Moraga Lab
@LabMoraga
The Moraga group studies cytokines and their central role in immune regulation. We combine protein engineering, structural biology & immunology in our research
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After a hard year, I’m glad to see this finally over the line. A real team effort from @YiboJin @scott_d_gardner @TomasVoisin and others from @LabMoraga. As always, amazing data collection support @eBIC_Diamond #cryoem nature.com/articles/s4146…
Disease-associated variant in IL6ST gene encoding for gp130 led to increased flexibility including motion within the cytokine-binding core (IL-6 and IL-11) and increased distance between extracellular domains nature.com/articles/s4146…
Excited to share our newest full collaboration with @BubeckLab. We provide structural insights that help explain how mutations in gp130 that do not disrupt cytokine binding cause signaling defects and immunodeficiencies in humans. doi.org/10.1038/s41467…, @UoDCellSigImm
🚨2 Yr Postdoc Available🚨 Jointly supervised with @scienceadvocacy working on normal and pathological HSCs, cytokines, malignancy, clonal expansion. Come and join us at the newly-formed @CBR_UoY @YBRI_UoY Apply here 👇👇👇jobs.york.ac.uk/vacancy/post-d… Pls retweet and DM!
Differential functional coupling in Gp130-JAK complexes expands the plasticity of the interleukin-6 signaling axis biorxiv.org/cgi/content/sh… #bioRxiv
Ever wonder why ancestral cytokine receptors, like Gp130, bind multiple JAKs, and whether the identity of the GP130-JAK complex instructs specific responses? Check our new work, in a full collaboration with the @PiehlerLab, for some answers biorxiv.org/cgi/content/sh…
📜State-of-the-Art📜 Molecular and cellular factors determining the functional pleiotropy of cytokines 🖋️ By Alison McFarlane, Elizabeth Pohler and Ignacio Moraga from @dundeeuni 🔗 buff.ly/3pWOAme #cytokinesignalling #endosomessignalling
So excited for this session, I couldn’t sleep! Cytokines, engineering, structures, and therapies. Not a session to miss! 10:15 AM-12:15 PM room 102AB
Attending @ImmunologyAAI this week and love cytokines? @CytokineSociety: Modulating Cytokine Activity through Structural Knowledge – Saturday; 10:15 AM – 12:15 PM; Room 102AB. Organized by @DrJuanLMendoza with lots of cool cytokine engineering @SpanglerLab @Regeneron
Interested in interleukin-6 and how you can therapeutically block its pro-inflammatory activities? See our latest review, just published in @NatRevImmunol — great team work together with @Lab_Jenkins, Stefan Rose-John @kieluni and Jens Moll/Jürgen Scheller @HHU_de
Join us for the ICIS-sponsored and organized session at Immunity 2023! Learn how both academic and industry members of ICIS are advancing our understanding of cytokine biology and developing future immunotherapeutics.
Going to AAI? Please join us for the ICIS Guest Symposium "Understanding and Modulating Cytokine Activity through Structural Knowledge" @DrJuanLMendoza Saturday, May 13; 10:15 AM – 12:15 PM Eastern Time in Room 102AB cytokinesociety.org/understanding-… via @httpstwittercomCytokineSociety
Going to AAI? Please join us for the ICIS Guest Symposium "Understanding and Modulating Cytokine Activity through Structural Knowledge" @DrJuanLMendoza Saturday, May 13; 10:15 AM – 12:15 PM Eastern Time in Room 102AB cytokinesociety.org/understanding-… via @httpstwittercomCytokineSociety
NEW for 2023 on the @SciImmunology website is the dedicated CANCER IMMUNOLOGY block. 🔗➡️bit.ly/Cancer_Immuno Scroll down to it & check out 6 recent #cancerimmunology papers. More exciting new content is on the way to this space soon!
#Cancer L’acidité des tumeurs nuit à l’efficacité des thérapies anticancéreuses, selon une nouvelle étude. Des résultats qui pourraient conduire à une nouvelle génération de traitements d’immunothérapie. ➡️bit.ly/3hLyjNq
SPOTLIGHT: After showing that tumor-derived lactic acid limited IL-2 signaling, STAT5 phosphorylation, and antitumor activity in the TME, @Inserm @at_Mitralab used directed evolution to identify a pH-selective IL-2 mutein that bound IL-2Rα with [...] 👉 ow.ly/QAse50M3ptF
![ACIR_org's tweet image. SPOTLIGHT: After showing that tumor-derived lactic acid limited IL-2 signaling, STAT5 phosphorylation, and antitumor activity in the TME, @Inserm @at_Mitralab used directed evolution to identify a pH-selective IL-2 mutein that bound IL-2Rα with [...] 👉 ow.ly/QAse50M3ptF](https://pbs.twimg.com/media/FkBHRPmX0AAKPj_.jpg)
Today's #shoutout to #womeninSTEM goes to SILVIA GAGGERO for her @SciImmunology paper w/ @at_Mitralab showing IL-2 is inactivated by the acidic pH environment of #tumors enabling engineering of a pH-selective mutein. science.org/doi/10.1126/sc…
A new study looks to make IL-2 therapy more effective in tumors, presenting a variant of the cytokine that retains its binding affinity in low pH environments. Read more in @SciImmunology: scim.ag/R5
A new study looks to make IL-2 therapy more effective in tumors, presenting a variant of the cytokine that retains its binding affinity in low pH environments. Read more in @SciImmunology: scim.ag/O8
Another straightforward reason why the Warburg metabolism causes immune suppression in the TME IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein science.org/doi/10.1126/sc…
A new study looks to make IL-2 therapy more effective in tumors, presenting a variant of the cytokine that retains its binding affinity in low pH environments. Read more: scim.ag/ME @roychoudhurilab @LabMoraga @at_Mitralab @Inserm @Canther_Lille @CamPathology
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