Peng Jiang Lab
@LabJiang
create hPSC #organoid brain & #chimeric brain models to study #neurodevelopment, #aging, #DownSyndrome, #Alzheimers, & #Autism; develop glia replacement therapy
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Returned to this platform to amplify this beautiful work! Well done Sonia and all! A major step forward and key experimental insights for how we advance this for many diseases.
Microglia replacement via vascular delivery and no toxic preconditioning? Now THAT is something I can get excited about. In our new paper we find that microglia replacement can now be achieved by peripheral delivery w/ no irradiation or chemo required. 👉 doi.org/10.1016/j.ymth…
We are pleased to share our newest publication from the @BlurtonJonesLab, "CSF1R inhibitor-resistant model for CNS-wide microglia replacement strategies" sciencedirect.com/science/articl…
We are excited to announce the 3rd ASCN Symposium, Jan 28-30, 2026 in Houston! Featuring a keynote by Dr Hongkui Zeng @HongkuiZeng @AllenInstitute and 10 exciting sessions. Join us for cutting-edge talks, trainee award & networking! Register at sfnchinese.org
Nobel Laureate Professor Sir John Gurdon dies aged 92 | University of Cambridge cam.ac.uk/research/news/…
"Overall, however, there is little indication of chimera technology blurring the line between humans and animals, and thus of the technology causing moral confusion." link.springer.com/article/10.100…
link.springer.com
Will Human-Animal Chimeras Cause Moral Confusion? Exploring Public Attitudes
Journal of Bioethical Inquiry - Recent medical research involving human-monkey chimeras, human brain organoids in rats, and the transplantation of a gene-edited pig heart and gene-edited pig...
Rare post-mortem brains of so-called “resilient” subjects are defined as having ample amyloid plaques and tangles but no dementia at death. The reason, every time? Absence of neuroinflammation! Amyloid causes tangles, which cause neuroinflammation, without which, no Alzheimer’s!
If neuroinflammation is the problem why aren’t Alzheimer’s brains swollen rather than atrophied? Tau tangles clearly correlate with symptoms but how are they toxic? Neuronal loss and cortical atrophy are due to microtubule depolymerization, reversed by Transcranial ultrasound.
Microglia replacement halts the progression of microgliopathy in mice and humans | @ScienceMagazine science.org/doi/10.1126/sc…
The Somatic Mosaicism across Human Tissues Network | Nature nature.com/articles/s4158…
TET2-mutant myeloid cells mitigate Alzheimer’s disease progression via CNS infiltration and enhanced phagocytosis in mice: Cell Stem Cell cell.com/cell-stem-cell…
The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway: Immunity cell.com/immunity/fullt…
🧩Today is #AutisticPrideDay! Up to 18% of people w/#DownSyndrome also have #Autism. At GLOBAL we're committed to supporting & celebrating people w/the dual diagnosis like our brilliant #GLOBALAmbassador, Micah Quinones! Watch his AMAZING story here: bit.ly/3HLHEBu
Senescence-resistant human mesenchymal progenitor cells counter aging in primates: Cell cell.com/cell/fulltext/…
p16-expressing microglia and endothelial cells promote tauopathy and neurovascular abnormalities in PS19 mice: Neuron cell.com/neuron/fulltex…
Online now: Chimeric brain models: Unlocking insights into human neural development, aging, diseases, and cell therapies dlvr.it/TKQfYD
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