Pharmacological Sciences
@DPS_ISMMS
The DPS focuses on the biological mechanisms underlying complex physiology and pathophysiology, and translating biological knowledge into new therapeutics.
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Thrilled to co-host, alongside colleagues Drs. David Thomas and Michael Leitman, the inaugural symposium "AI in (Bio)Medical Education: Innovation in Teaching and Learning". Looking forward to a stimulating afternoon with @GradSchoolSinai and @IcahnMountSinai teaching faculty.
Join us on Thur. July 24 @ 2 PM ET for a virtual seminar about ChEA-KG, a newly developed @MaayanLab web-based app that enables users to analyze their gene sets in context of a human gene regulatory network (1559 transcription factors). Please register at maayanlab.cloud/turl/35e9d6a0
Excited to see our new AI Small Molecule Drug Discovery Center @IcahnMountSinai featured in GEN! 🧬🧠 Read more: genengnews.com/topics/artific… Thank you @xiaofei_lin and @GENbio #AI #DrugDiscovery #Genetics
genengnews.com
Democratizing Artificial Intelligence in Pre-Clinical Drug Discovery
While AI-driven approaches tout increased speed and lower costs, commercial interests compromise scientific collaboration.
Drs. Rechkoblit, Aggarwal & coauthors @DPS_ISMMS & @gangfang_1 unveil the structure of bacterial CBASS effector Cap5 degrading DNA, triggering bacterial self-destruction. External activation of Cap5 offers potential antibiotic strategy. @NatureComms bit.ly/40473611
Amazing work by Dr. Rechkoblit et al. from the Aggarwal and @gangfang_1 Labs on CBASS Cap5 endonuclease showing bacterial self-destruction by digesting its own DNA! Congratulations! 👏 Happy to be part of this study. urldefense.proofpoint.com/v2/url?u=https…
Genes in cells are a bit like words, and gene sets are like sentences b/c genes are reused in different contexts; To learn the language of the cell, @MaayanLab developed: A #GeneSet #FoundationModel Pre-Trained on a Massive Collection of Diverse Gene Sets biorxiv.org/content/10.110…
New lab picture: @filizolalab1 on the relentless quest for breakthrough science to build a brighter future. Bring it on!
FRESH OFF THE PRESS @filizolalab1 : Fine-Tuned Deep Transfer Learning Models for Large Screenings of Safer Drugs Targeting Class A GPCRs | Biochemistry pubs.acs.org/doi/full/10.10…
We are proud to share new exciting findings from the @Proteomics_Shi & Garcia-Sastre Lab. They have developed a novel antibody platform called AMETA. This platform harnesses multi-epitope targeting and avidity to combat viral mutational escape effectively. mountsinai.org/about/newsroom…
We are pleased to share a collaboration of the Aggarwal, Fang, @filizolalab1, and Shapiro Labs publication in @NatureComms! nature.com/articles/s4146…
Excited to share our first cryo-EM paper, which was just published in Nucleic Acids Research: academic.oup.com/nar/advance-ar… We investigate a new family of RNases with crystal and cryo-EM structures. Congrats Ruoxi!
New in @JPET_Journal: We show endogenous and small molecules like CBD act as chaperones modulating levels of Cannabinoid, Delta Opioid receptors and their interacting complexes with therapeutic implications for pathologies involving these receptors tinyurl.com/mv7duj6w
From @AviMaayan, @PeiMSSM2016, and colleagues: Multiomics2Targets identifies targets from cancer cohorts profiled with transcriptomics, proteomics, and phosphoproteomics: Cell Reports Methods cell.com/cell-reports-m… @IcahnMountSinai
Excited to share our new study in collaboration with @gpandeylab where we explore the conformational space of protein kinases using AI-generated structures. Led by @NoahBHerrington with contribution from @david_stientist and @rlychuh #alphafold #kinase dx.plos.org/10.1371/journa…
Join our Virtual Symposium in Big #DataScience on 8/8 @ 10 AM ET where the @Maayanlab trainees in the 2024 Summer Undergraduate Research Training Program in Biomedical Big #DataScience will present their research projects. Register: mountsinai.zoom.us/webinar/regist…
Authors @jitheshkottur and @radhikaRMalik from @DPS_ISMMS report strucutres of bacterial defense system SPARTA, activated by invading DNA for NAD(P)+ hydrolysis. nature.com/articles/s4146…
Authors @jitheshkottur and @radhikaRMalik from @DPS_ISMMS report strucutres of bacterial defense system SPARTA, activated by invading DNA for NAD(P)+ hydrolysis nature.com/articles/s4146…
Happy to share @jitheshkottur @radhikaRMalik paper from the Aneel Aggarwal lab published in @NatureComms. They report structures of bacterial defense system SPARTA, activated by invading DNA for NAD(P)+ hydrolysis. nature.com/articles/s4146…
On Tuesday, June 4, Mount Sinai hosted the Institute for Medical Education’s Excellence in Teaching Award Ceremony. We are proud to announce that two of our PhD students, Pushkala Jayaraman and Richard Quintana-Feliciano, were honored at the ceremony. Congratulations!
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