#mendelianrandomization search results
Blood pressure, plasma proteins, and cardiovascular diseases: a network Mendelian randomization and observational study . Read more in the @EHJ at doi.org/10.1093/eurhea… #CardiovascularHealth #BloodPressure #MendelianRandomization #PlasmaProteins @ESCardio @ESC_Journals
Multi-omics #MendelianRandomization and Single-Cell Analysis Identify Novel Therapeutic Targets for #Osteosarcopenia: academic.oup.com/biomedgerontol… @geronsociety
academic.oup.com
Multi-omics Mendelian Randomization and Single-Cell Analysis Identify Novel Therapeutic Targets for...
AbstractBackground. Osteosarcopenia, defined by the coexistence of osteoporosis and sarcopenia, presents a significant health challenge for aging populatio
Happy to see this project led by @ElePorcu and @zkutalik out in @eLife! We developed a #MendelianRandomization framework that taps into #metabolomics data to identify new causal relationships between changes in 🧬 expression and complex traits. Article: elifesciences.org/articles/81097
Beautiful study by @RobGersztenMD @pnatarajanmd connecting the proteome and metabolome with #MendelianRandomization. Or how MR has evolved from answering risk factor-disease questions to the leading method for drawing causal arrows between omics layers authors.elsevier.com/c/1hat35WXUlSw…
Final touches on my introduction to #mendelianrandomization workshop as part of the #AusUKB2024 instruction day at @IMBatUQ next week. Can’t wait for what looks like three interesting days!
Understanding the control of body weight through #Genetics #Mendelianrandomization #GWAS and characterization of the brain proteome @iScience_CP @ArsenaultBenoit cell.com/iscience/fullt…
In the next #ESHG2023 poster session come and speak to Francesco about his work showing a causal link between serum iron and non-Alzheimer's #dementia (but not AD) using #MendelianRandomization P20.010.B Funded by @NIHAging with @Ferruccilu @ExeterMed @eshgsociety #Genetics
👉New research by Yupeng Han, et al. "Analysis of the correlation between #ImmuneCellCharacteristics and #insomnia: a #MendelianRandomization study" 🖱ow.ly/5BMH50QLbQr #correlation #Neurophysiology
🔬New Editorial: Attention to the misuse of Mendelian randomisation in medical research. 🔍Unpacking MR's role in causal inference: Why tool variable selection, sensitivity analyses, and interdisciplinary collaboration are critical. 📈👇#MendelianRandomization #MedicalResearch 📖…
💡Explore the new editorial in eGastroenterology! 🔍Attention to the misuse of Mendelian randomisation in medical research 🚨Explore critical insights into MR misuse trends and implications, paired with data on publications/citations (2015–2024). 📊👇#MendelianRandomization…
In #MendelianRandomization we normally assume genetic variants for an exposure have consistent causal effects @xiaoran_liangxl has a poster today #ESHG2023 on her work clustering variants by their causal effect to better understand mechanisms @GEMINIcollab @eshgsociety
(1/4) 2 decades ago @mendel_random described strengths & weaknesses of #MendelianRandomization(MR) in studying #environmental determinants of diseases (academic.oup.com/ije/article/32…). 20 yrs later same authors comment on misusing MR (thelancet.com/journals/landi…) Take home 👇 #Epitwitter
Can #genetics and drug target #Mendelianrandomization foreshadow outcomes and contributing mechanisms linking GLP-1 receptor signalling to reduction of #MASH @Gut_BMJ gut.bmj.com/content/early/…
Excited to hear George Davey Smith @mendel_random talk about "Noodles, No Nulls and Numb Skulls: Threats to the future of Mendelian Randomization" at our department seminar series @exeter_med @uniofexeHLS #epidemiology #Genetics #MendelianRandomization
Co-localisation and cis-#MendelianRandomization provide genetic evidence for targeting IL-2, IL-6 and TYK2 signalling in prevention of type 1 #diabetes @karhunen_v @dpsg108 #T1D #DiabetesResearch tinyurl.com/44kwru35 🔓
Delighted to host super @LouiseVwain at #Hcor research institute scientific meeting TODAY She will speak about #mendelianrandomization 🤩 A super cool topic! A partnership between Hcor and @fsp_usp
#MendelianRandomization analyses identify #causal associations of human #gut #microbiome composition on #intelligence medrxiv.org/content/10.110… #Cognition #brainvolume #gutbrainaxis #GWAS risk effect- #Oxalobacter protective- #Fusicatenibacter
Using #Mendelianrandomization nd #residualmethod to explre assciation betwn genetically predcted highr #25OHvitD nd #mortality in #UKBiobank , our study show a linear assction fr #respiratorydisease morty nd fr #cardiovasculardisease nd #cancermortality acpjournals.org/doi/abs/10.732…
A practical guide for nephrologist peer reviewers: understanding and appraising Mendelian randomization studies #Nephrology #MedEd #MendelianRandomization @wisit661 @MayoClinicNeph tandfonline.com/doi/full/10.10…
Mendelian randomization was undertaken to explore the relationship between VEGF and ischemic stroke, suggesting that high VEGF levels may not predict the risk of stroke under clinical circumstances. link.springer.com/article/10.100… #NeurologyAndTherapy #MendelianRandomization #Stroke
This research letter integrates #MultiOmics and #MendelianRandomization analyses to identify #PANoptosis genes #BCL2L1 and UBC as key regulators of #MyocardialInfarction (MI) via #DNAMethylation, revealing BCL2L1 as a promising therapeutic target for MI intervention.…
A #MendelianRandomization Study showed negative correlation between #olive intake and the incidence of CHD and cardiovascular outcomes, suggesting increasing olive intake may hold great value in preventing the onset and progression of CHD. #HF #MI #Stroke journals.lww.com/cd/fulltext/20…
Blood pressure, plasma proteins, and cardiovascular diseases: a network Mendelian randomization and observational study . Read more in the @EHJ at doi.org/10.1093/eurhea… #CardiovascularHealth #BloodPressure #MendelianRandomization #PlasmaProteins @ESCardio @ESC_Journals
Multi-omics #MendelianRandomization and Single-Cell Analysis Identify Novel Therapeutic Targets for #Osteosarcopenia: academic.oup.com/biomedgerontol… @geronsociety
academic.oup.com
Multi-omics Mendelian Randomization and Single-Cell Analysis Identify Novel Therapeutic Targets for...
AbstractBackground. Osteosarcopenia, defined by the coexistence of osteoporosis and sarcopenia, presents a significant health challenge for aging populatio
🧬 New study uses bidirectional Mendelian randomization to reveal causal links between obesity, type 2 diabetes, hypertension, and gout. 🔗 Read Open Access: oaepublish.com/articles/mtod.… #CardiometabolicResearch #Genetics #MendelianRandomization #MedicalResearch
#MendelianRandomization study reveals a causal link between gut microbiota and sarcopenia-related traits like hand-grip strength and lean mass! This is a major step in understanding the #GutMuscleAxis. bit.ly/47zVzFr
#Smoking may raise viral #hepatitis risk up to 5.3x, new study finds via #MendelianRandomization. Reinforces the urgent need for #SmokingCessation to prevent liver disease. Read: tobaccoinduceddiseases.org/Ascertaining-t… By Birong Lin et al. | @EurPublishing
#MendelianRandomization and mediation analysis reveals a complex yet strong relationship between #ImmuneCells and blood metabolites in promoting and preventing #Urolithiasis. #KidneyStones #OpenAccess: sciencedirect.com/science/articl…
Our latest research reveals a surprising protective effect of #hypothyroidism against #EndometrialCancer (EC) risk. This challenges previous observational studies and highlights the power of #MendelianRandomization in uncovering causal relationships. 🔗 mdpi.com/2227-9059/13/7…
Using #MendelianRandomization analysis, researchers at @2024HUST demonstrate a bidirectional causal relationship between the #GutMicrobiota and #Infertility, and identify different genera associated with male/female #Infertility. #MostDownloaded: link.springer.com/article/10.100…
🧪 New study reveals a causal link between #NephroticSyndrome and #AtopicDiseases using bidirectional #MendelianRandomization. Findings suggest a two-way relationship, highlighting shared #genetic and #immune pathways. Here 🔗 doi.org/10.1111/pai.70… . #PAI_journal
Altered metabolism of #acylcarnitines – transporting fatty acids to mitochondria – may play a causal role in #depression. Pre-print from @Ygoes2B_more and team using genetic correlations & #Mendelianrandomization with @PGCgenetics sumstats: medrxiv.org/content/10.110…
Amazing intro on Mendelian Randomization methods at @capice_project 5th workshop at University of Bristol. #CAPICEBristol @ammegandchips @MarcusMunafo @DeborahLawlor2 @MCarol_Borges #causalinference #MendelianRandomization @BristolTARG
👉New research by Yupeng Han, et al. "Analysis of the correlation between #ImmuneCellCharacteristics and #insomnia: a #MendelianRandomization study" 🖱ow.ly/5BMH50QLbQr #correlation #Neurophysiology
Low plasma #adiponectin is associated with an increased risk of #type2diabetes observationally. Genetically, a causal association between plasma adiponectin and risk of type 2 diabetes cannot be excluded using #Mendelianrandomization. #diabetes #mendelianrandomisation
Understanding the control of body weight through #Genetics #Mendelianrandomization #GWAS and characterization of the brain proteome @iScience_CP @ArsenaultBenoit cell.com/iscience/fullt…
Happy to be in Bristol for a crash course in #MendelianRandomization. Been waiting for this!! @Luisa_Zu @BristolTARG @capice_project #CAPICEBristol
Blood pressure, plasma proteins, and cardiovascular diseases: a network Mendelian randomization and observational study . Read more in the @EHJ at doi.org/10.1093/eurhea… #CardiovascularHealth #BloodPressure #MendelianRandomization #PlasmaProteins @ESCardio @ESC_Journals
BioDecoded Daily Digest | May 27 2020 biodecoded.com/2020/05/27/dai… #COVID19 #MendelianRandomization #ComplexNetwork #DeepLearning
Congratulations to @minouye271 and colleagues for their new #metabolomics #GWAS with #MendelianRandomization on @medrxivpreprint, using a non-targeted LC-MS/MS platform with 11,000 features in almost 9,300 individuals medrxiv.org/content/10.110…
Q: Does #MendelianRandomization give results comparable to RCTs? Answer: Pretty close 25k participant vitamin D trial shows no effect on cardiovascular outcomes. (HR = 0.96; 0.88-1.06) in @NEJM. Our #MendelianRandomization study in 2016 showed an OR of 0.99 (0.84-1.17).
How does GERD increase the risk of heavy menstrual bleeding? news-medical.net/news/20230827/… #GERD #HMB #MendelianRandomization #CausalLink #WomenHealth #MenstrualCycles #Genomics #ResearchSquare #BMI #Estrogen @ResearchSquare
BioDecoded Daily Digest | September 15 2020 biodecoded.com/2020/09/15/dai… #MachineLearning #bioinformatics #MendelianRandomization
Paper in press: "Lipid and Metabolic Syndrome Traits in Coronary Artery Disease: A Mendelian Randomization Study" – #CoronaryArteryDisease #MendelianRandomization #HDL #LDL jlr.org/content/early/… @WeillCornell @Columbia
Beautiful study by @RobGersztenMD @pnatarajanmd connecting the proteome and metabolome with #MendelianRandomization. Or how MR has evolved from answering risk factor-disease questions to the leading method for drawing causal arrows between omics layers authors.elsevier.com/c/1hat35WXUlSw…
Genetic twist in gallstone disease may shield against heart attacks 💡🔬❤️ news-medical.net/news/20231105/… Gallstones #HeartHealth #MendelianRandomization #AcuteMyocardialInfarction #CoronaryHeartDisease #Genetics #Cholesterol #Epidemiology #Biobanks #Cardiology @SciReports
Can #genetics and drug target #Mendelianrandomization foreshadow outcomes and contributing mechanisms linking GLP-1 receptor signalling to reduction of #MASH @Gut_BMJ gut.bmj.com/content/early/…
A practical guide for nephrologist peer reviewers: understanding and appraising Mendelian randomization studies #Nephrology #MedEd #MendelianRandomization @wisit661 @MayoClinicNeph tandfonline.com/doi/full/10.10…
Identifying molecular mediators of the relationship between body mass index and #endometrial cancer risk: a #Mendelianrandomization analysis. Read it here: bmcmedicine.biomedcentral.com/articles/10.11…
Lipid and metabolic syndrome traits in coronary artery disease: a #Mendelianrandomization study — @WeillCornell @Columbia #lipoprotein #CoronaryArteryDisease jlr.org/article/S0022-…
Using #MendelianRandomization, new study finds higher iron status is associated with an increased risk of cardioembolic stroke, independent of other CV risk factors. #AHAJournals @AlexaBarad @theobrienlab @CornellNutri ahajrnls.org/4cktPo8
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