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I am delighted to share the VetPath paper on skua and gull naturally infected with HPAI H5N1 during the summer of 2022. journals.sagepub.com/doi/10.1177/03…
Really glad to say our spatial model of HPAI (hi path avian influenza) in Europe is now preprinted! Tremendous effort from @JoeBHilton and Dr Sarah Hayes to understand which host ecology factors drive bird flu presence, where, and when. biorxiv.org/content/10.110… 🧵1/5
Do you know what makes tick- and mosquito-borne flaviviruses different? Check the newest preprint by @JiHoloubek et al. from @LabRuzek 👀📖🔬🦠 researchsquare.com/article/rs-391…
I wrote a short piece about a new flu subtype (H19) which uses a surprising receptor. We've known about glycans terminating in sialic acid as a receptor for flu for 70 years but the virus still surprises us! Great work by Karakus et al. authors.elsevier.com/a/1jPEg6t8JEqo…
Time to share that we believe to have detected transovarial transmission of USUV->important for the establishment of endemicity? Amazing collaboration between @VB_RADAR @APHAgovuk @ZSLScience @UKHSA biorxiv.org/content/10.110…
In 2023, 162 animals on 27 fox farms positive for HPAI. Many had ecrosuppurative bronchointerstitial pneumonia. Foxes and gulls in same area all had EA-2022-BB genotype and clustered together. Some mammalian adaptive mutations detected. 👉eurosurveillance.org/content/10.280…
1/4 Short message of the KAPPA-FLU Partner @Loeffler_News on the H5N1-experiments in dairy cows: As a first interim result, not only the US isolate but also a recent H5N1 virus from a wild bird in Germany was able to multiply very well in the udder. fli.de/en/news/short-…
The udder & respiratory tract of dairy cattle are rich in avian influenza virus-specific avian-type sialic acid receptors. H5N1 clade 2.3.4.4b virus has tropism for mammary epithelial cells, which explains the high viral load in contaminated milk. pubmed.ncbi.nlm.nih.gov/38861554/
H5N1: international failures and uncomfortable truths - The Lancet. Self explanatory thelancet.com/journals/lance…
Don't let your comfort zone define your expertise. Accepting challenges and working with others are ways to make you grow.
“Having expertise in multiple disciplines is my superpower.” #ScienceWorkingLife scim.ag/78k
very interesting preparing, studying persistence of infectious H5N1n virus in unpasteurised milk on surfaces used in milking. Conclusion: there is a clear risk of environmental persistence. medrxiv.org/content/10.110…
A modeling study showing the power of vaccination: "Since 1974, vaccination has averted 154 million deaths, including 146 million among children younger than 5 years of whom 101 million were infants younger than 1 year.....translating to 10·2 billion years of full health gained."
"vaccination has averted 154 million deaths" WHO launched the Expanded Programme on Immunization (EPI) in 1974 to make life-saving vaccines available to all. On the 50th anniversary of EPI, authors quantify the public health impact of vaccination: hubs.li/Q02w0Qpd0
This is dangerous and daft. Defra, which oversaw the salmonella and BSE cluster-thingies in the 90s, is conflicted. Saying we cant see evidence of it, so we are not testing makes no sense. It went undetected in the US for months before it was spotted.. telegraph.co.uk/global-health/…
Cow to cow transmission of HPAI?
"vaccination has averted 154 million deaths" WHO launched the Expanded Programme on Immunization (EPI) in 1974 to make life-saving vaccines available to all. On the 50th anniversary of EPI, authors quantify the public health impact of vaccination: hubs.li/Q02w0Qpd0
China been using vaccines to control HPAI H5 since 2004, with more than 300 billion doses used by 2022. Paper outlines suggestions regarding requirements for vaccine selection and effectiveness. 👉sciencedirect.com/science/articl…
Assessment of susceptibility of pigs to avian and mammalian HPAI H5N1 2.3.4.4b. All strains replicated in the lung of pigs w lesions consistent with influenza. But, viral replication in the nose + transmission only observed when using mammalian viruses. 👉wwwnc.cdc.gov/eid/article/30…
I asked ChatGPT for a picture of what my lab does, and it was pretty close. But we do *mechanistic* neuroscience. So let's make it more mechanistic! (a thread) 1/6
Pathology residents should be equipped with ‘imagigal light-ornoscop micorcope techniques’. 🤪
Seems like as good a time as any to share this GPT-4 image I generated using a grant abstract as the prompt. Maybe we’ll put it in paper!
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