Chen Chang
@ChenChangccc
Postdoc at Department of Pathology, UT Southwestern Medical Center. 'The mountain is there⛰️'.
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In vivo CAR-T cell therapy nature.com/articles/s4157… rdcu.be/eI7zH This new Review discusses how technological advances that remove the need for ex vivo manipulation and chemotherapeutic conditioning could enable wider application of CAR-T cell therapies
Microsystem technologies for accelerating the discovery and translation of immunotherapies nature.com/articles/s4157… rdcu.be/eGqYy This new review describes how microsystems can address efficacy, toxicity, predictability and affordability challenges with immunotherapies
#Googletoday Learning about DNA #GoogleDoodle g.co/doodle/q3twree g.co/doodle/q3twree…
Online Now: Genome-wide CRISPR screens identify critical targets to enhance CAR-NK cell antitumor potency dlvr.it/TMcpzz
Tumour-associated vasculature in T cell homing and immunity: opportunities for cancer therapy bit.ly/4eztEqL
For readers interested in CAR-T cell therapies in cancer immunotherapy, this Review in the May issue discusses management of toxicities and reviews druggable targets and cellular engineering strategies to develop safer CAR-T cells nature.com/articles/s4157… rdcu.be/em0rW
Off-the-shelf CAR-NKT cells for cancer immunotherapy are advanced toward clinical translation go.nature.com/4akbFkj rdcu.be/efeUJ
New Online! Nuclear and genome dynamics underlying DNA double-strand break repair bit.ly/3XTwXlu
Information storage across a microbial community using universal RNA barcoding go.nature.com/440gL5E
Worked on this for a long time and happy to publish what is hopefully just the beginning stages of an interesting sub-field of brain metastasis research! Thank you to @SZhang_Lab, co-authors and labmates🤓🍀🤠 @NDBios @UTSWCancerBio tinyurl.com/yh6wb9wt
New findings from @MITBiology suggest that the control of RNA splicing, a process that is fundamental to gene expression, is more complex than previously known buff.ly/w9RQOfx
In a follow-up of a phase 1 trial of a first generation CAR-T cell therapy in patients with neuroblastoma, 1 patient has had a sustained clinical response for over 18 years without requiring any additional therapy @MDKevinCHLi, @CAGTHouston @bcmHouston nature.com/articles/s4159…
In a first-in-human phase 1 trial, HER2-specific CAR-macrophages were feasible to manufacture and well tolerated with no dose-limiting toxicities in patients with HER2-overexpressing solid tumors nature.com/articles/s4159…
Findings from @MITBiology suggest that the control of RNA splicing, a process that is fundamental to gene expression, is more complex than previously known news.mit.edu/2025/mit-biolo…
Genome editing with the HDR-enhancing DNA-PKcs inhibitor AZD7648 causes large-scale genomic alterations go.nature.com/3D2e4Fh
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