The Amit Choudhary Lab
@ChoudharyLab
Chemical biology, CRISPR and beta-cell biology @ Broad Institute | Harvard Medical School | Brigham and Women's Hospital
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Demis -- I think AlphaFold3 is really exciting. As Reviewer #3, I got great results from the server. I tried hard to get @Nature to urge you to release the code but was unsuccessful. I did not get it for re-review so I don't know if you responded. So why no code? @GoogleDeepMind
Thrilled to announce AlphaFold 3 which can predict the structures and interactions of nearly all of life’s molecules with state-of-the-art accuracy including proteins, DNA and RNA. Biology is a complex dynamical system so modeling interactions is crucial blog.google/technology/ai/…
Thankful for this recognition. All credits go to my group's past and present members; I have been truly fortunate to work with them!
Congratulations to the winner of the 2024 Bioconjugate Chemistry Young Investigator Award, Professor Abhishek Chatterjeee, Boston College. #chemistry #award @BostonCollege @AChemSynBio @ACSPublications tinyurl.com/my3a3jxk
We got a story, and it’s electric! 🔌⚡️ rdcu.be/dth70 Can electrocatalysis be used to precisely modify a protein? Yes! Happy to finally share this work led by @conor_loynd and @SinghaSoumya. A 🧵 #ProteinElectrochemistry #NSFfunded
The first in vivo base editing clinical trial outcomes are now reported, following last year’s positive ex vivo base editing clinical outcomes! Congratulations to @kiranmusunuru , @skathire, @ambellinger, @NicoleGaudelli, & other scientists at @VerveTx and @BeamTx on these…
The culmination of 10+ years of work to use #CRISPR gene editing to fight heart disease! @ambellinger @VerveTx $VERV presenting the interim data from the ongoing heart-1 Phase 1b clinical trial of VERVE-101 base editing for HeFH patients, at #AHA23 now. Let’s start! 🧵
New @biorxivpreprint from our lab by @Qian37774492 on a covalent 14-3-3 molecular glue with the transcription factors YAP and TAZ and using this glue as a 14-3-3 recruiter to sequester nuclear neo-substrates into the cytosol! Thanks to #AppleTreePartners & @themarkfdn…
Happy to share our most recent contribution coupling covalency with carbohydrate binding for immune proximity induction. pubs.acs.org/doi/full/10.10…
I worry that this organization will put more pressure on reviewers to focus on the details and put even less focus on creativity and impact. That already seems to be an issue that was not addressed with these changes.
Anyone who writes or reviews NIH grants will want to read this: nexus.od.nih.gov/all/2023/10/19…
Thrilled to share my primary PhD work: a Transcription Factor Atlas for understanding gene regulation and cell engineering @CellCellPress. We created a comprehensive TF ORF library and applied it to profile resulting expression changes. A thread 1/X sciencedirect.com/science/articl…
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