#smoothmusclecell search results

The quantitative analysis of Re-orientation of #SmoothMuscleCell #CollagenFiber in🐭#Atherosclerosis #Calcification Annexin A2/5/6 (#MatrixVesicle markers)⬆️ only seen in zones of SMC/Collagen disorganization Xufeng Niu & Yubo Fan labs Research 2025 spj.science.org/doi/10.34133/r…

Gelsolin as a selective #Pericyte marker vs #SmoothMuscleCell Fibroblast in mouse #SkeletalMuscle Antibody R&D MAB8170 Cryosection BulkRNAseq (SkM PDGFRβ+SMA− pericyte vs PDGFRβ+SMA+ SMC) vs (Brain pericyte vs SMC) #SciRep 2025 nature.com/articles/s4159…

PRMT5 di-methylates H3R8 & H4R3▶️ ⏬Myocardin-dependent #SmoothMuscleCell contractile gene transcription ⏫SMC proliferation/migration & intimal hyperplasia in injured🐭carotid artery PRMT5 (& PRMT4) ⬆️in PDGF-BB-treated SMC & 👤coronary #Atherosclerosis Evidence from SMC PRMT5…

PRMT5 methylates & stabilizes KLF4 protein▶️ ⏫#SmoothMuscleCell proliferation/migration & intimal hyperplasia in injured🐭carotid artery Evidence from #SmoothMuscleCell PRMT5 KO🐭 & Lentiviral PRMT5 PRMT5⬆️ in👤carotid stenosis & PDGF-BB-treated SMC #CardioVascRes 2023…

PRMT5 methylates NF-κB p65 to enhance trimethylamine N-oxide-NOX4-induced #SmoothMuscleCell inflammation SM22α+ SMC PRMT5 KO🐭 + carotid wire injury + TMAO i.p.▶️ ⏬p65 methylation ⏬Vascular cell VCAM1 ⏬CD68 recruitment #CellDeathDis 2022 @cddpress nature.com/articles/s4141…

#SmoothMuscleCell m6A Epitranscriptomics METTL14 ⬆️in 🐭#ThoracicAorticAneurysm (AngII + HFD) or erastin-treated SMC Liproxstatin-1 or AAV-shMettl14 rescues 🐭TAA METTL14-IGF2BP2 stabilizes ACSL4 mRNA➡️ SMC #Ferroptosis SRAMP/deepSRAMP: m6A site prediction @AJPCellPhys 2025…

#SmoothMuscleCell Mettl14, ⬆️in injured artery, aggravates #IntimalHyperplasia via ⏫nascent KLF4 & SERPINE1 mRNA synthesis (Not impacting mRNA stability) Likely Mettl3, but not other m6A readers/writers/erasers, plays a minor role @JCI_insight 2025 insight.jci.org/articles/view/…

#SmoothMuscleCell m6A Epitranscriptomics METTL3 & WTAP (m6A writer) ⬆️in👤carotid arterial intima METTL3-YTHDC1 (m6A reader) ⏫SGK1 mRNA synthesis (but not stability) 135 candidate METTL3 target genes by RNAseq + MeRIPseq in rat SMC SMC Mettl3 KO🐭➡️ ⏬injured carotid…

NRIP2+ #SmoothMuscleCell (likely mediating metabolic resilience by antagonizing Leptin signaling) #AorticDissection Leptin antagonist (R128Q) or AAV9-SM22a-NRIP2 ⏬🐭AD #AorticRupture (BAPN) ⏫SMC contractile phenotype in vivo ⏫SMC mitochondrial ultrastructure & OXPHOS in vitro…

#VascularCalcification #SmoothMuscleCell m6A Epitranscriptomics High Pi ⏬METTL3 in SMCs METTL3-YTHDF2 destabilizes RUNX2 mRNA & ⏬ SMC Osteogenesis S-Adenosylhomocysteine as METTL3/14i aggravates aortic calcification in CKD 🐭 (adenine + hi Pi diet) @CommsBio 2025…

#Atherosclerosis #SmoothMuscleCell m6A Epitranscriptomics Mettl3-YTHDF3⏫m6A-modified MTRFA mRNA (⬆️translation, not stability) in SMCs➡️ ⏫cholesterol-induced gain of macrophage-like phenotype ⬆️Lipid loading VCAM1 IL6 ⬇️Contractile markers SMC Mettl3 KO🐭 +HFD AAV-PCSK9➡️…

GPR153-cAMP/CREB-#YAP/TAZ or -NFκB cascades in #EndothelialCell #SmoothMuscleCell Orphan GPCR profiling in SMC GPR153 ⏫in SMC in intima, atheroma, MI ischemic zone ⏫in EC in inflamed SkM, Brain siGPR153➡️ ⏬SMC proliferation -/+contractile phenotype (highly…

#SmoothMuscleCell Contractility regulated by m6A Epitranscriptomics METTL3 as a direct target gene of YY1 (+SET1A/WDR82) METTL3-IGF2BP1 stabilizes mRNAs of MYH11, MYLK2, TGFβ2 SMC Yy1 or Mettl3 KO🐭 ⏬vasoconstriction ↔️vasorelaxation AAV-SM22-METTL2 i.v. ⏫arterial…

#SmoothMuscleCell m6A Epitranscriptomics METTL3-YTHDF3 enhances Profilin-1 mRNA translation➡️ ⏫SMC proliferation migration ⏬SMC contractile phenotype METTL3 YTHDF3 PFN1 ⬆️in PDGF-BB-treated SMC & injured carotid artery SMC Mettl3 or Pfn1 KO🐭➡️ ⏬wire-injured carotid…

BRD4 stabilizes the chromatin occupancy of NIPBL/delangin, a cohesion loading factor, & maintains chromatin loops & genome folding Wnt1+ Neural Crest Brd4 KO🐭 👉⏬#SmoothMuscleCell invested on aortic arch e11.5 👉⏬SMC on aorta & pulmonary artery e14.5 👉Severe craniofacial…

#SmoothMuscleCell DOT1L, H3K79 methyltransferase, KO🐭➡️ ⏬lesion burden ⏬lesional leukocyte/Mφ ⏫plaque stability DOT1L ⬆️in PDGF-BB-treated SMC, 👤carotid #Atherosclerosis, 👤popliteal arterial aneursym shDOT1L in SMC➡️ ⏬proliferation ⏫contractile phenotype 75% 1-h…

Histone Variants underlie #SmoothMuscleCell phenotypic plasticity 1⃣H2A.Z (⬇️in #Atherosclerosis, enriches at nucleosome associated with accessible chromatin regions downstream of TSS) ⏫SMC contractile gene via recruiting SMAD3 & MED1 @CircAHA 2018 ahajournals.org/doi/10.1161/CI……

#Atherosclerosis Epitranscriptomics Cell type-specific dysregulation of m6A machinery in pro-atherogenic phenotypes of #EndothelialCell (ALKBH5) #SmoothMuscleCell (WTAP) Mφ (METTL3 YTHDF2) Re-analysis of scRNAseq Wirka's Nat Med 2019 pmc.ncbi.nlm.nih.gov/articles/PMC72… @THNOdotORG 2025…

#SmoothMuscleCell m6A Epitranscriptomics METTL3 ⏫in human #ArterioVenousFistula stenosis SMC Mettl3 KO🐭 ⏬#IntimalHyperplasia at AVF Mettl3-YTHDF1 stabilizes SLC7A11 mRNA➡️ ⏬SMC contractile phenotype ⏫SMC proliferation/migration ⏬Lipid peroxidation Ferroptotic death?🧐…

#VascularCalcification DNA N6-methyladenine/6mA (NOT m6A) of BMP2 gene ⏬OCT4-dependent transcription & #SmoothMuscleCell Calcification ALKBH1, an eraser of 6mA ⬇️in calcified radial artery of👤CKD ⏫aortic calcification in 🐭+Adenine diet @jclinicalinvest 2021…

The quantitative analysis of Re-orientation of #SmoothMuscleCell #CollagenFiber in🐭#Atherosclerosis #Calcification Annexin A2/5/6 (#MatrixVesicle markers)⬆️ only seen in zones of SMC/Collagen disorganization Xufeng Niu & Yubo Fan labs Research 2025 spj.science.org/doi/10.34133/r…

Gelsolin as a selective #Pericyte marker vs #SmoothMuscleCell Fibroblast in mouse #SkeletalMuscle Antibody R&D MAB8170 Cryosection BulkRNAseq (SkM PDGFRβ+SMA− pericyte vs PDGFRβ+SMA+ SMC) vs (Brain pericyte vs SMC) #SciRep 2025 nature.com/articles/s4159…

PRMT5 di-methylates H3R8 & H4R3▶️ ⏬Myocardin-dependent #SmoothMuscleCell contractile gene transcription ⏫SMC proliferation/migration & intimal hyperplasia in injured🐭carotid artery PRMT5 (& PRMT4) ⬆️in PDGF-BB-treated SMC & 👤coronary #Atherosclerosis Evidence from SMC PRMT5…