Ghobrial Lab
@LabGhobrial
We research hematological malignancies and their precursor conditions. Profile image created with http://BioRender.com
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Exciting work from our lab out last week in @NatureComms: Single-cell RNA sequencing defines distinct disease subtypes and reveals hypo-responsiveness to interferon in asymptomatic Waldenstrom’s Macroglobulinemia @Yoshi_konnykid @IrenemGhobrial @getz_lab @DanaFarberNews
Let's walk through what we found in our new study using single-cell RNA-seq on tumor and immune cells from pts w/ asymptomatic Waldenstrom's Macroglobulinemia - out now in @NatureComms! W/ @Yoshi_konnykid @IrenemGhobrial @gaddyg #wmsm #mmsm nature.com/articles/s4146… 1/
🎥 At #IMS2024, Elizabeth Lightbody of @DanaFarber discussed SWIFT-Seq, a novel method utilizing single-cell RNA sequencing of CTCs in patients with MGUS, smoldering #Myeloma, & newly diagnosed #MultipleMyeloma. Watch here: 👉 ow.ly/FMKP50UgEPn 👈 #MMSM #CaGenome #HemOnc
vjhemonc.com
SWIFT-Seq: single-cell RNA sequencing of CTCs for patients with multiple myeloma and precursors
Elizabeth D. Lightbody, PhD, Dana-Farber Cancer Institute, Boston, MA, discusses SWIFT-Seq, a novel method utilizing single-cell RNA sequencing of circulating tumor cells (CTCs) in patients with...
Nayda and Francesco presenting our immune profiling data in smoldering and released myeloma with teclistamab therapy. #ash24 #mmsm
Kudos to @IrenemGhobrial @LabGhobrial for the amazing work presented at #ASH24 Always pushing technology to the next level and bringing new insight in myeloma #mmsm My favorite: the use of imaging mass cytometry to understand CRS, hematotoxicity and survival after CAR T therapy
Thrilled to present our award achieving abstract on longitudinal single-cell immune profiling of patients with HRSMM and RRMM receiving Teclistamab at #ASH24. Thankful to my mentor @IrenemGhobrial and everyone at Ghobrial lab for the support. @DanaFarber @ASH_hematology #mmsm
This Startup Raised $5.2 Million To Develop Blood Tests For Cancer #mmsm. We are excited to launch Predicta Bio for myeloma patients forbes.com/sites/jacobwen…
Today, the FNIH Biomarkers Consortium announces the launch of a significant project to develop and validate blood-based biomarkers for predicting progression to multiple myeloma. This collaborative initiative brings together critical resources and stakeholders from the public…
Agenda - IBC. Amazing group of scientists are meeting next week to discuss early detection and interception of blood cancers. Join us virtually if you can #ibc24 #mmsm @DanaFarber ibcworkshop.org/agenda/
In contrast to our previous study of #CHIP in #multiplemyeloma which was in a different era, we now report good outcomes even in those with #myeloma and #CHIP in the era of novel agents. Yet, there is an accelerated increase in the incidence of CHIP while on #mmsm treatment.
Just published: Clinical outcomes and evolution of #clonalhematopoiesis in patients with newly diagnosed #multiplemyeloma, by @tarekmd91 et al. bit.ly/47AGsce @IcahnMountSinai #openaccess
Get to Know… Irene Ghobrial, MD bloodcancerstoday.com//post/get-to-k…
#ASH23🩸Such a great experience to finally share my IRF4 inhibitor story! Great meeting new colleagues, old friends…and you can’t beat the 🌞 in San Diego 🙌🏾! @IrenemGhobrial @JunQiLab @SiranoDhePagano
@lizlightbody presenting our data on circulating tumor cells in MGUS and SMM #ash23 #mmsm
Stay tuned for more on this exciting work from @LabGhobrial !
@lizlightbody presented our proteomics data demonstrating new biomarkers of disease progression #ash23 #mmsm
Great to gather with team colleagues and friends at DFCI party in San Diego!
We are excited to launch our new Centers for Early Detection and Interception. Designed for individuals with an increased risk of developing cancer, we will focus on detecting cancers sooner and stop them from developing. dana-farber.org/newsroom/news-…
Only with @IrenemGhobrial would I ever for a moment consider it possible to pull together an entire scientific conference in 3 weeks 🤯 Inaugural Center for Early Detection and Interception of Blood Cancers Scientific Retreat was a success! Already planning next year 😊
@ken anderson talking about endpoint for interception in blood cancers. @Lachelle_Dawn was an outstanding leader of the retreat. #center of early detection and interception of blood cancers #CEDI-BC.
Physician-scientist @IreneGhobrial speaks about how her multidisciplinary team works hard and fast to address health disparities in bone-marrow cancer @DanaFarber. Interview by @francesgatta go.nature.com/3pIaMAJ
Our study evaluating TR-FRET based serological assays is published now @CellRepMethods! How is it done and what have we found? A thread 1/N #FRET #Serology cell.com/cell-reports-m…
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