Anthony Rullo: chemically modulating proximity
@LabRullo
Covalent and multivalent - proximity inducing strategies for basic and translational chemical biology
Bạn có thể thích
A new generation of radiotherapies promises a more targeted attack on cancer. Learn more: scim.ag/3IACb1i @NewsfromScience
How to make immune cells “invisible” to facilitate allogeneic cell therapies? MIT and Harvard Build “Invisible” Immune Cells That Obliterate Cancer scitechdaily.com/mit-and-harvar…
Happy to share my lab’s work out today in @Cancer_Cell demonstrating that multiple myeloma relapses after CAR T therapy frequently express low BCMA levels. We develop novel SEMA4A-directed CAR T cells eradicating MM, especially under BCMA low conditions. authors.elsevier.com/a/1lvYf_YwcvnX…
Controlling the 3D structure of #glycans allows increased binding to proteins- not just a curiosity but a powerful concept to develop better #vaccines
Stapling of β-Glucans Increases Antibody Binding | Journal of the American Chemical Society @peterseeberger @MpiciPotsdam @FU_Berlin pubs.acs.org/doi/10.1021/ja…
Folding-mediated secretion of pure bispecific antibodies go.nature.com/48NEM2o
Today's Nobel Prize for Physiology or Medicine relates to research on regulatory T cells nobelprize.org/prizes/medicin… For readers interested in harnessing the biology of regulatory T cells to treat disease, here's a comprehensive review nature.com/articles/s4157… rdcu.be/eJHU8
Immunology takes center stage again at the #NobelPrize! Congratulations to Mary Brunkow, Fred Ramsdell & Shimon Sakaguchi for uncovering how regulatory T cells maintain immune tolerance—a discovery that transformed our understanding of autoimmunity and cancer immunotherapy
How many faces do you see?
Frustration in the protein-protein interface plays a central role in the cooperativity of PROTAC ternary complexes nature.com/articles/s4146…
The fusion of intrinsically disordered regions to CARs enhances CAR-T signaling by inducing CAR condensation and enhances CAR sensitivity to low-antigen-expressing cancer cells nature.com/articles/s4158…
It has been a particular joy to develop the family of tr-FPs with my group. All authors are greatly appreciated, and we thank @CellCellPress for publishing this work. Plasmids are available via WekwikGene, and we hope you enjoy imaging in the temporal and spectral domains!
Now online! Time-resolved fluorescent proteins expand fluorescent microscopy in temporal and spectral domains dlvr.it/TNGGY5
Congrats to my graduate student Dave Leace and team on the new paper! They discovered a ligand-induced protein tethering (LIPT) molecular glue mechanism — revealing new PPIs, altered protein localization, and disrupted cancer metabolism. pubs.acs.org/doi/full/10.10…
pubs.acs.org
A Glutathione S-Transferase Pi Molecular Glue Tethers Splicing Factors and Remodels Cell Metabolism
Here, we discovered a tyrosine-reactive GSTP1 inhibitor can function as a molecular glue via a ligand induced protein tethering (LIPT) mechanism. Electrophilic modification of GSTP1 results in...
Huntington's disease has been successfully treated for the first time, doctors tell BBC bbc.in/46jnMiX
kendrick v drake for physical organic chemists
Rational design of the linkers in targeting chimeras - now published in Chemical Science pubs.rsc.org/en/content/art…
Hydration (H2O and D2O) Dictates the Stabilities and Conformational Entropy of Transthyretin Tetramers | Journal of the American Chemical Society @TAMUChemistry @TAMU pubs.acs.org/doi/10.1021/ja…
Design, Synthesis, and Biological Evaluation of Arginine N-Glycosylation Stapled Peptides with Potent Antitumor Activity In Vivo | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/ac…
Our group's newest preprint! @EvelineTiekink and @YumanHordijk reveal that Lewis acids prefer σ-binding to lone pairs rather than π-binding to double bonds, with implications for chemical bonding and reactivity! Great work by the team! 🔍💻🧪 doi.org/10.26434/chemr…
Discovery of Macrocyclic Peptide Binders, Covalent Modifiers, and Degraders of a Structured RNA by mRNA Display | Journal of the American Chemical Society @UChicago @UChiChemistry @czbiohub pubs.acs.org/doi/10.1021/ja…
United States Xu hướng
- 1. Branch 37.4K posts
- 2. Chiefs 112K posts
- 3. Red Cross 54.5K posts
- 4. Lions 89.7K posts
- 5. #njkopw 8,582 posts
- 6. Exceeded 5,859 posts
- 7. Binance DEX 5,154 posts
- 8. Mahomes 34.9K posts
- 9. Rod Wave 1,674 posts
- 10. Air Force One 58.2K posts
- 11. #LaGranjaVIP 83.6K posts
- 12. Eitan Mor 17.8K posts
- 13. #LoveCabin 1,390 posts
- 14. Ziv Berman 20.9K posts
- 15. Alon Ohel 18.3K posts
- 16. #TNABoundForGlory 60K posts
- 17. Tel Aviv 60.1K posts
- 18. Matan Angrest 16.5K posts
- 19. Knesset 14.3K posts
- 20. Omri Miran 16.6K posts
Bạn có thể thích
-
bryan dickinson
@chembioBryan -
Woo Lab
@thewoolab -
Guillaume Laconde
@Glaconde34 -
Matt Disney
@disney_lab -
Katherine A Donovan
@kdonovan1008 -
Jeremy Baskin
@basktastic -
Ruben Ragg
@RubenRagg -
Chris Parker
@_chrisgparker_ -
Kiessling Group
@KiesslingGroup -
Lyn Jones
@LynJonesChemBio -
Radek Nowak
@RPNowak -
Abhishek Chatterjee
@AChemSynBio -
Trader Lab
@DJTraderLab
Something went wrong.
Something went wrong.