#reprochallenge 搜尋結果

#ClinicalEmbryology #ReproTwitter #ReproChallenge

Hello Williams, the whole thread from @fzambelli8 is compiled now. Read it here: threader.app/thread/1354821… #ReproChallenge

😍Today's #Reprochallenge is over, thanks 🙏a lot to all that participated, to the local crew @mina_popovic_ @fzambelli8 and @BuratiniJose and special thanks to @AidaPujolM. 😊 ⭐️To continue the repro fun, check out tomorrow the #ESHREjc on #fertilitypreservation @ESHRE 👋👋👋

Right, is comparing ETs from different patients all receiving split insemination by source of fertilization technique of the embryos. They are all first fresh ET. #ReproChallenge

Let's not forget, ICSI w/o male factor does not provide more reproductive success, not in LB, not in cumulative LB, and not even in terms of less FF. #ReproChallenge thelancet.com/journals/lance…

I don’t think so but when I talk to my colleagues gynaecologists, they are really afraid of having to tell a patient that there are no embryos #ReproChallenge

🟠In our survey, 35% respondents did split insemination, mostly to avoid FF. But, with reported rates in this paper and elsewhere, approx. 30 ICSI are needed to avoid 1 FF compared to IVF. 🤔Is this worth doing 29 useless ICSI to gain 1 less FF? #ReproChallenge

It would be interesting to know if there are differences in the frequency of split IVF/ICSI cases between countries. Do variations in reimbursement policies play a role? #ReproChallenge

Embryo grading is the main determinant for which embryo to transfer. They transfer the best regardless IVF or ICSI. Yet, IVF in most cases give nice embryos #ReproChallenge

Also, @OmarRawi89 , out of curiosity, if IVF embryos are of lower morphological score than ICSI ones, do you still transfer them first? #ReproChallenge

In this study they split with 10 CCOs, how many CCOs would you need to split? #ReproChallenge

This is very interesting! It seems that the main driver, in all papers (an our survey) is avoiding FF. But the FF avoided are few, and the ICSI very many... #ReproChallenge

Very interesting topic and paper. We follow this approach in many cycles. Clinicians and clinics are scared of no ET scenarios. This is a bit assuring to them. We always transfer the IVF embryos. I’m not saying this is absolutely justified cuz of the extra cost. #ReproChallenge

What do you think? Is it worth it? Does this look like a good approach? #ReproChallenge

🛑Limitations! ➡️Retrospective study ➡️Lots of DET and TET (!) hopefully at D2-3 ➡️No data on twins and singleton pregnancies ➡️SET could have skewed the results in favor of classical IVF? ➡️High number of oocytes (not for all) #ReproChallenge

🟥Rate of good-quality embryos was no different between embryos from conventional IVF (16.6%±23.2%) and from ICSI (16.6%±26.6%). 🟥ET done in 510 cycles, and no difference CP, abortion, ectopic pregnancy, and CBR were not different by source of embryo. #ReproChallenge

🟥FR per injected oocytes was higher (p<0.001) in the ICSI group (72.3%±24.3%) than after conventional IVF (59.2%± 25.9%) 🟥FR per retrieved oocytes was lower (p<0.001) in the ICSI group (52.1%±22.5%) than after conventional IVF (59.2%±25.9%). #ReproChallenge

➡️Embryos in ETs were: ✅166 from conventional IVF ✅66 from ICSI ✅278 from conventional IVF/ ICSI Clinical pregnancy ➡️ fetal heartbeat at week 7 #ReproChallenge

➡️Females aged 40 and older were excluded, and only cycles in which 10 or more oocytes were retrieved were analyzed in this study. ➡️Semen was always fresh. ➡️10.471 oocytes were retrieved: 4.915 were allocated to IVF and 5.556 to ICSI. #ReproChallenge

➡️555 couples underwent 571 IVF-ICSI split insemination. ➡️First cycle for 92% of them. ➡️Reason for treatment: mild mild asthenozoospermia (200 cycles), tubal factor infertility (112 cycles), or unexplained infertility (259 cycles). #ReproChallenge

Welcome to #ReproChallenge. Today’s paper covers very nice work from @KU_Leuven, where the group of @JorisVermeesch and the first author @ADestouni show that embryos with 1 or 0PN are not as bad as we thought.

In this specific cohort, which also needed PGT-M, 31% (13/42) of cycles reached ET or could repeat ET with an unaffected 0PN or 1PN embryo. The LBR per initiated cycle increased from 9.52 to 16.67%. #ReproChallenge

It was a very interesting discussion! Looking forward to the next one! 🤩🤩🤩 #ReproChallenge

Today’s paper asks the question: is bacterial vaginosis associated with a decreased probability of becoming pregnant? This is not ART, but natural conception in a cohort of women who are seeking a pregnancy. #ReproChallenge

6) Be kind, we are at #ReproChallenge to learn 7) There are no stupid questions, go ahead and ask!!

🔴In a few minutes we’ll start #ReproChallenge. Here are some simple housekeeping rules for this week: 1) Follow the #ReproChallenge and refresh often to see new comments and questions 2) This week the main thread will be hosted by @fzambelli8 so head over there 😊

The posteriorized embryo sac-like structures contained primordial germ cell-like cells, as well as cells that recapitulated the posterior primitive streak, resembling the onset of gastrulation. #ReproChallenge

Catching up on very interesting discussions after the class is over #ReproChallenge

Like in Waddington landscape of cell fate but the heterogeneities might be resulting in changes in the “paths” it would be up to each cell’s robustness to go down the path or be derailed #ReproChallenge

Join the discussion in today’s #ReproChallenge!

......at this point, some TE cells undergo mitosis ➡️the change in their shape (and increase in cortical tension beyond the threshold) ➡️breakage of the junctions ➡️ COLLAPSE! #ReproChallenge

⭐️Here is the paper, open access for all!😊 See you on #ReproChallenge Thursday 5.00-7.00 pm CET for the #tweetorial and live discussion!👋 ecerm.org/journal/view.p…

😍This IMPRESSIVE work helps us understand early embryonic growth, adding complexity to the model but also raising several interesting questions in ART. What do you think?? #ReproChallenge

Finally: ➡️blastocoel pressure influences the number of cells committing to different fates ➡️blastocysts with perturbed pressure showed an incorrect number (and localization) of TE and ICM #ReproChallenge

and then selects the proper embryos using AI !!! #ReproChallenge

🔴Results per ITT (after 351 patients included): b-HCG: 41.7% in D5 SET vs 33.5% in SET D3 Pregnancy W12: 33.1% in D5 SET vs. 21.6% in D3 SET Delivery: 32% D5 SET vs 21.6% in D3 SET All in all, 2 multiple births. #ReproChallenge

Not much is known about BV and natural fertility. This study by @Lokker and colleagues asks: what is the association between BV and fecundability (i.e. the per-menstrual cycle probability of pregnancy) in a cohort of Kenyan women trying to conceive? #ReproChallenge

The microfluidics device contained 3 parallel channels: a central channel for loading a gel matrix, a top channel for loading the stem cells, and a third channel containing flowing medium. #ReproChallenge

The anteriorized embryo sac-like structures contained epiblast-like cells at one pole and amniotic membrane-like cells at the other, resembling the human asymmetric embryonic sac prior to the onset of gastrulation. #ReproChallenge

🟥Total fertilization failure: 23 cycles of conventional IVF (4.0%) and in 8 cycles of ICSI (1.4%). Low fertilization: 65 cycles of conventional IVF (11.4%) and in 32 cycles of ICSI (17.0%). More details on FR by indication 👇 #ReproChallenge