MariaLafaille Lab
@MLafailleLab
IMMUNOLOGY OF ALLERGIES, IgE BIOLOGY AND B CEL MEMORY. Opinions are Maria's own.
Was dir gefallen könnte
Extreme budget cuts for science in Argentina can put in peril generations of scientists. nature.com/articles/d4158…
Dear Dusan and Dusanites colleagues: we will miss you big time!!! Best wishes as you move to the other side of town. @BogunovicLab
It’s been 10y since we opened our lab at @IcahnMountSinai. What an exciting ride and supportive environment it has been. We are now moving to @Columbia @ColumbiaPeds. Thrilled at the future and discoveries in genetics and immunology to come.
New work from the Victora lab (@victora_lab) explains why in secondary immunizations, new germinal centers form from naïve cells that bind poorly to the antigen. It’s all about pre-existing antibodies! nature.com/articles/s4157… biorxiv.org/content/10.110…
Results of the first stage of the NIAID funded CoFAR OUtMATCH trial, involving 10 sites including Mount Sinai (Scott Sicherer, PI) were just reported nejm.org/doi/pdf/10.105…
Important news for pediatric food allergy!! The FDA approved anti-IgE (Omalizumab) treatment to reduce reactions to accidental exposures to allergenic foods. More in nih.gov/news-events/ne….
Original Article: Omalizumab for the Treatment of Multiple Food Allergies nej.md/4bLW7aS Editorial: Options for Multiple Food Allergies — Food Avoidance or Pharmacologic Treatment? nej.md/3IaTeD7
Terrific editorial work at @ScienceTM. A great journal to send your work to!
Super cool cover for the @ScienceTM Feb 7 24 issue by Claud Spadafora and Joshua Koenig.
This week's new issue of #ScienceTranslationalMedicine has arrived! Researchers uncover stealthy immune saboteurs that drive allergic memory in humans, a new analysis in mice reveals how the brain recovers after stroke, and more. scim.ag/5N7
Our new manuscript on by Miyo Ota, Ken Hoehn and collaborators reveals the importance of type2-marked IgG memory cells in food allergy persistence. @SinaiImmunol @hoehnousk @skeinstein biorxiv.org/content/10.110…
B cells in Aranda et al.:In addition to revealing the type2-marked IgG memory B cells, our manuscript has nice scRNAseq analysis of human blood B cells (naïve, memory and plasma from blood of adult atopic and non-atopic subjects. Check it out! @tonestrife @edgarEGK @SinaiImmunol
Aranda et al. shows that 1) type2-marked CD23+IL4R+ IgG memory cells are increased in atopic subjects; 2) their frequency correlates with the level of IgE antibodies; 3) CD23+IL4R+ IgG memory B cells are best among IgG memory cells to switch to IgE onlinelibrary.wiley.com/doi/epdf/10.11…
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