#medchem search results
#research #medchem #influenza Design, synthesis, and activity evaluation of C-8 arylated luteolin derivatives as influenza endonuclease inhibitors (Tsalyy, Kráľ, Reiberger, Majer, @konvalinka_jan, Kožíšek, Machara) – @ACSPublications Bioorganic & Medicinal Chemistry Letters:
#research #drugdiscovery #medchem #chemistry The 2-aminopyrimidine ring as a new scaffold for potent MRP1 inhibitors (Čičak, Kozák, Hájek, Kraina, Kolman, Magdolenová, Viktorová, Mertlíková-Kaiserová, Janeba) – Eur. J. Med. Chem.: doi.org/10.1016/j.ejme… @IOCBPrague @VSCHT
A #postdocposition in the Drug Design and Medicinal Chemistry group @IOCBPrague headed by Radim Nencka is available for a highly motivated and creative scientist with expertise in organic & medicinal chemistry. Apply now. ⤵️ #orgchem #medchem #chemtwitter uochb.cz/en/open-positi…
#medchem #schistosoma #cathepsin Nature-Inspired Gallinamides Are Potent Antischistosomal Agents: Inhib. of the Cathepsin B1 Protease Target and Binding Mode Anal. (Mareš) - ACS Infect Dis: doi.org/10.1021/acsinf… @SpiwokovaPetra @IOCBPrague @VSCHT @UCSDPharmacy @CharlesUniPRG
#research #medchem #antifungals On-Resin Assembly of Macrocyclic Inhibitors of Cryptococcus neoformans May1: A Pathway to Potent Antifungal Agents (Kryštůfek, Verner, Šácha, Hadzima, Trajhan, Starková, Tloušťová, Dvořáková, Pecina, Brynda, Chalupský, Hájek, Boucher, Majer,
#research #medchem #virology Exploring advanced methodologies for NS5 methyltransferase targeted drug discovery (Otava, Drexler, Krafčíková, Chalupská, Chalupský, Veverka, Boura, Nencka) – Eur. J. Med. Chem.: doi.org/10.1016/j.ejme… @IOCBPrague @CzechAcademy @science_charles
#research #medchem #neurodegeneration Investigating NFE2L1 activators for targeted protein aggregate clearance: a follow-up study (Smahelova, Svobodova, Sedlacek, Adamek, Polidarova, Majer, Machara, Saskova) – RSC Med. Chem.: doi.org/10.1039/D5MD00… @IOCBPrague @CzechAcademy
Discovery of INCB126503, a selective FGFR2/3 inhibitor with gatekeeper mutant coverage and clean PK/safety, published in @ACSMedChemLett. #oncology #medchem #FGFR go.acs.org/cDK
📰 EFMC Literature Spotlight 📰 Novel Octahedral Nickel (II) Complex with Flexible Piperazinyl Moiety Exhibits Potent Cytotoxic Effect Along with Anti-Migratory and Anti-Metastatic Effect on Human Cancer Cells 🔗 More: buff.ly/3Tu4qRt #EFMCLiteratureSpotlight #MedChem
A most excellent molecule with which to conclude the week #SynChem #BB #MedChem #DrugDesign #DrugDiscovery #cheminformatics
Molecule of the week EN300-54771834 More details: bit.ly/4sRINcm Discover all the molecules of the week here: enamine.net/molecule-of-th… #Enamine #molecule #chemistry #science #drugdiscovery
Finally, my "firstborn" is out. The journey was already long and entropic enough so I just sent my gratitudes privately. All I know is that this is just the tip of the iceberg, and there is still so much more #medchem to learn and do. DOI: doi.org/10.1021/acsome… EPK~
1st disclosure of #HER2 exon20 insertion inhibitor BI 1810631 by Birgit Wilding @Boehringer at #EFMCASMC23. No #MedChem story without a “But” moment in lead optimization. In this case the need to overcome enzyme-mediated GSH addition - achieved by structure-activity assessment.
📣 Session 22 – The last speaker is Dr. Magnus PFAFFENBACH @biogen who will talk about “Discovery of BIO-8169, a Highly Potent, Selective, and Brain Penetrant IRAK4 Inhibitor for the Treatment of Neuroinflammation”. Keep following us! 🔬💡 #EFMCISMC24 #MedChem
We have a highly interesting job opening in our #MedChem department @merckgroup: Associated Director Medicinal Chemistry. We are looking for drug hunters with industry-experience & a passion for all types of small molecule drug modalities. linkedin.com/jobs/view/3902…
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📣 Session 23 – The last speaker is Dr Shabnam SHAABANI who will talk about “Automated and Miniaturized Chemistry”. Keep following us! 🔬💡 #EFMCISMC24 #MedChem
Ancora un'altra giornata di lavoro a #VialeLiegi il Presidente @GMFarinola e la Presidente della Divisione Chimica Farmaceutica @DCFSCI Maria Laura Bolognesi @mlbolognesi aprono il tavolo sull'industria farmaceutica per rafforzare i legami tra ricerca e mondo produttivo #medchem
Saluti dal Presidente della SCI @GMFarinola e della nostra Presidente @mlbolognesi all’apertura del Tavolo della Chimica Farmaceutica presso la sede @SocChimIta a Roma —> stay tuned #medchem #chemistry #chimica @SciGiovani
📣 Session 25 – The next speaker is Dr Nuria DIAZ who will talk about “Discovery of Muvalaplin: the First Oral Molecule Inhibitor of Lp(a) Formation in Clinical Trials”. Keep following us! 🔬💡 #EFMCISMC24 #MedChem
Excited to welcome Dr. James Crawford as a Plenary Speaker at MCCB2025 in Darwin, 13th–16th April 2025! 🌏🔬 Join us for cutting-edge science!🔗 bit.ly/3PNkUl6 #MCCB2025 #MedChem #ChemBio #DrugDiscovery #NT
Join keynote speakers Dr Amandeep Kaur, Prof. Tara Pukala & Prof. Sally-Ann Poulsen in Darwin (13-16 April) for insights into medicinal chemistry & chemical biology. 🔗 bit.ly/3PNkUl6 #MCCB2025 #MedChem #ChemBio #DrugDiscovery #NT
A most excellent molecule with which to conclude the week #SynChem #BB #MedChem #DrugDesign #DrugDiscovery #cheminformatics
Molecule of the week EN300-54771834 More details: bit.ly/4sRINcm Discover all the molecules of the week here: enamine.net/molecule-of-th… #Enamine #molecule #chemistry #science #drugdiscovery
📞Ring ring! Your hood is calling... it says it's time for new chemistry. Answer the call with cyclopentyl and cyclohexyl sulfonyl hydrazides. High purity, the lowest prices on the market, and same-day shipping to get your project moving. #KnightChem #MedChem
Landmark #publication was just pre-released on BioRx.com, highlighting the latest pharmacological data from the unique compounds we develop. Read the pre-print before the formal publication: biorxiv.org/content/10.648… #MedChem #Neuroplastogens #MindfulMedicine
Great MedChem by Design 2026 symposium last week #Boston 👏🥳 On behalf of the organizing committee, thanks to participants, and special thanks to guest speakers for sharing their expertise and insights! 👏🙏 Event agenda: bit.ly/3Pt81ji #DrugDiscovery #MedChem #CompChem
aacrjournals.org/cancerdiscover… Things I like about this: - Use of phenotypic screening - Upfront counterscreening for selectivity - Notable CAF-mediated MOA:⬆️ #ECM organization, collagen metabolism - Immediate translation into trials Also how long did this all take to do?... #medchem
A most excellent molecule with which to conclude the week #SynChem #BB #MedChem #DrugDesign #DrugDiscovery #cheminformatics
Molecule of the week EN300-53954444 More details: bit.ly/4dRiOhw Discover all the molecules of the week here: enamine.net/molecule-of-th… #Enamine #molecule #chemistry #science #drugdiscovery
"...simple, homogeneous “dump-and-stir” conditions." Discover the ease of sulfonyl hydrazide chemistry with bench-stable reagents, and simple work flows. #knightchem #medchem 🧠 Learn more at #knightschool 👉lnkd.in/g5gS3DdY
Want to start exploring sulfonyl hydrazides on smaller scale? Email us to place an order for < 1g of any product! #knightchem #medchem #hydrazide
Lots to be gleaned from this: pubs.acs.org/doi/10.1021/ac… But importantly appears that allostery in #kinases can be underestimated by cell-free kinase panels, especially for non-type I inhibitors #medchem
What a Bu-tiful hydrazide 🤩 Why settle for another phenyl ring when you can boost your Fsp3 with a cyclobutyl scaffold? No bottlenecks with same-day shipping & cost effective bulk pricing for screening. #knightchem #medchem
A most excellent molecule (and chemist) with which to conlude the week #SynChem #BB #MedChem #DrugDesign #DrugDiscovery #cheminformatics
Please welcome Yehor Torhashyn - the chemist behind the molecule of this week. Congratulations!👏 bit.ly/4c9q4Tn Discover all the molecules of the week here: enamine.net/molecule-of-th… #Enamine #molecule #chemistry #science #drugdiscovery
New video (4 min) on the recent @US_FDA approval of Lynavoy, a new treatment for cholestatic pruritus. Drug sponsor is @GSK. Video focuses on #medchem properties of the drug. #drugapproval youtu.be/YuBV8M5YW0E
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Inside Drug Discovery
A hydrazide a day keeps the doctor in play. Competitive chemistry, uncompromising quality, rapidly shipped to you. #knightchem #medchem
Skip the Mitsunobu, go straight to the hydrazide. Our growing collection of sulfonyl hydrazides are the cheapest on the market and get to your bench quickly with same-day shipping. #knightchem #medchem #sulfonylhydrazides
Behind every hydrazide there's a story, and that story is the Mitsunobu reaction.
A most excellent molecule with which to conclude the week #SynChem #BB #MedChem #DrugDesign #DrugDiscovery
Molecule of the week EN300-154279 More details: bit.ly/4drPvlA Discover all the molecules of the week here: enamine.net/molecule-of-th… #Enamine #molecule #chemistry #science #drugdiscovery
New video (5 min) on the recent @US_FDA approval of Foundayo, a new oral GLP1r ligand, for weight loss and weight maintenance. Drug sponsor is @EliLillyandCo. Video focuses on #medchem properties of the drug. #drugapproval youtu.be/oezfoLNus7I
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Inside Drug Discovery
New video (6 min) on the recent @US_FDA approval of Lifyorli for treatment of ovarian and related cancers with paclitaxel. Drug sponsor is @Corcept. Video focuses on #medchem properties of the drug. #drugapproval youtu.be/DFu0oQr4nCQ
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Inside Drug Discovery
Congratulations once again to all #ACSSpring2026 @AcsMedi CCG Excellence Award winners! 🏆🎉👏More info @ the ACS MEDI Division Awards webpage: bit.ly/47E23SZ #medchem #compchem #cadd
#PAINS and Prejudice #MedChem #cheminformatics fbdd-lit.blogspot.com/2026/04/pains-…
CALL FOR PAPERS The Journal of #DrugDiscovery and #Research (ISSN: 3107–720X) is inviting submissions for upcoming issues. globalmeetx.com/journals/jddr #MedChem #Pharmacology #PharmaceuticalSciences #Pharmacokinetics #DrugDevelopment #PharmaResearch #Biotech
#research #medchem #virology Exploring advanced methodologies for NS5 methyltransferase targeted drug discovery (Otava, Drexler, Krafčíková, Chalupská, Chalupský, Veverka, Boura, Nencka) – Eur. J. Med. Chem.: doi.org/10.1016/j.ejme… @IOCBPrague @CzechAcademy @science_charles
#research #drugdiscovery #medchem #chemistry The 2-aminopyrimidine ring as a new scaffold for potent MRP1 inhibitors (Čičak, Kozák, Hájek, Kraina, Kolman, Magdolenová, Viktorová, Mertlíková-Kaiserová, Janeba) – Eur. J. Med. Chem.: doi.org/10.1016/j.ejme… @IOCBPrague @VSCHT
#research #medchem #influenza Design, synthesis, and activity evaluation of C-8 arylated luteolin derivatives as influenza endonuclease inhibitors (Tsalyy, Kráľ, Reiberger, Majer, @konvalinka_jan, Kožíšek, Machara) – @ACSPublications Bioorganic & Medicinal Chemistry Letters:
#research #medchem #neurodegeneration Investigating NFE2L1 activators for targeted protein aggregate clearance: a follow-up study (Smahelova, Svobodova, Sedlacek, Adamek, Polidarova, Majer, Machara, Saskova) – RSC Med. Chem.: doi.org/10.1039/D5MD00… @IOCBPrague @CzechAcademy
1st disclosure of #HER2 exon20 insertion inhibitor BI 1810631 by Birgit Wilding @Boehringer at #EFMCASMC23. No #MedChem story without a “But” moment in lead optimization. In this case the need to overcome enzyme-mediated GSH addition - achieved by structure-activity assessment.
#research #medchem #antifungals On-Resin Assembly of Macrocyclic Inhibitors of Cryptococcus neoformans May1: A Pathway to Potent Antifungal Agents (Kryštůfek, Verner, Šácha, Hadzima, Trajhan, Starková, Tloušťová, Dvořáková, Pecina, Brynda, Chalupský, Hájek, Boucher, Majer,
Excited to welcome Dr. James Crawford as a Plenary Speaker at MCCB2025 in Darwin, 13th–16th April 2025! 🌏🔬 Join us for cutting-edge science!🔗 bit.ly/3PNkUl6 #MCCB2025 #MedChem #ChemBio #DrugDiscovery #NT
Join keynote speakers Dr Amandeep Kaur, Prof. Tara Pukala & Prof. Sally-Ann Poulsen in Darwin (13-16 April) for insights into medicinal chemistry & chemical biology. 🔗 bit.ly/3PNkUl6 #MCCB2025 #MedChem #ChemBio #DrugDiscovery #NT
ALERT- New blog & update! 🎉 Check out the refreshed Nanome documentation site with MARA & Nanome 2.0 info! Haven't tried MARA/2.0? Nothing beats trying it yourself; sign up for a demo today! #compchem #medchem #CADD #DrugDiscovery #drughunter #techbio nanome.ai/blog/major-upd…
Join keynote speakers Dr Pat Sharp, Dr Chiara Maniaci, Prof. Xin Zhang & Dr Madeline Kavanagh in Darwin (13-16 April) for insights into medicinal chemistry & chemical biology. 🔗 bit.ly/3FvPpKL #MCCB2025 #MedChem #ChemBio #DrugDiscovery #NT
Finally, my "firstborn" is out. The journey was already long and entropic enough so I just sent my gratitudes privately. All I know is that this is just the tip of the iceberg, and there is still so much more #medchem to learn and do. DOI: doi.org/10.1021/acsome… EPK~
📣 Session 22 – The last speaker is Dr. Magnus PFAFFENBACH @biogen who will talk about “Discovery of BIO-8169, a Highly Potent, Selective, and Brain Penetrant IRAK4 Inhibitor for the Treatment of Neuroinflammation”. Keep following us! 🔬💡 #EFMCISMC24 #MedChem
Join Dr Katherine Donovan, Prof. Paul Stupple & Dr Ludovica Monti in Darwin (13-16 April) for insights into medicinal chemistry & chemical biology. 🔗 bit.ly/3FvPpKL #MCCB2025 #MedChem #ChemBio #DrugDiscovery #NT
📰 EFMC Literature Spotlight 📰 Novel Octahedral Nickel (II) Complex with Flexible Piperazinyl Moiety Exhibits Potent Cytotoxic Effect Along with Anti-Migratory and Anti-Metastatic Effect on Human Cancer Cells 🔗 More: buff.ly/3Tu4qRt #EFMCLiteratureSpotlight #MedChem
If you're at #EFMCISMC24, visit us at EFMC Booth #59 to learn more about @ChemEurope! Get @Wiley_Chemistry book discounts, writing guides, special issues, cool pens & coasters! Meet our EiC! Then visit the @YoungSciNet Photo Booth for a souvenir. @EuroMedChem #medchem #chembio
Discovery of INCB126503, a selective FGFR2/3 inhibitor with gatekeeper mutant coverage and clean PK/safety, published in @ACSMedChemLett. #oncology #medchem #FGFR go.acs.org/cDK
🧬 EFMC Session at #ChemBioParis2025 "Genome Base Editing & Precision Chemistry for Therapy" Explore next-gen therapeutics with @HoebartnerLab & @BeiselLab 🎙 Organized by @EuroMedChem 📍 Paris | 🗓 Oct 6–9, 2025 🔗 chembioparis2025.com #ChemicalBiology #MedChem
One more paper is out today! New #diazoalkane to produce #medchem-relevant heterocycles in @ChemEurJ. Read more at doi.org/10.1002/chem.2… Dedicated to the people of Ukraine. #UkraineStands #terroruzziMustDie #HelpUkraine @EnamineLtd @KyivUniversity
🤩Absolutely thrilled to present our paper accepted for publication in @ACSBioMed on the discovery of unprecendented ssDAF-12 modulators to treat #strongyloidiasis. A long journey and a great collaborative effort with @CrucianiLab & Tes Pharma: pubs.acs.org/doi/full/10.10… #Medchem
Thrilled to announce Prof Greg Verdine as #RICT2024 inaugural speaker in Bordeaux, July 3-5, 2024! Don't miss his talk "Toward Universal Druggability" & many other presentations by renowned scientists.🔗rict2024.org Abstract submission by May 14! @SCT #MedChem #ChemBio
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