Elise Flynn
@EliseScience
Computational Biologist @ Patch Bio. regulatory DNA, RNA | gene therapy | synthetic biology My ''professional'' twitter account. She/her.
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Excited to share our recent work at @Ginkgo . TLDR: high quality mRNA stability data -> performant ML models -> design 3’UTRs that increase stability -> in vivo validated ML 3’UTRs beat benchmark. biorxiv.org/content/10.110…
🚨Our work on multi-modal, single-cell pooled CRISPR screens to study GWAS variant-to-function, STING-seq, is now out in @ScienceMagazine! Read on for 6⃣ of the main findings from our study, led by myself and co-advised by @nevillesanjana and @tuuliel! 🎉 science.org/doi/10.1126/sc…
Our newest chapter is out @nature! - Bestrophin-2 and glutamine synthetase form a complex for glutamate release nature.com/articles/s4158…
Maya Bose from @theparkerlab with a talk about position-dependent effects of regulatory elements in an MPRA. Many TFBSs had larger effect upstream of promoter vs. downstream (including E2F, ETS), and activity was heavily biased for the forward strand #ashg22
Great meeting of the @GeneticsSociety Program Committee! It was an intense 1.5 days but we have an exciting program coming up for you. See you all in Los Angeles in October.
Which transcription factors (TF) regulate which #genetic variants? Flynn et al analyze eQTL effect size as a function of TF level, & find candidate TF mechanisms for a large number of eQTLs @EliseScience @tuuliel_lab @Pejminister @nygenome doi.org/10.1371/journa…
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