#cisreg search results
While some of us were off at #Dros18 last week, @REDfly_database released its latest data update! Almost 900 records updated including many new CRMs as well as additional annotation for existing CRMs. Also 60 new demonstrated TF:TFBS interactions. #cisreg #Drosophila #enhancers
Comparative HiC shows evo of chromosome domain architecture: large-scale rearrangements mainly at TAD borders cell.com/article/S2211-… #cisreg
My review about enhancer mechanisms w/ @apombo1 now online ahead of print in bioessays dx.doi.org/10.1002/bies.2… #cisreg
The final program for the RegSys COSI Track Presentations at #ISMBECCB2019 is now available iscb.org/cms_addon/conf… speakers include @Eileen_Furlong and @steinaerts and registration is still open so come and join us in Basel July 21-25! #cisreg #compbiol #Bioinformatics
Really interesting data by W.Bickmore on novel mechanism of Shh activation by brain enhancer: not looping, but chromatin decompaction (+'facilitated tracking'), mediated by PARP. biorxiv.org/content/biorxi… #ECD17 #cisreg
A 50-year riddle abt genetic cause of the mouse Hammertoe mutant is solved! Caused by insertion of chr14 sequence w #enhancer activity in Sonic hedgehog regulatory region, which results in ectopic+extended expression of gene during limb dev pnas.org/cgi/content/lo… #cisreg
of boundary #CTCF,b surprised by large effect.Unexpected(pour moi),bc evo turnover.Wld b gr8 2 c cntrl: del of non-boundary CTCF.#cisreg 3/3
Giorgetti lab: Structural Fluctuations of the Chromatin Fiber within Topologically Associating Domains dx.doi.org/10.1016/j.bpj.… #cisreg
Major new update! Not only did we add ~50 new reporter constructs and update info on over 800 more, we introduced the beta version of our new Search and Download interface with vastly expanded and improved functionality. Try it out! #cisreg #enhancers #drosophila
Our new paper is out for the @NAR_open 2019 Database Issue! Get an early view of some upcoming improvements. academic.oup.com/nar/advance-ar… #cisreg #generegulation #enhancers #TFBS #biocuration #Drosophila
PhD position on mammalian genomics and genome architecture (experimental+computational work) with an awesome young PI in Berlin! #cisreg
Open PhD positions to join our lab. Don't miss the opportunity!! :-D mdc-berlin.de/jobs/808418/10…
Just in time for holidays: role of Nipbl(#cohesin)in genome org+2 independent mechs for folding chromosomes biorxiv.org/content/early/… #cisreg
Not keen on the word loopome but enjoyed this more than I was expecting youtube.com/embed/dES-ozV6… "hi-c now with 10000% more contacts" #cisreg
For those at #BSDBGenSoc2024 don't miss @joadelas poster P38 today at 12:00-14:00 Unpublished work on how spatial and temporal patterning cues are integrated to coordinate patterning in the vertebrate neural tube #cisreg #GRN
Loci that co-occur more frequently within slices are closer within 3D nuclear space (method developed by @RobBeagrie ) #emboomics #cisreg
Young+Ibn-Salem papers sggst enhancers intrinsicly promiscuous(no promotr spec),bc enhancr adoption readily occurs upon boundary del #cisreg
Our latest update is out! We updated almost 400 records with developmental staging data and additional expression data. 29 new papers added, 10 all-new sequences, 31 new TFBS. #cisreg #enhancers #drosophila Don't forget to visit our poster 778A at #TAGC20!
Hi-C domains can define regulatory modules in-vivo blog.rob.beagrie.com/2014/05/07/enh… my thoughts on a recent @genomeresearch paper #cisreg
Major new update! Not only did we add ~50 new reporter constructs and update info on over 800 more, we introduced the beta version of our new Search and Download interface with vastly expanded and improved functionality. Try it out! #cisreg #enhancers #drosophila
For those at #BSDBGenSoc2024 don't miss @joadelas poster P38 today at 12:00-14:00 Unpublished work on how spatial and temporal patterning cues are integrated to coordinate patterning in the vertebrate neural tube #cisreg #GRN
Omg, I had read: “enhancer cancer protection”....I thought you were either kidnapped or saw the light. #cisreg
Our latest update is out! We updated almost 400 records with developmental staging data and additional expression data. 29 new papers added, 10 all-new sequences, 31 new TFBS. #cisreg #enhancers #drosophila Don't forget to visit our poster 778A at #TAGC20!
The final program for the RegSys COSI Track Presentations at #ISMBECCB2019 is now available iscb.org/cms_addon/conf… speakers include @Eileen_Furlong and @steinaerts and registration is still open so come and join us in Basel July 21-25! #cisreg #compbiol #Bioinformatics
Our new paper is out for the @NAR_open 2019 Database Issue! Get an early view of some upcoming improvements. academic.oup.com/nar/advance-ar… #cisreg #generegulation #enhancers #TFBS #biocuration #Drosophila
While some of us were off at #Dros18 last week, @REDfly_database released its latest data update! Almost 900 records updated including many new CRMs as well as additional annotation for existing CRMs. Also 60 new demonstrated TF:TFBS interactions. #cisreg #Drosophila #enhancers
A 50-year riddle abt genetic cause of the mouse Hammertoe mutant is solved! Caused by insertion of chr14 sequence w #enhancer activity in Sonic hedgehog regulatory region, which results in ectopic+extended expression of gene during limb dev pnas.org/cgi/content/lo… #cisreg
Not visible in our @REDfly_database v5.4 release are many behind-the-scenes improvement to our curation workflow. What does this mean? Many many new CRMs and TFBSs coming your way in early 2018! #drosophila #cisreg #enhancers #TFBS
REDfly v5.4 released-check out our updated look and feel! (Safari users might need to refresh the cache). New records, improved searchability, better 'contact us' page. #drosophila #cisreg #enhancers
Really interesting data by W.Bickmore on novel mechanism of Shh activation by brain enhancer: not looping, but chromatin decompaction (+'facilitated tracking'), mediated by PARP. biorxiv.org/content/biorxi… #ECD17 #cisreg
D.Higgs talks abt recent work on alpha-globin locus: deletion of CTCF sites flanking the reg region leads to shift of interactions+upreg of more distal genes #ECD17 #cisreg Paper: ncbi.nlm.nih.gov/pubmed/28737770
PhD position on mammalian genomics and genome architecture (experimental+computational work) with an awesome young PI in Berlin! #cisreg
Open PhD positions to join our lab. Don't miss the opportunity!! :-D mdc-berlin.de/jobs/808418/10…
Just finished reading cool paper on Indian hedgehog (Ihh) #enhancer landscape by @MundlosLab @Dariloops nature.com/ng/journal/vao… #cisreg 1/3
Just in time for holidays: role of Nipbl(#cohesin)in genome org+2 independent mechs for folding chromosomes biorxiv.org/content/early/… #cisreg
Morning task: grab cup of tea and read about cool new 3C-based method from Tanay lab @WeizmannScience dx.doi.org/10.1038/nature… #cisreg
Similar finding re: hierarchy within #enhancers found last year in STAT5-driven Wap superenhancer nature.com/ng/journal/v48… #cisreg #EMBOomics
Loci that co-occur more frequently within slices are closer within 3D nuclear space (method developed by @RobBeagrie ) #emboomics #cisreg
And another article about #evolution of limb #enhancers (incl Shh) this week. Great minds think alike? ;) cell.com/current-biolog… #cisreg
. @der_bri @mamartl @MundlosLab Awesome work! Congrats! One more piece to understand #cisreg and #3Dorganisation of the genome...
Formation of new chromatin domains determines pathogenicity of genomic duplications nature.com/nature/journal… Very interesting. Via @kcakdemir
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