Alex Leaf
@Alexleaf
MS Nutrition | Researcher 10+ Years | Scientific Communicator
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The cure for most cases of type 2 diabetes (T2DM) requires fat loss. This thread will discuss research showing restoration of carbohydrate tolerance in those with T2DM through addressing the underlying pathology (ectopic fat) rather than just focusing on symptom management.
Trying to work and he's over here trying to get me to play with him. I obliged, of course, because look at him 😅
What’s revealing here is the assumption that all male behavior is organized around sexual access and external validation. Maybe for some. But I don’t believe for a second that *all men* operate this way. That assumption is exactly where the misuse of “simp” comes in too, and…
Editor's note: None of this actually addresses how sex is defined. You wouldn’t know which chromosomes associate with “male” or “female” unless sex were defined independently of chromosomes in the first place. Chromosomes are correlates of sex, not its definition. Same with…
Sure. Sex=Bimodal Sex≠Binary Genotypic sex is strictly defined by karyotype. XY is male, XX is female. There are chromosomal aneuploidies that violate this "binary". So genotypically, sex is not binary. It is bimodal for sure, but not binary. Phenotypic sex is most…
I have to wonder what evidence would convince Ian otherwise, because the errors in his beliefs have been empirically and logically demonstrated to him numerous times, but he continues to double-down.
I don't "believe" anything. Sex is not binary. It's not binary genotypically. It's not binary phenotypically. And it never will be. I have no political or emotional feeling about that, it is simply a fact...
The linked study shows an average weight loss of 10 kg, with 20% not achieving remission (primarily those who have had diabetes for decades, so likely pancreatic damage). Rates of remission were also predicted by extent of weight loss.
And yet, time after time in our UK NHS clinic we see significant average improvements in diabetes control and 155 cases of drug free remission by reducing dietary carbohydrates. or ‘just avoid the foods that put your blood sugar up’ Our work has been cited over 700 times now.…
This shit is real annoying because I’ve been a paid writer for years. Long before anyone was arguing about AI, I was publishing articles, getting paid, and having my work live on multiple websites. Same for my husband. This is literally how we make our money (writing and…
No no, this is excellent. Imagine you are severely allergic to something like pollen. If you had to choose between avoiding all pollen or taking a bunch of drugs to manage symptoms, you would probably go with avoidance whenever possible. But what if there was a third option…
Why Treating Carbs Like An Allergy Changes Everything If you can’t metabolize something safely, managing the symptoms isn’t the solution. #MetabolicHealth #NutritionScience #DiabetesDiscussion #LowCarb #HealthEducation #PreventiveHealth #FoodAndHealth
This is a great example of why distinguishing between proximal and ultimate causes is important. “Excess calories cause obesity” is true. A chronic energy surplus is the proximal cause of fat gain and, over time, obesity. It’s the final common pathway through which everything…
"Excess calories cause obesity" is as useful as a financial advisor saying "to get rich, earn more than you spend" How this passes as science is bewildering
I have a strong suspicion that the diet will be successful, on average, for these autoimmune diseases because this is basically an extreme elimination diet (and the zero carbs will at least transiently raise cortisol to have an immunosuppressive effect). There's a lot of…
HUGE NEWS: we are officially launching a large random clinical trial study on the ketogenic and carnivore (Lion Diet specifically) and its impact on RA and IBD! I have been working towards this and wanting it for 8 years since the carnivore diet put my Juvenile Idiopathic…
This actually serves as a great example of why any focus on extending lifespan in exclusion of body/mind functionality is insane. Very few want to live a long life filled with physical dependency and mental exhaustion. A life full of vitality is what we should focus on.
Massive new @Nature study: castration increases lifespan across vertebrates (zoo mammals, rodents, wild animals). This aligns with historical human data: Korean eunuchs lived 14-19 years longer than their peers. Your move, @Bryan_Johnson.
Editor's note: Sex is binary in that there are only two gametes from which sex is defined. Secondary sex characteristics are largely bimodal, but those are irrelevant to defining an organisms sex. Chromosomes are genetic sex determinants, but they don't define sex.
The frequency doesn't is not what matters. I know this bruises your narrative and hurts your privileged feelings. XY/XX is not the "rule". Its the AVERAGE. Sex is BIMODAL Sex is not BINARY A clear distinction...
A cool new study was published this month that gives us deeper insights into the plant vs. animal protein debate (PMID: 41059835). It showed that a plant-based protein powder worked just as well as whey for building muscle and strength during resistance training. BUT, this soy…
Kind of crazy that the US is the only major country to believe that free speech is a right independent of governance, while other countries think it is a right granted by government. We see this play out every day.
I use this platform primarily for discussion and a way for me to formulate, refine, and communicate my beliefs. When I quote someone, it’s because their post raises an idea that deserves a closer look, a rebuttal, or some added context for everyone following along. I don't care…
I agree with the push for better precision medicine. I think such a future will be invaluable. But the way NNT is being used in this post is a gross misrepresentation. NNTs for the top 10 drugs come almost entirely from short trials, usually 2 to 5 years, while people live with…
Energy surplus is the proximal cause for obesity. Calorie intake is a variable we can manipulate with great precision to cause predictable changes in body mass. The practical utility of CICO is debatable, but the biological mechanisms are well-established.
Editor's note: babies enter ketosis rapidly due to extraordinarily high energy requirements. They require ~100 kcal/kg during the first 6 months of life, which is 2-3 times higher than competitive athletes. About 40% of breast milk calories come from carbohydrates.
"Ketosis is a starvation state! Your body only does it in emergencies!" Humans are born in ketosis. Newborn babies, literally fresh out of the womb, are in deep ketosis. Breast milk is designed to keep them there: 60% fat, moderate protein, low carb. If ketosis was an…
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