LabLappalainen's profile picture. Mechanistic insights into actin cytoskeleton, cell migration and mechanobiology with structural biology, biochemistry and cell biology. @HelsinkiUni @BiotechUH

Lappalainen lab

@LabLappalainen

Mechanistic insights into actin cytoskeleton, cell migration and mechanobiology with structural biology, biochemistry and cell biology. @HelsinkiUni @BiotechUH

Lappalainen lab reposted

Registration open - amazing program with the latest on #ecm #mechanobiology #adhesion #cytoskeleton #microscopy #structure and more! Join us and spread the word! @TanentzapfLab

@WickstromLab & myself are happy to announce the program for the upcoming Fibronectin, Integrin & Related Molecules Gordon Research Conference. This is one of the oldest GRC conferences around (since 1982) & we put together an OUTSTANDING program for y'all. Registration is open.

TanentzapfLab's tweet image. @WickstromLab & myself are happy to announce the program for the upcoming Fibronectin, Integrin & Related Molecules Gordon Research Conference. This is one of the oldest GRC conferences around (since 1982) & we put together an OUTSTANDING program for y'all. Registration is  open.


Lappalainen lab reposted

@WickstromLab & myself are happy to announce the program for the upcoming Fibronectin, Integrin & Related Molecules Gordon Research Conference. This is one of the oldest GRC conferences around (since 1982) & we put together an OUTSTANDING program for y'all. Registration is open.

TanentzapfLab's tweet image. @WickstromLab & myself are happy to announce the program for the upcoming Fibronectin, Integrin & Related Molecules Gordon Research Conference. This is one of the oldest GRC conferences around (since 1982) & we put together an OUTSTANDING program for y'all. Registration is  open.

Lappalainen lab reposted

Our recent published paper from my pre-PhD training at @WUMIN_LAB! Shoutout to our reviewers for their constructive suggestions that strengthened our story and helped us uncovered details that we almost overlooked! #actin cell.com/cell-reports/f…

cell.com

Competition and synergy of Arp2/3 and formins in nucleating actin waves

Chua et al. showed that multiple actin nucleators are assembled in cortical actin waves. Their mutual dependency leads to the fine-tuning of actin and the upstream signal transduction networks on the...

The moment I've been waiting for, to showcase the direct visualization of actin nucleators and their cooperative yet competitive assemblies in the #actin cytoskeletal network!! Check out some of our videos below and supplementary files biorxiv.org/content/10.110…



Lappalainen lab reposted

Work by @Romet_Jegou_lab (hubs.la/Q02xg06X0) provides a detailed in vitro analysis of the steps involved in fragmenting fascin-bundled #actin filaments & proposes a novel mechanism for severing two-filament bundles. Spotlight from Kadzik & Kovar: hubs.la/Q02xg3zQ0

JCellBiol's tweet image. Work by @Romet_Jegou_lab (hubs.la/Q02xg06X0) provides a detailed in vitro analysis of the steps involved in fragmenting fascin-bundled #actin filaments & proposes a novel mechanism for severing two-filament bundles. Spotlight from Kadzik & Kovar: hubs.la/Q02xg3zQ0

Lappalainen lab reposted

Interested in cutting edge cell adhesion research? @IvaskaLab @DibusMichal @Omkar_Joshi_ new COCB review highlights the coolest and newest approaches👇! Novel tools to study cell-ECM interactions, cell adhesion dynamics and... sciencedirect.com/science/articl…


Cool stuffs. Phospholipids have always been overlooked.

Periodicity, mixed-mode oscillations, and multiple timescales in a phosphoinositide-Rho GTPase network dlvr.it/Sspm66



Lappalainen lab reposted

Recent work @WUMIN_LAB is now up on Cell Reports!

Periodicity, mixed-mode oscillations, and multiple timescales in a phosphoinositide-Rho GTPase network dlvr.it/Sspm66



Our visiting scientist (to-be, not just A-B #punintended) gave us such a wonderful presentation that we are not going to have a next one until Autumn begins. Hyvää Juhannusta! Happy Midsummer!

LabLappalainen's tweet image. Our visiting scientist (to-be, not just A-B #punintended) gave us such a wonderful presentation that we are not going to have a next one until Autumn begins.

Hyvää Juhannusta! Happy Midsummer!
LabLappalainen's tweet image. Our visiting scientist (to-be, not just A-B #punintended) gave us such a wonderful presentation that we are not going to have a next one until Autumn begins.

Hyvää Juhannusta! Happy Midsummer!

Lappalainen lab reposted

🔬 New research from @LabLappalainen @helsinkiuni in collaboration w/@AICJanelia reveals 2 new nanoscale layers within focal adhesions -- structures that connect cells to their surroundings – that are critical for focal adhesion turnover. 🧵 (1/7) 🔗biorxiv.org/content/10.110…


Lappalainen lab reposted

Postdoctoral position(s) available in @IvaskaLab ! Apply by end of April if you are interested to 1) explore stroma-cancer crosstalk in breast cancer invasion (see flyer) or 2) to explore RTK trafficking and therapeutic antibody efficacy with @klauselenius

johannaivaska's tweet image. Postdoctoral position(s) available in @IvaskaLab ! Apply by end of April if you are interested to 1) explore stroma-cancer crosstalk in breast cancer invasion (see flyer) or 2) to explore RTK trafficking and therapeutic antibody efficacy with @klauselenius

Lappalainen lab reposted

cell.com/cell-reports/f… Our Cryo-EM structures of non-muscle actin.tropomyosin assemblies. Previously available in @bioRxiv, now also in @CellReports


If you see the actin monomers falling off, it’s not a bad sign. It’s just actin disassembly. #PunIntended 🥁 P.S. here’s our logo, correspondence to @reenak52086225

LabLappalainen's tweet image. If you see the actin monomers falling off, it’s not a bad sign. It’s just actin disassembly. #PunIntended 🥁 P.S. here’s our logo, correspondence to @reenak52086225

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