BalazsHalmosMD @OncBrothers @jillfeldman4
Getting great questions from patients with EGFR+ lung cancer about the #MARIPOSA and #MARIPOSA2 studies after #ELCC25, and how they differ. What else should we add to this table to make it more helpful? @EGFRResisters @jillfeldman4
Updated @ASCO living guideline for Stage4 #NSCLC ŵ driver mutation Incorporates findings of #MARIPOSA and #MARIPOSA2: recommends consideration of Amivantamab in 1° and 2° #EGFR ex19 or L858R settings. Both studies improved PFS, OS immature ascopubs.org/doi/pdf/10.120…
Sequencing therapies for patients is so important! As of 9/2024–Amivantamab plus chemotherapy has FDA approval after progression on oral osimertinib per #MARIPOSA2.
The FDA approved #amivantamab with carboplatin & pemetrexed for adults with advanced #NSCLC with EGFR exon 19 deletions or exon 21 L858R mutations after prior EGFR TKI therapy. #MARIPOSA2 showed improved PFS vs. chemo alone (HR 0.48, P<0.0001). bit.ly/4evELjl
oncologynewscentral.com
FDA Approves Amivantamab (Rybrevant) Plus Chemo for EGFR-Mutated Advanced NSCLC
The FDA approved amivantamab with chemo in adults with certain EGFR-mutated advanced or metastatic NSCLC who received an EGFR TKI and had disease progression.
The FDA approved #amivantamab with carboplatin & pemetrexed for adults with advanced #NSCLC with EGFR exon 19 deletions or exon 21 L858R mutations after prior EGFR TKI therapy. #MARIPOSA2 showed improved PFS vs. chemo alone (HR 0.48, P<0.0001). bit.ly/4evELjl
oncologynewscentral.com
FDA Approves Amivantamab (Rybrevant) Plus Chemo for EGFR-Mutated Advanced NSCLC
The FDA approved amivantamab with chemo in adults with certain EGFR-mutated advanced or metastatic NSCLC who received an EGFR TKI and had disease progression.
#Amivantamab + Chemo now @US_FDA approved in 2L mEGFR NSCLC after Osimertinib based off #MARIPOSA2: - mOS 17.7mos w/ Ami vs 15.3mos with chemo alone (HR 0.73), but ‘did NOT reach pre-specified significance’ - mPFS2 16mos vs 11.6mos (HR: 0.64) #ESMO24 #OncTwitter #lcsm
‼️ @FDAOncology approves amivantamab + chemo for EGFR+ mNSCLC after TKI progression per phase 3 MARIPOSA-2 study: ▫️ PFS: 6.3 v 4.2 mos (HR 0.48) ▫️ ORR: 53% v 29% ▫️ No OS difference at interim (HR 0.73) ▫️ AEs: rash, IRR, nail toxicity, stomatitis @OncoAlert #lcsm
1. #MARIPOSA2: Update, Ph III, 2L in mEGFR after Osimertinib, Amivantamab + Chemo vs Chemo: - Recently approved in Europe - mOS 17.7mos w/ Ami vs 15.3mos with chemo alone (HR 0.73), but ‘did NOT reach pre-specified significance’ - mPFS2 16mos vs 11.6mos (HR: 0.64) 2/9
Excellent points about Mariposa2 trial . It is a good option but toxic and we need to be selective @5_utr @Alfdoc2 @Larvol @OncoAlert @DrJNaidoo @myESMO #ESMO24
And my favourite slide from #MARIPOSA2 study: huge heterogeneity of post-PD treatments in 3rd line. This underlines the vast heterogeneity of the disease and the need for options. #ESMO2024
@Rajatraj we have some data on that based off #MARIPOSA2 (Ami + Chemo or Ami + Laz + Chemo after upfront TKI). There is higher RR + PFS with Ami + Chemo +/- Laz vs Chemo. In most pts with progressive disease on Osi, I’ll likely add chemo and cont Osi or switch to Ami + Chemo.
L'amivantamab est disponible en accès précoce preAMM en deuxième ligne après échec d'un TKI et en association au carbo-pemetrexed, dans les mutations standards de l'EGFR. Une vraie avancée pour nos patients ! @HAS_sante @ansm @JanssenCilag #MARIPOSA2.
#ESMO23 💥 LAST Presidential3 @myESMO #MARIPOSA2 Amivantamab+Lazertinib+CT vs Amivantamab+CT vs CT #EGFRmut #NSCLC 📌 PFS 8.3 vs 6.3 vs 4.2m HR 0.48/0.44 📌 OS NS 📌 ORR 63 vs 64 vs 36% (OR 3.1) ☣️>G3 92% vs72% vs48% @ASCO @myESMO @_SEOM @OncoAlert @OncBrothers @weoncologists
Getting great questions from patients with EGFR+ lung cancer about the #MARIPOSA and #MARIPOSA2 studies after #ELCC25, and how they differ. What else should we add to this table to make it more helpful? @EGFRResisters @jillfeldman4
6. #MARIPOSA2: Amivantamab + Laz + Chemo Vs Chemo Vs Ami + Chemo in 2L activating EGFR mNSCLC after Osi. - Improved PFS with Ami combo: 8.3mos (Ami/Laz/Chemo), 6.3mos (Ami/Chemo), 4.2mos (HR: 0.44 and 0.42) - Improved CNS PFS - Significant AEs with combo @APassaroMD 7/7
🔥🚨@OncoAlert Hot off the press Just published @Annals_Oncology in conjunction with presentation @myESMO #ESMO23 Results of #MARIPOSA2 trial of #Amivantamab +chemo with & without #Lazertinib in #EGFR+ advanced #NSCLC post progression on #Osimertinib 👇🏼 annalsofoncology.org/article/S0923-…
#ESMO23 1> #lungcancer 1-15> (LBA15) Amivantamab Plus Chemotherapy (With or Without Lazertinib) vs Chemotherapy in EGFR-mutated Advanced NSCLC After Progression on Osimertinib: #MARIPOSA2, a Phase 3, Global, Randomized, Controlled Trial. #Osimertinib-resistant EGFR-mutant…
And my favourite slide from #MARIPOSA2 study: huge heterogeneity of post-PD treatments in 3rd line. This underlines the vast heterogeneity of the disease and the need for options. #ESMO2024
#Amivantamab + Chemo now @US_FDA approved in 2L mEGFR NSCLC after Osimertinib based off #MARIPOSA2: - mOS 17.7mos w/ Ami vs 15.3mos with chemo alone (HR 0.73), but ‘did NOT reach pre-specified significance’ - mPFS2 16mos vs 11.6mos (HR: 0.64) #ESMO24 #OncTwitter #lcsm
‼️ @FDAOncology approves amivantamab + chemo for EGFR+ mNSCLC after TKI progression per phase 3 MARIPOSA-2 study: ▫️ PFS: 6.3 v 4.2 mos (HR 0.48) ▫️ ORR: 53% v 29% ▫️ No OS difference at interim (HR 0.73) ▫️ AEs: rash, IRR, nail toxicity, stomatitis @OncoAlert #lcsm
@Rajatraj we have some data on that based off #MARIPOSA2 (Ami + Chemo or Ami + Laz + Chemo after upfront TKI). There is higher RR + PFS with Ami + Chemo +/- Laz vs Chemo. In most pts with progressive disease on Osi, I’ll likely add chemo and cont Osi or switch to Ami + Chemo.
🔥🚨@OncoAlert Hot off the press Just published @Annals_Oncology in conjunction with presentation @myESMO #ESMO23 Results of #MARIPOSA2 trial of #Amivantamab +chemo with & without #Lazertinib in #EGFR+ advanced #NSCLC post progression on #Osimertinib 👇🏼 annalsofoncology.org/article/S0923-…
Outstanding plenary presentation of the #MARIPOSA2 phase 3 trial by @APassaroMD, demonstrating the benefit of amivantamab/chemo (with or without lazertinib) over chemo in osi-refractory patients with EGFR-mutant NSCLC. #ESMO23
1. #MARIPOSA2: Update, Ph III, 2L in mEGFR after Osimertinib, Amivantamab + Chemo vs Chemo: - Recently approved in Europe - mOS 17.7mos w/ Ami vs 15.3mos with chemo alone (HR 0.73), but ‘did NOT reach pre-specified significance’ - mPFS2 16mos vs 11.6mos (HR: 0.64) 2/9
Excellent points about Mariposa2 trial . It is a good option but toxic and we need to be selective @5_utr @Alfdoc2 @Larvol @OncoAlert @DrJNaidoo @myESMO #ESMO24
UDAH BACA MARIPOSA 1 dari kak @lulukhf_stories ?? Kalo udah, Siap2 ikutan PO #Mariposa2 yaa.... Yang belum follow, follow dulu yak supaya ga ketinggalan info promo. Dan yang blm punya #Mariposa 1 bisa order di BukuWanita 😍😍 @coconutbooks_
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