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Which Genes are Most Commonly Mutated in Cancer? Salk Scientists Find Out When @salkinstitute scientists revealed the most commonly mutated genes in all cancers, they found that some mutations are not as common as previously thought. Learn more: ow.ly/oLQx50Grpuu
The leap forward in protein structure prediction by @DeepMind's AlphaFold2 in #CASP14 highlights a potential to revolutionise structure determination. The open availability of 170,000+ structures in the PDB has been harnessed to solve a problem that stretches back decades
I hope this is a provocative text to trigger new experiments to connect #chromatin, #DNAreplication & #transcription and explain the transcriptional phenotype of #Arabidopsis mutants of various DNA polymerases #histone #epigenetics authors.elsevier.com/a/1c4EP4rGdjMH… @TrendsPlantSci
Our paper entitled "The Biology of Cell-free DNA Fragmentation and the Roles of DNASE1, DNASE1L3, and DFFB" was chosen as an annual Best of AJHG 2019-2020
#ASHG20 Celebrate the groundbreaking research published in @AJHGNews with this collection! Download the Best of AJHG 2019 and 2020. hubs.ly/H0yGD-P0
finally online～ Plasma DNA Profile Associated with DNASE1L3 Gene Mutations: Clinical Observations, Relationships to Nuclease Substrate Preference, and In Vivo Correction cell.com/ajhg/fulltext/…
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The EMBO workshop "Chromatin dynamics and nuclear organisation in genome maintenance" will take place online from December 7-10, 2020. Check out our fantastic list of speakers and register before November 30, 2020 at meetings.embo.org/event/20-chrom…. Please RT
Very happy and proud to present: The GTEx papers. This set of 15 papers published today describes the final phase of this 10-year effort, providing the genomics community an atlas of genetic regulatory variants and a deep dive into the biology behind it. sciencemag.org/collections/ge…
Happy to share you our freshly published work on @NatMachIntell. We proposed GEEK, a flexible, network-embedding-based framework integrating heterogeneous biological knowledge to study their joint effects on gene expression. Read full text: rdcu.be/b5R48
I have an cfDNA joke, please don't digest me!
A lot of nuggets to sift through in the latest from @DahletThomas and Michael Weber, including the most convincing in vivo data I've seen that DNA methylation plays a role in restricting cryptic promoters in gene bodies in mammals. nature.com/articles/s4146…
Yun, Park, Park and co look at gene fusions in 268 tumors. Some fusions do not produce chimeric mRNAs but cause upregulation of driver genes by modifying regulatory regions. Gene-intergenic fusions are common, which explains missing intragenic breakpoints genomebiology.biomedcentral.com/articles/10.11…
News: Blood-based biomarker can detect, predict severity of traumatic brain injury dlvr.it/RbDXll
Pubmed: Single-molecule regulatory architectures captured by chromatin fiber sequencing. dlvr.it/RZW1ST
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The EMBO workshop "Chromatin dynamics and nuclear organisation in genome maintenance" will take place online from December 7-10, 2020. Check out our fantastic list of speakers and register before November 30, 2020 at meetings.embo.org/event/20-chrom…. Please RT
My lab is looking for a #postdoc in computational biology/genetics, jointly supervised with Matthew Stephens @mstephens999). See the ad: forms.stat.ufl.edu/statistics-job… Please RT!
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My lab is looking for motivated postdocs with RNA biology OR membrane trafficking background to study cross-kingdom RNAi and extracellular vesicle-mediated RNA trafficking. Please email your application materials to [email protected] (Please RT)
DNA methylation mediated downregulation of histone H3 variant H3.3 affects cell proliferation contributing to the development of HCC dlvr.it/RXQGPP
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The EMBO workshop "Chromatin dynamics and nuclear organisation in genome maintenance" will take place online from December 7-10, 2020. Check out our fantastic list of speakers and register before November 30, 2020 at meetings.embo.org/event/20-chrom…. Please RT
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Join us this Friday (5/29) at 9am PDT, for Dr. Bing Ren's talk on unraveling the mysterious role of non-coding regions in gene regulation. Open to all. @HargreavesLab,@activemotif, @SBPdiscovery, @CEpigenomics
I think we'll set a record for "journal to classroom" here - I'll teach this TODAY to 1st yr graduate students after describing the famous Findlay @JShendure 2014 Nature paper on doing this to DBR1 in mammalian cells (Fig 2b below). @PhilDespres @nzmyachie H/t @doyonlab
Join us this Friday (5/29) at 9am PDT, for Dr. Bing Ren's talk on unraveling the mysterious role of non-coding regions in gene regulation. Open to all. @HargreavesLab,@activemotif, @SBPdiscovery, @CEpigenomics
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